Association between interleukin-8 gene −251 A/T polymorphism and the risk of coronary artery disease

Abstract

Background: The association between interleukin-8 (IL-8) gene polymorphism −251 A>T and susceptibility to coronary artery disease (CAD) has been investigated previously; however, results remain controversial. Thus, a meta-analysis was conducted to reassess the effects of this polymorphism on CAD risks. Methods: The PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies published up to December, 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for allelic (A vs T) as well as homozygote (AA vs TT), heterozygote (AT vs TT), recessive (AA vs AT + TT), and dominant (AA + AT vs TT) genotype models, respectively. Results: Ten case-control studies (3744 cases and 3660 controls) were included. Overall, a significant association of IL-8 gene −251 A > T polymorphism with an increased risk of CAD was only observed in the dominant genotype model (OR = 1.48), but not others. In the subgroup analysis, significantly increased risks were also found for Chinese (OR = 1.64), polymerase chain reaction-restriction fragment length polymorphism genotyping (OR = 1.61), acute coronary syndrome (ACS) type (OR = 1.92 for 3 datasets; OR = 1.88 for 4 datasets), high quality (OR = 1.64), and age/gender matching status (OR = 1.55) under the dominant model. Furthermore, significantly increased risks were also found for ACS type under allelic (OR = 1.32 for 3 datasets; OR = 127 for 4 datasets), homozygote (OR = 1.64 for 3 datasets; OR = 1.50 for 4 datasets), heterozygote (OR = 1.32 for 3 datasets; OR = 1.30 for 4 datasets), and recessive (OR = 1.40 for 3 datasets; OR = 1.28 for 4 datasets) models. Conclusion: This meta-analysis suggests that Chinese patients carrying −251A allele of IL-8 may have an increased risk for the development of CAD, especially ACS.

Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications

“…In this context, increased TLR2 on epithelial cells stimulates the secretion of the cytokines such as IL-6 and IL-8. A connection between high levels of IL-6 and cardiovascular disease ( Qu et al, 2014 ), as well as an association between IL-8 and high risk of coronary artery disease ( Zhang et al, 2019a , b ) have also been reported.…”

Variación en un solo nucleótido en genes de citocinas como marcadores de enfermedades

“…IL- Babusikova y col 23 You y col 24 Popko y col 26 Fang y col 27 Moleres y col 28 Wu y col 29 Hu y col 30 Avendaño y col 31 Ulhaq y col 32 −572 G/C Artritis reumatoide Glaucoma primario de ángulo abierto You y col 24 Wu y col 29 -1363 T/G Glaucoma primario de ángulo abierto Wu y col 29 IL-8 -251 A/T Cáncer Cáncer de mama en mujeres iraníes Enfermedad coronaria arteriosclerótica Periodontitis Infección por Clostridium difficile Liua y col 34 Kamali-Sarvestani y col 35 Zhang y col 37 Yang y col 38 Garey y col 39 +781 C/T Carcinoma hepatocelular en población taiwanesa Púrpura de Henoch-Schönlein Osteoartritis Asma bronquial Enfermedad de graves Degeneración macular…”

“…En el metaanálisis desarrollado por Zhang y colaboradores se evaluaron los efectos del SNV -251A/T y el riesgo de sufrir una enfermedad coronaria arteriosclerótica en habitantes de China y se encontró que las personas portadoras del alelo -251A pueden tener un mayor riesgo de desarrollar la enfermedad. 34 En el mismo metaanálisis también se encontró asociación positiva del SNV-251T/A con la periodontitis 35 y con la predisposición a la infección por Clostridium difficile. 36 Variaciones en el gen de la IL-8 se han relacionado además con el desarrollo de enfermedades autoinmunes y degenerativas.…”

Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population

“…The CAD has been confirmed through the epidemiological studies as multigene cum multifactorial regulated human disease ( Fan et al, 2020 ). The estimated mortality rate will be about 23 million by 2030 ( Zhang et al, 2019 ). Nine million deaths have been recorded in all ages of subjects with CAD and known to be the one of the cause of mortality global-wide ( Zheng et al, 2020 ).…”