Association between irritable bowel syndrome and asthma: a meta-analysis and systematic review

Deshmukh, Farah; Vasudevan, Anupama; Mengalie, Erika

doi:10.20524/aog.2019.0426

Cited by 12 publications

(16 citation statements)

References 29 publications

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“…Furthermore, asthma patients have increased enteric permeability compared to healthy persons, making them more prone to IBS symptoms. 17 In our study, no significant difference in asthma was found between the IBS and non-IBS groups, even though the odds ratio was quite high at 3.1 in patients with a history of asthma. This result was similar to a meta-analysis that reported a pooled IBS odds ratio in adults to be 2 (95%CI 1.5 to 2.8).…”

Section: Discussioncontrasting

confidence: 66%

Prevalence and risk factors of irritable bowel syndrome in adolescents

Kadim

Tantri

Ramadani

2021

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Background Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in children and adults. The IBS is diagnosed by symptoms that fulfill the Rome IV criteria. This condition can impact quality of life, especially in adolescents. Objectives To investigate the prevalence of IBS in high school students and analyze its risk factors. Methods This cross-sectional study was done with e-questionnaires from Rome IV Diagnostic Questionnaire on Pediatric Functional Gastrointestinal Disorders (R4PDQ). Students from high school and occupational schools age 14 to 18-years-old in Jakarta were included in this study. Possible risk factors for IBS were analyzed using Fisher’s exact test for bivariate analysis and logistic regression for multivariate analysis. Results Of 210 subjects, 10 (4.8%) had IBS. The IBS-M and IBS-C subtypes were more common than IBS-D. Gastrointestinal infection history was significantly associated with IBS (OR 7.1; 95%CI 1.7 to 29.3; P=0.013). Other factors such as gender, corporal punishment, asthma, spicy and fatty food consumption, as well as socioeconomic status were not significantly associated with IBS (P>0.05). Conclusion The prevalence of IBS in adolescents is 4.8%. History of gastrointestinal infection is a risk factor for IBS.

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Section: Discussioncontrasting

confidence: 66%

Prevalence and risk factors of irritable bowel syndrome in adolescents

Kadim

Tantri

Ramadani

2021

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“…Generally, depression and anxiety are highly associated with medical conditions such as hypertension (Ginty et al, 2013). A recent publication on systematic review suggested a strong association between IBS and asthma was probably explained by immune system activation and increased intestinal permeability, a link between hyperresponsiveness in atopy and enteric nervous system (Deshmukh et al, 2019). The exact mechanism was not fully understood on how one condition such as IBS leads to another condition such as asthma, or vice versa.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Subthreshold Depression Among Constipation-Predominant Irritable Bowel Syndrome Patients

et al. 2020

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Patients suffering from irritable bowel syndrome (IBS) may have some form of affective disorders that may worsen their symptoms. Lack of screening among IBS patients is one of the reasons for depression unawareness among healthcare providers. The present study was conducted to evaluate the prevalence of depression among patients with constipation-predominant IBS (IBS-C). A total of 240 IBS patients who fulfilled Rome III criteria were enrolled. The psychiatric assessment was evaluated using the Center for Epidemiologic Studies Depression Scale Revised (CESD-R). Twenty items in CESD-R scale measured symptoms of depression in nine separate groups. Patients were categorized into five different subgroups: major depressive episode, probable major depressive episode, possible major depressive episode, subthreshold depressive symptoms, and without clinical significance of depression. Out of the 240 patients with IBS-C, the majority (n = 161, 67.1%) had no clinical significance of depression. Seventy seven (32.1%) had subthreshold depression and only two (0.83%) patients were regarded as having probable a major depressive episode. No patient was categorized into a major or possible major depressive episode. The prevalence of subthreshold depression was the highest among female (72.3%) patients with 51.1% being single, 44.7% were married, and 4.3% were divorcees. When stratified according to ethnicity, subthreshold depression was highly prevalent among Malays (76.6%), followed by Chinese (19.2%), and Indians (2.1%). A high percentage of the patients were found to be non-smokers (93.6%) and had lower income of less than RM 5000 (USD 1250) per month (89.4%). The moderately high prevalence of subthreshold depression among patients with IBS, justifies psychological evaluation in all patients with functional gastrointestinal disorders.

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“…Yilmaz et al reported an odds ratio of 2.65 (95% CI, 1.25-5.57), meanwhile, Ozol et al reported an odds ratio of 3.21 (95% CI, 1.53-6.70) in their study [ 5 , 6 ]. A meta-analysis showed a I 2 value of 0% (P=0.8) and an OR of 2.6 (95%CI 1.9-3.5) [ 13 ]. In a study by Kennedy et al, they found that IBS, GERD, and symptomatic bronchial hyper-reactivity occur more frequently together than expected, and these conditions are independently associated with each other [ 14 ].…”

Section: Discussionmentioning

confidence: 99%