Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Zhu, Yongjian; Liu, Xiaozhuan; Li, Ning; Cui, Lingling; Zhang, Xiaofeng; Liu, Xinxin; Yu, Kai-Lun; Chen, Yao; Wan, Zhongxiao; Yu, Zengli

doi:10.3389/fmed.2019.00303

Cited by 11 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, sTfR was elevated in chronic hypoxic diseases such as cystic fibrosis in a clinical study 8 . Second, there is a relationship between TfR and chronic diseases such as DM 9 , CKD 10 , heart failure 11 , and cancer 30 , 31 . In our study, high sTfR was associated with CKD.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have demonstrated a significant association between sTfR and chronic disease 9 , 10 . One longitudinal study showed that higher sTfR was associated with the risk of diabetes mellitus (DM) among overweight and obese participants 9 .…”

Section: Introductionmentioning

confidence: 99%

“…One longitudinal study showed that higher sTfR was associated with the risk of diabetes mellitus (DM) among overweight and obese participants 9 . In another cross-sectional study, it was shown that sTfR and the prevalence of chronic kidney disease (CKD) were correlated 10 . Moreover, studies on sTfR and mortality were mainly conducted in high-risk patients with cardiovascular disease 11 – 15 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Soluble transferrin receptor can predict all-cause mortality regardless of anaemia and iron storage status

Kang

Kwon

Lee

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Despite interest in the clinical implications of soluble transferrin receptor (sTfR), previous studies on the association of sTfR with mortality in the general population are lacking. Therefore, we analysed the association between sTfR and all-cause mortality in the general United States adult population. We conducted a prospective cohort study using National Health and Nutrition Examination Survey data from 2003 to 2010. A total of 5403 premenopausal nonpregnant females were analysed in this study. The mean age was 34.2 years (range 20.0–49.9 years). Participants were divided into log(sTfR) tertiles. The primary outcome was all-cause mortality. The secondary outcome was chronic kidney disease (CKD) development (composite of estimated glomerular filtration rate < 60 ml/min/1.73 m2 and/or random urine albumin-to-creatinine ratio ≥ 30 mg/g). During a median 8.7 years of follow-up, 103 (1.9%) participants died. Compared with the reference group (log(sTfR) 0.45–0.57), the highest tertile of log(sTfR) was associated with all-cause mortality (log(sTfR) > 0.57, hazard ratio [HR] 1.77 [95% CI 1.05–2.98]) in a multivariable hazards model including covariates such as haemoglobin and ferritin. Patients in the highest tertile of log(sTfR) also had an increased risk of CKD relative to those in the reference tertile. High sTfR was associated with all-cause mortality and CKD regardless of anaemia and iron storage status.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Soluble transferrin receptor can predict all-cause mortality regardless of anaemia and iron storage status

Kang

Kwon

Lee

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Our results showed that the highest iron intake levels (<7 mg/day; ≥13.3 mg/day) were associated with an increased risk of CKD stage 3B and over compared with the intake at recommended levels (7–10 mg/day). CKD patients are recommended to consume adequate levels of iron to prevent anemia [ 21 ]. For the general population, there were few studies on the association between dietary iron intake and risk of CKD in prospective cohort study.…”

Section: Discussionmentioning

confidence: 99%

Dietary Micronutrients and Risk of Chronic Kidney Disease: A Cohort Study with 12 Year Follow-Up

