Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma

Burduk, Paweł

doi:10.12659/msm.889011

Cited by 22 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It may serve as an ideal tool in posttreatment surveillance in a patient with laryngeal lesion. Since laryngeal squamous cell carcinoma is one of the most common malignant neoplasms of the head and neck [14] and the prognosis of early malignant disease of the larynx is favorable, it is important for otolaryngologists to have a clear understanding of the clinical features of the premalignant and early malignant changes in the larynx [15]. A majority of malignant neoplasms are of SCC in origin and have almost the same morphology in the upper aerodigestive tract including the head and neck and esophagus.…”

Section: Discussionmentioning

confidence: 99%

Clinical Experiences of NBI Laryngoscope in Diagnosis of Laryngeal Lesions

Qi¹,

Jin²,

Yu³

et al. 2014

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Endoscopy is essential for the diagnosis and treatment of cancers derived from the larynx. However, a laryngoscope with conventional white light (CWL) has technical limitations in detecting small or superficial lesions on the mucosa. Narrow band imaging especially combined with magnifying endoscopy (ME) is useful for the detection of superficial squamous cell carcinoma (SCC) within the oropharynx, hypopharynx, and oral cavity. A total of 3675 patients who have come to the outpatient clinic and complained of inspiratory stridor, dyspnea, phonation problems or foreign body sensation, were enrolled in this study. We describe the glottic conditions of the patients. All 3675 patients underwent laryngoscopy equipped with conventional white light (CWL) and NBI system. 1149 patients received a biopsy process. And 1153 lesions were classified into different groups according to their histopathological results. Among all the 1149 patients, 346 patients (312 males, 34 females; mean age 62.2±10.5 years) were suspected of having a total of 347 precancerous or cancerous (T1 or T2 without lymphnode involvement) lesions of the larynx under the CWL. Thus, we expected to attain a complete vision of what laryngeal lesions look like under the NBI view of a laryngoscope. The aim was to develop a complete description list of each laryngeal conditions (e.g. polyps, papilloma, leukoplakia, etc.), which can serve as a criteria for further laryngoscopic examinations and diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Experiences of NBI Laryngoscope in Diagnosis of Laryngeal Lesions

Qi¹,

Jin²,

Yu³

et al. 2014

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…Its incidence rate is nearly 48,000 cases in the United States and over 500,000 cases worldwide each year [1,2]. The most critical carcinogenic agents for LSCC are cigarette smoke and alcohol while other exogenic and en dogenic factors are mostly promoters or carcinogens in multi plied carcinogenesis processes [3]. The larynx is an important organ required for pronunciation, breathing and swallowing and patients with LSCC have problems with these functions such as dysphonia, dysphagia and dyspnea.…”

mentioning

confidence: 99%

GROα expression and its prognostic implications in laryngeal squamous cell carcinoma

Liang¹,

Liu²,

Chen³

et al. 2015

neo

View full text Add to dashboard Cite

The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known about the association between GROα expression and the clinical attributes of laryngeal squamous cell carcinoma (LSCC).One-step quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and immunohistochemical staining of tissue microarrays were employed to evaluate the relationship between GROα expression and LSCC clinicopathological attributes.GROα mRNA and protein expression levels were significantly greater in LSCC than in non-cancerous tumor-adjacent tissues. GROα protein expression in LSCC was also significantly associated with TNM stage, lymph node metastasis, and histopathological grade. Kaplan-Meier and Cox multi-factor analyses suggested that increased GROα expression and positive lymph node metastasis were significantly associated with the poor survival of LSCC patients.These data indicate that GROα may be a novel prognostic marker of LSCC.

show abstract

“…UreA gene was detected in all cases of LSCC as reported by Burduk et al [34]. They explained their results as all the Polish population is nearly infected with H. pylori, whereas Grbesa et al [3] detected H. pylori ureA gene using PCR in only 26 % of LSCC patients.…”

Section: Discussionmentioning

confidence: 67%

“…It causes in the laryngeal mucosa just like in the gastric mucosa. Thus, it can be correlated with carcinogenesis and tumor progression [4,29,34].…”

Section: Discussionmentioning

confidence: 99%

UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study

Barakat

Nabiel

Ali

et al. 2016

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

This work aims to estimate the prevalence of Helicobacter pylori ureA gene and evaluate cagA gene-positive strains in both patients of laryngeal squamous cell carcinoma (LSCC) and those with benign laryngeal polyps. This study included 49 patients confirmed pathologically to have LSCC and 15 patients with benign laryngeal polyps over a period from June 2013 to March 2015. Samples of laryngeal tissue were collected during direct laryngoscope under general anesthesia to be pathologically evaluated followed by analysis for H. pylori detection. Each laryngeal tissue sample was divided into three parts; one for bacteriological examination, the second for pathological examination and the third for PCR to detect both ureA and cagA genes. Out of 49 LSCC samples, 31 (64.6 %) was positive for ureA by PCR. Out of them, 29 samples (93.5 %) were cagA positive. Only three cases (20 %) of the benign laryngeal polyp were ureA positive by PCR and one of them was cagA positive by PCR. By the bacteriological culture, only eight samples (25.8 %) gave growth. All of them were ureA positive and only seven of them were cagA positive. There was a significant association between presence of H. pylori and LSCC as compared to benign laryngeal polyp which may contribute in the pathogenesis of laryngeal carcinoma. These results should be confirmed by further studies over larger number of cases.

show abstract

Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma

Cited by 22 publications

References 28 publications

Clinical Experiences of NBI Laryngoscope in Diagnosis of Laryngeal Lesions

Clinical Experiences of NBI Laryngoscope in Diagnosis of Laryngeal Lesions

GROα expression and its prognostic implications in laryngeal squamous cell carcinoma

UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study

Contact Info

Product

Resources

About