Association between interleukin‐19 and angiopoietin‐2 with vascular complications in type 2 diabetes

Li, Li; Yu, Zhiping; Juan-Yu, Hu; Xu, Jing; Liu, Fan; Zhao, Guisen; Zhang, Lei; Gu, Huijie; Zhang, Si-Jing; Jin, Meng

doi:10.1111/jdi.12519

Cited by 15 publications

(13 citation statements)

References 34 publications

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“… 10 , 11 IL-19 can be detected in human monocytes, 12 and the expression of IL-19 can be enhanced by stimulating B and T lymphocytes. 13 Studies show that increased IL-19 is involved in the incidence of autoimmune diseases 12 such as psoriasis, asthma, and rheumatoid arthritis by upregulating pro-inflammatory cytokines. 14 Monocytes treated by IL-19 induce the production of IL-6, tumor necrosis factor-α (TNF-α), and reactive oxygen metabolites, which play a pro-inflammatory role in the development of COPD.…”

Section: Introductionmentioning

confidence: 99%

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

Biaoxue¹,

Liu²,

Li³

et al. 2018

COPD

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BackgroundThe aim of this study was to disclose the correlation between the serum levels of hypoxia-inducible factor 1 alpha (HIF-1α) and IL-19 and stable COPD.MethodsThe serum levels of HIF-1α and IL-19 were tested by ELISA. The relationships between their levels and clinical parameters of stable COPD patients were analyzed by linear regression methods.ResultsPatients with stable COPD showed higher serum levels of HIF-1α and IL-19 compared with healthy control group (P<0.001), and serum levels of HIF-1α and IL-19 had a positive linear correlation (P<0.05). In stable COPD patients, increased serum levels of HIF-1α and IL-19 were positively correlated with the GOLD grading (P<0.005), modified British Medical Research Council (mMRC) score (P<0.05), and medical history (P<0.05) but negatively related to the pulmonary function (P<0.05). The serum level of HIF-1α (P<0.05) was affected by the patient’s FEV1/FVC value and COPD grading, and the serum level of IL-19 was associated with the mMRC scores and the serum level of HIF-1α (P<0.05).ConclusionIncreased serum levels of HIF-1α and IL-19 correlated with the disease progression of COPD, suggesting that they can be used as indicators to help us understand the COPD.

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Section: Introductionmentioning

confidence: 99%

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

Biaoxue¹,

Liu²,

Li³

et al. 2018

COPD

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“…Several recent studies have revealed that the roles of IL-19 in development of vascular inflammatory diseases such as atherosclerosis, restenosis, and coronary artery transplant vasculopathy. Our previous also reported that IL-19 is closely related to T2DM with vascular complications [ 21 ]. However, whether there are some association between IL-19 concentration and DN have not been revealed clearly yet.…”

Section: Introductionmentioning

confidence: 99%

The association between interleukin-19 concentration and diabetic nephropathy

Li¹,

Juan-Yu

et al. 2017

BMC Nephrol

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BackgroundInterleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10(IL-10) family. IL-19 have indispensable functions in many inflammatory processes and also can induce the angiogenic potential of endothelial cells. The purpose of present study was to investigate the relation of serum interleukin-19 (IL-19) levels with diabetic nephropathy (DN).MethodsTwo hundred study groups of patients with type 2 diabetes mellitus (T2DM) (109 males and 91 females) were recruited, included normoalbuminuria(n = 102), microalbuminuria(n = 72) and macroalbuminuria(n = 26) . The 50 healthy blood donors were enrolled for the control group. All subjects were assessed for: IL-19, High-sensitivity C-reactive protein (Hs-CRP), Cystatin C, urinary albumin excretion rate (UAE) and glycosylated hemoglobin A1c(HbA1c).ResultsThe serum IL-19 levels in DN patients were found to be significantly higher compared to controls. IL-19 levels were significantly positively correlated with Hs-CRP, Cystatin C, UAE and HbA1c(r = 0.623, 0.611,0.591 and 0.526 respectively, P < 0.01). Multivariable logistic regression analysis showed IL-19 levels (P = 0.01) were found to be independently associated with patients with DN.ConclusionsIL-19 is significantly positive correlated with UAE and Cystatin C. IL-19 may play an important role that contributes to the progression of diabetic nephropathy.

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“…A recent study showed that serum Ang2 levels in T2DM patients with angiopathy were significantly higher than in patients without angiopathy and were correlated with HOMA-IR and HbA1c [69]. A positive correlation was also recently found between levels of Ang2 and IL-19, a cytokine associated with a number of concurrent microvascular and macrovascular lesions [70,71]. In diabetic nephropathy, Ang2 is also correlated with IL-18, and in high glucose conditions, Ang2 induced IL-18 expression.…”

Section: Ang1 and Ang2 In Diabetic Vascular Complicationsmentioning

confidence: 89%

Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes

Isidori

Venneri

Fiore

2016

J Endocrinol Invest

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The morbidity and mortality of diabetes mellitus are mostly attributed to cardiovascular complications. Despite tremendous advancement in glycemic control, anti-diabetic medications have failed to revert vascular impairment once triggered by the metabolic disorder. The angiogenic growth factors, Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2), are crucial regulators of vessel formation and maintenance starting with embryonic development and continuing through life. In mature vessels, angiopoietins control vascular permeability, inflammation and remodeling. A crucial role of angiopoietins is to drive vascular inflammation from the active to the quiescent state, enabling restoration of tissue homeostasis. The mechanism is of particular importance for healing and repair after damage, two conditions typically impaired in metabolic disorders. There is an emerging body of evidences suggesting that the imbalance of Ang1 and Ang2 regulation, leading to an increased Ang2/Ang1 ratio, represents a culprit of the vascular alterations of patients with type-2 diabetes mellitus. Pharmacological modulation of Ang1 or Ang2 actions may help prevent or delay the onset of diabetic vascular complications by restoring vessel function, favoring tissue repair and maintaining endothelial quiescence. In this review, we present a summary of the role of Ang1 and Ang2, their involvement in diabetic complications, and novel therapeutic strategies targeting angiopoietins to ameliorate vascular health in metabolic disorders.

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Association between interleukin‐19 and angiopoietin‐2 with vascular complications in type 2 diabetes

Cited by 15 publications

References 34 publications

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

The association between interleukin-19 concentration and diabetic nephropathy

Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes

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Association between interleukin‐19 and angiopoietin‐2 with vascular complications in type 2 diabetes

Cited by 15 publications

References 34 publications

Correlation of serum levels of HIF-1&alpha; and IL-19 with the disease progression of COPD: a retrospective study

Correlation of serum levels of HIF-1&alpha; and IL-19 with the disease progression of COPD: a retrospective study

The association between interleukin-19 concentration and diabetic nephropathy

Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes

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Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study

Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study