Lee

Park

2021

Nutrients

View full text Add to dashboard Cite

We investigated the association between dietary micronutrient intakes and the risk of chronic kidney disease (CKD) in the Ansan-Ansung study of the Korean Genome and Epidemiologic Study (KoGES), a population-based prospective cohort study. Of 9079 cohort participants with a baseline estimate glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and a urine albumin to creatinine ratio (UACR) <300 mg/g and who were not diagnosed with CKD, we ascertained 1392 new CKD cases over 12 year follow-up periods. The risk of CKD according to dietary micronutrient intakes was presented using hazard ratios (HRs) and 95% confidence intervals (95% CIs) in a full multivariable Cox proportional hazard models, adjusted for multiple micronutrients and important clinico-epidemiological risk factors. Low dietary intakes of phosphorus (<400 mg/day), vitamin B2 (<0.7 mg/day) and high dietary intake of vitamin B6 (≥1.6 mg/day) and C (≥100 mg/day) were associated with an increased risk of CKD stage 3B and over, compared with the intake at recommended levels (HR = 6.78 [95%CI = 2.18–21.11]; HR = 2.90 [95%CI = 1.01–8.33]; HR = 2.71 [95%CI = 1.26–5.81]; HR = 1.83 [95%CI = 1.00–3.33], respectively). In the restricted population, excluding new CKD cases defined within 2 years, an additional association with low folate levels (<100 µg/day) in higher risk of CKD stage 3B and over was observed (HR = 6.72 [95%CI = 1.40–32.16]). None of the micronutrients showed a significant association with the risk of developing CKD stage 3A. Adequate intake of micronutrients may lower the risk of CKD stage 3B and over, suggesting that dietary guidelines are needed in the general population to prevent CKD.

show abstract

“…The factors consistently associated with ferritin levels both pretherapy in CHC patients and at 24 weeks posttherapy in SVR patients, such as ALT, TG, eGFR, and Fe/TIBC, exhibited fundamental links with ferritin, regardless of HCV infection. For example, ferritin levels > 1.5 times higher than normal are usually seen in patients with a > 6 month history of elevated ALT 25 , high TG levels are strongly associated with ferritin levels 26 , every 100 μg/L increase in 27 , and the positive association between ferritin levels and transferrin saturation (Fe/TIBC) reflects the correlation between iron store and iron availability 28 . In contrast, the pretherapy-only factors (sex, HOMA-IR, hemoglobulin and IFNL3-rs12979860 genotype) and posttherapy-only factors (TC and anti-HCV therapy) suggested potential links, direct or indirect, between HCV infection and ferritin levels.…”

Section: Discussionmentioning

confidence: 99%

Evolution of ferritin levels in hepatitis C patients treated with antivirals

Chang

Yen

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The evolution of ferritin levels in hepatitis C virus (HCV)-infected patients with sustained virological responses (SVRs) following various therapy regimens remains elusive. An 8-year prospective cohort study of 1194 HCV-infected patients [interferon-based therapy (n = 620), direct-acting antiviral agent (DAA) therapy (n = 355)] was conducted. At baseline, sex, alanine aminotransferase (ALT), triglycerides, homeostatic model assessment of insulin resistance (HOMA-IR), estimated glomerular filtration rate (eGFR), hemoglobin, iron/total iron-binding capacity (Fe/TIBC) and IFNL3-rs12979860 genotypes were associated with ferritin levels. At 24 weeks posttherapy, ALT, triglycerides, total cholesterol, eGFR, Fe/TIBC and the therapy regimen were associated with ferritin levels in SVR patients. Among interferon-treated patients, ferritin levels increased at 24 weeks posttherapy, regardless of SVR, and 24-week posttherapy ferritin levels were higher in non-SVR patients (n = 111) than in SVR patients (n = 509); ferritin levels began decreasing at 3 years posttherapy and were lower than pretherapy levels since 4 years posttherapy in SVR patients. Among DAA-treated SVR patients (n = 350), ferritin levels decreased and remained stable since 24 weeks posttherapy. ALT, triglycerides, eGFR, and Fe/TIBC were HCV-unrelated factors associated with ferritin levels; sex, HOMA-IR, total cholesterol, hemoglobin and IFNL3-rs12979860 genotype were HCV-related factors associated with ferritin levels. In interferon-treated SVR patients, the increased trend of posttherapy ferritin levels was not reversed until 4 years posttherapy. In DAA-treated SVR patients, ferritin levels decreased since 24 weeks posttherapy.

show abstract

Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults

Cited by 11 publications

References 37 publications

Soluble transferrin receptor can predict all-cause mortality regardless of anaemia and iron storage status

Soluble transferrin receptor can predict all-cause mortality regardless of anaemia and iron storage status

Dietary Micronutrients and Risk of Chronic Kidney Disease: A Cohort Study with 12 Year Follow-Up

Evolution of ferritin levels in hepatitis C patients treated with antivirals

Contact Info

Product

Resources

About