Association between insulin resistance and serum and salivary irisin levels in patients with psoriasis vulgaris

Alataş, Emine Tuğba; Kalaycı, Mehmet; Kara, Ahmet; Doğan, Gürsoy

doi:10.1016/j.dsi.2016.08.004

Cited by 6 publications

(9 citation statements)

References 28 publications

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“…The mean age of patients was 40.89 years (range: 26.03-49.70 years) and that of healthy controls 39.64 years (range: 23.40-49.48 years). Thirteen studies were reported from Turkey [16][17][18][19][20][21][22][23][24][25][26][27][28], eight from Iran [11,[29][30][31][32][33][34][35], seven from India [36][37][38][39][40][41][42], five from Poland [5,[43][44][45][46], three from the USA [47][48][49], two from Spain [2,10], Japan [50,51], Egypt [52,53], and Italy [54,55], one from Austria [56], Romania [1], Portugal [57], Iraq [58], and China [59]. Th...…”

Section: Literature Searchmentioning

confidence: 99%

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

Ramezani¹,

Zavattaro²,

Sadeghi³

2019

pdia

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Introduction: Psoriasis is a T cell-mediated inflammatory skin disease in which fatty acids may be a link between psoriasis and its comorbidity. Aim: The present meta-analysis aimed to evaluate lipid, lipoprotein, and apolipoprotein levels in the psoriatic patients compared with the control subjects. Material and methods: Four databases, including Web of Science, Scopus, PubMed, and Cochrane Library were searched until July 2017. All records analysed were case-control studies. The quality of the questionnaires was evaluated using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was done by Rev Man 5.3 using mean difference (MD) and 95% confidence intervals (CIs). Results: Out of 580 studies identified in four databases, 49 studies were included and analysed in this metaanalysis. The results showed that MD of total cholesterol, triglyceride, LDL, VLDL, HDL, Lp(a), Apo A1, and Apo B levels in the patients compared with the controls were (

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Section: Literature Searchmentioning

confidence: 99%

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

Ramezani¹,

Zavattaro²,

Sadeghi³

2019

pdia

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“…AG-45A-0046YEK-KI01, AdipoGen, Liestal, Switzerland), with a detection limit of 0.001 mcg/mL, intra-assay coefficient of variability (CV) of 6.9% and inter-assay CV of 9.07%. Notwithstanding challenges in the measurement of serum irisin levels [ 15 , 23 ], we adopted a comparable approach with respect to the recent literature [ 26 , 27 , 28 , 29 , 30 ].…”

Section: Methodsmentioning

confidence: 99%

“…Only a few studies have evaluated serum irisin in patients with psoriasis [ 26 , 27 , 28 , 29 , 30 ]. Indeed, the aim of our study was (i) to analyze serum irisin levels in patients with chronic plaque psoriasis, (ii) to compare them with values in control subjects, and (iii) to assess whether the concentration of circulating irisin correlates with the severity of psoriasis calculated by means of Psoriasis Area and Severity Index (PASI).…”

Section: Introductionmentioning

confidence: 99%

Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis

et al. 2022

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Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin levels in patients with chronic plaque psoriasis, to compare them with values in controls, and to assess whether concentration of circulating irisin correlates with the severity of psoriasis, calculated by means of Psoriasis Area and Severity Index (PASI). We enrolled 46 patients with chronic plaque psoriasis; the control group included 46 sex- and age-matched subjects without any skin or systemic diseases. Serum irisin levels were measured by competitive enzyme linked immunosorbent assay. Our results showed a non-significant increase in serum irisin concentration in psoriatic patients compared to controls. A negative non-linear correlation between PASI and irisin levels was detected in psoriatic patients. Indeed, dividing patients according to psoriasis severity, the negative association between irisin and PASI was stronger in patients with mild psoriasis than in patients with higher PASI scores. Several control variables we tested showed no significant impact on serum irisin. However, erythrocyte sedimentation rate in the normal range was associated with significantly higher irisin levels in psoriatic patients. In conclusion, although irisin levels were not significantly different between controls and psoriatic patients, irisin was found to be negatively associated with psoriasis severity, especially in subjects with low PASI scores; however, further studies are needed to clarify the role of irisin in subjects with psoriasis.

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“…Baran et al observed statistically insignificant higher irisin levels in patients with psoriasis compared to a control group [ 11 ]. In another study, patients with severe psoriasis exhibited lower irisin levels than a control group, suggesting that irisin may play a role in the pathogenesis of psoriasis and may be a potential marker showing the severity of psoriasis [ 12 ]. Statistically insignificant high irisin levels have also been detected in hidradenitis suppurativa, another dermatological disease associated with metabolic syndrome and insulin resistance [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

A newly identified myokine: irisin, and its relationship with chronic spontaneous urticaria and inflammation

et al. 2022

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Chronic spontaneous urticaria (CSU) is an important dermatological disease involving severe itchy urticaria lesions and/or angioedema. Urticaria and angioedema occur in the community at a rate of 25–30%. Many factors, such as inflammation, have been implicated in the etiology of CSU. Irisin is a newly identified adipocytokine shown by research to exhibit anti-inflammatory properties in addition to its many other effects. The aim of the study was to investigate, for the first time in the literature, the significance of serum irisin levels in patients with CSU. Seventy-eight individuals were evaluated. The study group included 44 patients diagnosed with CSU, and the control group consisted of 34 healthy individuals. Serum samples were collected, and serum irisin, Interleukin-2 (IL-2), Interleukin-3 (IL-3), Tumor Necrosis Factor-alpha (TNF-α), and Interferon-ɣ (IF-ɣ) levels were determined using the enzyme-linked immunosorbent assay (ELISA) method. Irisin was studied for the first time in patients with CSU and exhibited a significantly higher level in the control group than in the patient group ( p = 0.020). IL-2, IL-3, and IF-ɣ levels were higher in the CSU group than in the control group, although the results were not statistically significant. Only TNF-α results increased significantly. Correlation analysis was applied to determine the relationships between irisin and IF-ɣ and IL-3 levels. This revealed that the irisin parameter was significantly and positively correlated with IF-ɣ and IL-3 in patients with CSU ( r = 0.518, p = 0.016 and r = 0.536, p = 0.022, respectively). This is the first report to evaluate irisin as an inflammatory biomarker in CSU. Irisin levels in patients with CSU were low, suggesting that irisin may pay a role in the pathogenesis of CSU and may be a marker showing the severity of the disease.

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Association between insulin resistance and serum and salivary irisin levels in patients with psoriasis vulgaris

Cited by 6 publications

References 28 publications

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies

Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis

A newly identified myokine: irisin, and its relationship with chronic spontaneous urticaria and inflammation

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