Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital

Singh, Bhawna; Goswami, Binita; Mallika, V.

doi:10.1007/s12291-010-0026-x

Cited by 56 publications

(49 citation statements)

References 22 publications

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“…Such difference was previously stated by studies that claim that hypothyroidism is related to impairments of glucose and insulin metabolism specially insulin resistance (IR) and subsequent altered peripheral glucose disposal [5-7, 21, 42, 43]. However, many studies relate overt hypothyroidism to IR [20,43,6], but it has less been paid attention in case of subclinical hypothyroidism. The effect of hormone replacement therapy on glucose and insulin metabolism of hypothyroid patients was formerly investigated, but not in the case of sHT; [4] found a high prevalence of IR in hypothyroid patients in comparison to euthyroid controls.…”

Section: Discussionmentioning

confidence: 98%

“…The concomitant hypothyroidism and insulin resistance can cause reduction of peripheral and even myocardial blood flow which can finally define the pathogenic effects of insulin resistance [5][6][7]. 46% of the case groups were obese according to BMI > 25 kg/m 2 .…”

Section: Discussionmentioning

confidence: 99%

“…This condition mostly affects women and is an agedependent disorder [2] resulting in several health complications including: impaired glucose and insulin metabolism [3], dyslipidemia, and cardiovascular disorders [4]. Insulin resistance and altered peripheral glucose disposal are the main reverse effects of sHT on carbohydrate metabolism [5], so that insulin resistance leads to increase in hepatic cholesterol production and also very low density lipoprotein (VLDL) against elevated clearance of high density lipoprotein (HDL) [6]. Hence high levels of TSH and consequent insulin resistance are the underlying risk factors of dyslipidemia in such patients [7].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore it is not surprising that alterations in TH levels may change lipid metabolism. The main manifestations of sHT on lipid profile include elevated levels of total cholesterol (TC), triglyceride (TG), and particularly low density lipoprotein (LDL) [10,11], and decrease in high density lipoprotein (HDL) [6,12]. There are studies reporting the normalization of LDL levels in hypothyroid patients after hormones replacement therapy [13].…”

Section: Introductionmentioning

confidence: 99%

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Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Hashemi

Kosari

Mansourian

et al. 2017

Romanian Journal of Internal Medicine

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Background. Subclinical hypothyroidism (sHT) is a condition defined by elevated TSH values with normal levels of free thyroid hormones. Altered metabolic status is one of the consequences of sHT which can affect serum levels of FPG, lipid profile, and nitric oxide which propounds cardiovascular consequences per se. The aim of this study was to determine the possible effects of sHT on nitrite/nitrate levels, as a marker of endothelial performance.Materials and Methods. 50 females were enrolled in this study, 25 women as control group and 25 women as case group (evaluated two times: before and after levothyroxine therapy). Blood samples were collected and levels of FPG, lipid profile components, and nitric oxide were measured spectrophotometrically. The data were analyzed using SPSS version 18 software.Results. The levels of lipid profile (except for TG between before and after group, p < 0.05) and nitric oxide did not differ in groups while FPG was significantly higher in case groups in comparison to control group (p < 0.001). Nitric oxide had no correlations with any of variables except for LDL in after treatment group (p < 0.05 and r = 0.397).Conclusion. Nitric oxide does not have correlation with components of lipid profile (except for LDL) or FPG and has no differences in subclinical hypothyroid patients and control group. Levothyroxine therapy during 2 months cannot alter the levels of nitric oxide in subclinical hypothyroid patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Hashemi

Kosari

Mansourian

et al. 2017

Romanian Journal of Internal Medicine

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“…Insulin resistance is a cardinal feature of type 2 diabetes mellitus and increased risk of dyslipidemia along with relatively frequently found mild thyroid dysfunction [15]. B M Singh et al study illustrates the complex interplay between thyroid hormonal status and insulin levels in the pathogenesis of insulin resistance [16].…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and thyroid hypofunction in obese women – A cross sectional study

Farishta¹,

Farishta²

2015

Integr Obesity Diabetes

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We evaluated the relationship between thyroid hypofunction and insulin resistance among obese female patients visiting to endocrinology outpatient clinics (OPD) done at Sparsh Endocrinology & Diabetic Center. In this cross-sectional study, a total of fifty female subjects with age group of 30-60 years, whose body mass index was above 30 kg/m2 were studied for 16 months between July 2013 to November 2014 who were attending our endocrinology OPD were studied. Subjects with known disease or disorder of endocrine systems or who were receiving medications like, thyroid hormones preparations, Lithium, Amiodarone or corticosteroids were excluded. Blood samples were assed for T3, T4, TSH, FBS, Fasting Insulin and HOMA IR was calculated. A total of fifty subjects participated in the study. The mean age of the patients was 31.4 ± 7.32 years. Among these subjects TSH analysis revealed that 26% were having subclinical hypothyroidism (SCH). We found that 46% of these SCH subjects are having insulin resistance while 24% of patients with normal thyroid function are having insulin resistance as estimated by HOMA IR. P-value=0.6 and the odds ratio is 0.667, with a 95% confidence interval extending from 0.19 to 2.09. The observed difference in insulin resistance was not statistically between the subjects with SCH and normal obese subjects. In our study we observed that insulin resistance co exists with thyroid-hypo function in 46% of obese subjects. Caution has to be executed in interpretation of results as our sample is small.

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Meta‐analysis of the association between maternal subclinical hypothyroidism and gestational diabetes mellitus

Jia

Lin

et al. 2019

Intl J Gynecology & Obste

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Background Subclinical hypothyroidism (SCH) and gestational diabetes mellitus (GDM) are common endocrine disorders that occur during pregnancy. Objective To determine whether the risk of GDM differs between pregnant women with normal thyroid function and those with SCH. Search strategy MEDLINE, EMBASE, the Cochrane Library, and Web of Science were searched for studies published in English from inception to March 1, 2017, using combinations of the search terms “thyroid dysfunction”, “thyroid diseases”, “subclinical hypothyroidism”, “hypothyroxinemia”, “thyrotropin”, “gestational diabetes”, “hyperglycemia in pregnancy”, and “adverse pregnancy outcomes”. Selection criteria We selected cohort studies that included pregnant women with SCH; in which the outcome of interest was, or included, the incidence of GDM; and that had data available for both the SCH and GDM groups. Studies were excluded if assisted reproductive technologies were used to achieve pregnancy; reviews, abstracts, and case reports were also excluded. Data collection and analysis Eleven studies were included in the analysis. Summary odds ratios (ORs) for the risk of GDM were calculated. Main results SCH with positive antithyroid autoantibodies markedly increased GDM risk (OR 3.22, 95% confidence interval 1.72–6.03, I2=55%). Conclusion SCH with positive antithyroid autoantibodies in pregnancy is associated with an increased risk of GDM.

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Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital

Cited by 56 publications

References 22 publications

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Insulin resistance and thyroid hypofunction in obese women – A cross sectional study

Meta‐analysis of the association between maternal subclinical hypothyroidism and gestational diabetes mellitus

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