Association between inflammation and hemostatic markers in atherothrombotic stroke

Regañón, Edelmiro; Vila, Virtudes; Martínez‐Sales, Vicenta; Vayá, Amparo; Lago, Aída; Alonso, Paloma Anguita; Aznar, Justo

doi:10.1016/j.thromres.2003.12.008

Cited by 47 publications

(40 citation statements)

References 16 publications

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“…Approximately 70% of stroke patients have been reported to be over 65 years of age. The mean age of ischemic stroke patients is 60±12.Yoneda et al found this mean age to be 70±1, and Reganonet al as 65.3±8.2 [6,7,8]. In the present study, in harmony with the literature, the mean age was found to be 68.36 ± 16.2.…”

Section: Lacunar Infarct 5 (25)supporting

confidence: 83%

A Retrospective Study on the Acute Ischemic Stroke Patients Followed Up in the Neurology Clinic

Gökçe¹,

Tunçel²,

İnanç³

et al. 2018

Int J Surg Med

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OBJECTIVE: Stroke is one of the most critical diseases causing severe disability and death. The incidence of ischemic stroke increases with advancing age.This study aims to identify the etiologic, epidemiological, demographic and clinical features of acute ischemic stroke patients and to contribute to acute stroke data in our country. MATERIALS AND METHODS: This is a retrospective descriptive study. We reviewed the hospital records of 200 patients who were admitted with acute ischemic stroke between January 2016 and December 2016. RESULTS: Of the patients, 52% were female (n: 104) and mean age of the study group was 68.36±16.2 (23-97). Only 53 patients (26.5%) had applied to the emergency department after four and a half hours after the onset of the symptoms. In medical history of the patients, 62.5% (n:125) had hypertension, 27% (n: 54) had diabetes mellitus, 14.5% (n: 29) had coronary artery disease, and 11% (n: 22) had atrial fibrillation. The mortality rate was found to be 10.5% in patients who were followed up in the neurology clinic. CONCLUSION: Hypertension and diabetes are the most critical risk factors. Patients mostly apply to the emergency departments lately. Although the results of the present study have parallels with those of previous studies, the most crucial problem is the low rate of patients who apply to the emergency department within the first 4.5 hours which is called golden window period.

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Section: Lacunar Infarct 5 (25)supporting

confidence: 83%

A Retrospective Study on the Acute Ischemic Stroke Patients Followed Up in the Neurology Clinic

Gökçe¹,

Tunçel²,

İnanç³

et al. 2018

Int J Surg Med

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“…D-dimer, a marker of activation of the coagulation and fibrinolytic system has gained increasing interest over the recent years. High D-dimer levels have been reported in the acute phase of stroke [4]. Elevated D-dimer level has also been shown to relate to early clinical progression [5], stroke subtypes [6], and infarction volume [7].…”

Section: Introductionmentioning

confidence: 99%

“…Fibrinogen is a thrombotic risk factor which also acts as an acute phase protein. Elevated levels of fibrinogen have been reported after stroke [4] and have been associated with increased risk of recurrent stroke [9].…”

Section: Introductionmentioning

confidence: 99%

The Role of D-Dimer, Fibrinogen and C-Reactive Protein as Plasma Biomarkers in Acute Ischemic Stroke

et al. 2015

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“…1 D-dimer levels are elevated in the acute phase of stroke and subsequently fall. [2][3][4] We previously demonstrated that plasma D-dimer levels (along with mean arterial blood pressure) independently predict progressing ischemic stroke. 5 This measurement of D-dimer was performed with a commercially available ELISA from Biopool AB used in our research laboratory.…”

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confidence: 99%

d -Dimer Predicts Early Clinical Progression in Ischemic Stroke

Barber

Langhorne

Rumley

et al. 2006

Stroke

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Background and Purpose-Plasma D-dimer levels, measured using a research laboratory assay, independently predict progressing ischemic stroke. We wished to confirm these findings using commercially available assays and to provide data to allow the design of intervention studies. Methods-We studied 219 consecutive acute ischemic stroke admissions of whom 54 (25%) met criteria for progressing stroke. Results-There were strong correlations between D-dimer results as measured by the Biopool AB, MDA and VIDAS assays; correlation coefficients rϭ0.91 to 0.94; all PϽ0.001. In binary logistic regression analyses, D-dimer, as measured by the 3 different assays, was an independent predictor of progressing stroke (odds ratios, 1.87 to 2.45; all PϽ0.001). This confirms the results of our original analysis (Biopool AB) using 2 commercial D-dimer assays, demonstrating the potential usefulness of D-dimer in providing early prognostic information after ischemic stroke in different clinical settings. We also provide information on the performance of the 3 assays in predicting progressing stroke at a variety of cutoff values. Conclusions-Ischemic stroke patients at high risk of early progression can be identified using commercial D-dimer measurements. This could allow selection of high-risk patients for inclusion in randomized trials of early antithrombotic treatments. Key Words:arly clinical progression of ischemic stroke is common and is associated with poor prognosis. 1 D-dimer levels are elevated in the acute phase of stroke and subsequently fall. [2][3][4] We previously demonstrated that plasma D-dimer levels (along with mean arterial blood pressure) independently predict progressing ischemic stroke. 5 This measurement of D-dimer was performed with a commercially available ELISA from Biopool AB used in our research laboratory. We wished to confirm our findings using other commercially available assays commonly used by hospital laboratories, particularly the MDA and VIDAS D-dimer assays. Materials and MethodsWe studied consecutive ischemic stroke admissions. 5 Progressing stroke was defined using a modification of the European Progressing Stroke Study definition. 6 This requires deterioration in conscious level, arm or leg weakness, or speech over 72 hours following admission. Blood was taken within 24 hours of symptom onset, and plasma samples were stored at Ϫ80°C before analysis. The MDA D-dimer assay is an automated latex particle-based immunoassay, and the VIDAS D-dimer assay is an automated enzyme-linked fluorescent assay. 7 Univariate analysis of D-dimer levels used unpaired t tests of natural log-transformed levels. Correlations between the different assays were calculated using the Spearman rank method. Multivariate analysis was performed using a stepwise binary logistic regression procedure including variables when significance was found to be PϽ0.10 in univariate analysis. ResultsFifty-four (25%) of the 219 patients recruited met the criteria for progressing stroke. Table 2 shows the sensitivity, specificity, and po...

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Association between inflammation and hemostatic markers in atherothrombotic stroke

Cited by 47 publications

References 16 publications

A Retrospective Study on the Acute Ischemic Stroke Patients Followed Up in the Neurology Clinic

A Retrospective Study on the Acute Ischemic Stroke Patients Followed Up in the Neurology Clinic

The Role of D-Dimer, Fibrinogen and C-Reactive Protein as Plasma Biomarkers in Acute Ischemic Stroke

d -Dimer Predicts Early Clinical Progression in Ischemic Stroke

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