Association between Influenza Vaccination and severe COVID-19 outcomes at a designated COVID-only hospital in Brooklyn

Umasabor‐Bubu, Ogie Queen; Bubu, Omonigho Michael; Mbah, Alfred K.; Nakeshbandi, Mohamed; Taylor, Tonya N.

doi:10.1016/j.ajic.2021.04.006

Cited by 7 publications

(15 citation statements)

References 12 publications

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“…The pooled effect estimates of four studies 12 , 19 , 20 , 28 with a total sample size of 1716 COVID-19 patients indicated no significant difference between influenza vaccinated group and non-vaccinated group in the term of time staying at hospital (MD = − 0.16 , 95% CI [− 2.76, 2.45], P = 0.91; Fig. 3 b).…”

Section: Resultsmentioning

confidence: 97%

“…Fourteen included studies were cohort studies 12 , 13 , 18 – 26 , 28 – 30 , while the remaining two were case-controls 11 , 27 . The included studies had a total sample size of 244,642 patients, of them, 191,496 COVID-19 positive patients.…”

Section: Resultsmentioning

confidence: 99%

“…The included studies had a total sample size of 244,642 patients, of them, 191,496 COVID-19 positive patients. Most of the studies were performed in Italy 13 , 20 , 22 , 23 , 26 , 27 and the USA 12 , 24 , 25 , 28 , 29 , while the others were conducted in Brazil 18 , Poland 19 , Spain 21 , Iran 11 , and England 30 . For SARS-CoV-2 infection identification, all studies used Polymerase Chain Reaction (PCR) test, however, three studies did not report the SARS-CoV-2 infection identification test used 12 , 22 , 29 .…”

Section: Resultsmentioning

confidence: 99%

“…The quality assessment was assessed using the Newcastle–Ottawa scale. Based on the scale, nine 11 , 12 , 19 – 22 , 25 , 26 , 28 out of the sixteen included studies were scored 9/9, and the other seven studies 13 , 18 , 23 , 24 , 27 , 29 , 30 were scored 8/9. All included studies scored a low risk of bias.…”

Section: Resultsmentioning

confidence: 99%

“…Pooled results were heterogeneous ( P < 0.00001, I 2 = 98%). After introducing subgroups according to the countries: USA 12 , 28 , Italian 13 , 20 , 22 , and other countries 19 , 30 , the results remain non-significant in USA and other group (RR = 0.82, 95% CI [0.60, 1.13], P = 0.22), (RR = 0.97, 95% CI [0.86, 1.09], P = 0.58), and also non-significant in the Italian group (RR = 1.87, 95% CI [1.00, 3.49], P = 0.05), (Fig. 2 b).…”

Section: Resultsmentioning

confidence: 99%

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The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis

Almadhoon

Hamdallah

Elsayed

et al. 2022

Sci Rep

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Recent evidence suggests that vaccination against influenza may reduce the clinical outcomes of COVID-19. This study looked at the link between influenza vaccination and the severity of COVID-19 infection. We searched five databases until August 2021. We included studies that reported the relationship between influenza vaccination and COVID-19 outcomes. We pooled the data as risk ratio (RR) or mean difference (MD), with 95% confidence intervals (CIs), the data pooled using fixed and random effects models according to the heterogeneity of results. Sixteen observational studies with 191,496 COVID-19 patients were included. In terms of mechanical ventilation, our analysis showed a significant favor for the influenza vaccinated group over the non-vaccinated group (RR = 0.72, 95% CI [0.54, 0.96], P = 0.03). However, the analysis indicated no statistically significant differences between vaccinated and non-vaccinated groups in the term of mortality rate (RR = 1.20, 95% CI [0.71, 2.04], P = 0.50), hospital admissions (RR = 1.04, 95% CI [0.84, 1.29], P = 0.75), intensive care admissions (RR = 0.84, 95% CI [0.44, 1.62], P = 0.60). There were no significant differences between those who had received the influenza vaccine and those who had not in COVID-19 clinical outcomes, except for mechanical ventilation which showed a significantly lower risk in the influenza vaccinated group compared to the non-vaccinated one. However, future research is encouraged as our data have limitations, and the influenza vaccine is regularly updated. Also, this does not exclude the importance of the influenza vaccine during the COVID-19 pandemic.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis

Almadhoon

Hamdallah

Elsayed

et al. 2022

Sci Rep

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Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis

Pontiroli,

Scovenna,

Carlini

et al. 2024

Journal of Medical Virology

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Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) causes COVID‐19 and has brought a huge burden in terms of human lives. Strict social distance and influenza vaccination have been recommended to avoid co‐infections between influenza viruses and SARS‐CoV‐2. Scattered reports suggested a protective effect of influenza vaccine on COVID‐19 development and severity. We analyzed 51 studies on the capacity of influenza vaccination to affect infection with SARS‐CoV‐2, hospitalization, admission to Intensive Care Units (ICU), and mortality. All subjects taken into consideration did not receive any anti‐SARS‐CoV‐2 vaccine, although their status with respect to previous infections with SARS‐CoV‐2 is not known. Comparison between vaccinated and not‐vaccinated subjects for each of the four endpoints was expressed as odds ratio (OR), with 95% confidence intervals (CIs); all analyses were performed by DerSimonian and Laird model, and Hartung‐Knapp model when studies were less than 10. In a total of 61 029 936 subjects from 33 studies, influenza vaccination reduced frequency of SARS‐CoV‐2 infection [OR plus 95% CI = 0.70 (0.65−0.77)]. The effect was significant in all studies together, in health care workers and in the general population; distance from influenza vaccination and the type of vaccine were also of importance. In 98 174 subjects from 11 studies, frequency of ICU admission was reduced with influenza vaccination [OR (95% CI) = 0.71 (0.54−0.94)]; the effect was significant in all studies together, in pregnant women and in hospitalized subjects. In contrast, in 4 737 328 subjects from 14 studies hospitalization was not modified [OR (95% CI) = 1.05 (0.82−1.35)], and in 4 139 660 subjects from 19 studies, mortality was not modified [OR (95% CI) = 0.76 (0.26−2.20)]. Our study emphasizes the importance of influenza vaccination in the protection against SARS‐CoV‐2 infection.

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Flu vaccine administration in the period before SARS-CoV-2 infection and its outcomes: An umbrella review

Angeletti,

Marchi,

Trombetta

et al. 2024

Preventive Medicine Reports

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Association between Influenza Vaccination and severe COVID-19 outcomes at a designated COVID-only hospital in Brooklyn

Cited by 7 publications

References 12 publications

The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis

The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis

Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis

Flu vaccine administration in the period before SARS-CoV-2 infection and its outcomes: An umbrella review

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