Association Between Interleukin‐1 Genotype and Periodontal Disease in a Diabetic Population

Abstract

These data confirm the high prevalence and severity of periodontitis in the diabetic population, and support the association between poor glycemic control and periodontal disease. The low prevalence of some of the IL-1 gene polymorphisms in the ethnic groups included in this study limits the validity of conclusions on genotype associations with clinical findings, but there was a trend suggesting that allele 1 at IL-1B (-511) and IL-1B (+3954) was overrepresented among diabetics with periodontal disease.

Chronic Periodontitis as a Risk Marker for Systemic Diseases with Reference to Cardiometabolic Disorders: Common Pathways in their Progression

“…81 Evidence of a direct association between DM and periodontitis has been reviewed in the literature. 82 Significant correlations between periodontal disease parameters and poor glycaemic control have been demonstrated 83,84 and other reports of a reciprocal relationship between periodontal disease and glycaemic control. 85,86 Cross sectional studies on Pima Indians representing uncontrolled disease displayed the highest global prevalence of type 2 DM demonstrating an odds ratio of 2.8 to 3.4 for developing periodontal disease in type 2 DM compared with non-diabetic controls.…”

Epidemiology and Risk Factors of Periodontal Disease

“…Periodontal parameters examined have included gingivitis, clinical attachment loss, and alveolar bone loss (Tomar & Asma, 2000). Studies have shown a relationship between poor glycemic control and periodontal disease parameters (Cutler et al, 1999;Guzman et al, 2003;Tervonen et al, 1994;Tsai et al, 2002). Finally, studies have been done which suggest that poorly controlled diabetics respond less successfully to periodontal therapy relative to well-controlled and non-diabetics (Westfelt et al, 1996;Tervonan & Karjalainen, 1997).…”

The Role of Genetic Predisposition in Diagnosis and Therapy of Periodontal Diseases in Type 1 Diabetes Mellitus

“…Periodontitis involves multiple clinical patterns including various severities of periodontitis, uncommon early onset forms that affect children and young adults with type 1 DM, and patients who do not respond predictably to conventional therapy refractory periodontitis. Guzman et al 71 have shown a possible interactions between genetic an enviromental factors that there is interplay between genetic an environmental factors that results in periodontal disease. The finding that a specific genotype in the IL-1 gene cluster correlates with severe periodontitis suggest a genetic mechanism by which some individuals, if challenged by bacterial accumulations, may have a more vigorous immuno-inflammatory response leading to more severe periodontitis in type 1 DM.…”