Association between killer cell immunoglobulin-like receptor (KIR) polymorphisms and systemic lupus erythematosus (SLE) in populations

Abstract

Background:Recently, a growing number of studies show that the killer cell immunoglobulin-like receptor (KIR) gene polymorphisms may play a role in the systemic lupus erythematosus (SLE) susceptibility. Nonetheless, the results were inconsistent. Thus, a meta-analysis was carried out by integrating multiple research to clarify the association between KIR polymorphisms and SLE susceptibility.Methods:The Web of Science, Embase (Ovid), PubMed, Elsevier Science Direct, the Chinese Biomedical Database and CNKI, Wanfang databases (last search was updated on May 15, 2016) were systematically searched to select studies on addressing the association between the KIR polymorphisms and susceptibility to SLE in populations. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated.Results:A total of 10 published case-control studies involving 1450 SLE patients and 1758 controls were available for this meta-analysis. Results suggested that KIR2DL1 might be a risk factor for SLE (OR 2DL1 =1.047, 95% CI=1.011–1.083) in all subjects. The KIR2DL3, KIR2DL5 were identified as protective factors for SLE in Asian populations (OR2DL3= 0.215, 95% CI = 0.077–0.598; OR2DL5 = 0.588, 95% CI = 0.393–0.881), but not in Caucasians.Conclusions:The meta-analysis results suggested that 2DL1 might be a potential risk factor and 2DL3, 2DL5 might be protective factors for SLE in Asians but not in Caucasians.

Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility

“…The previous meta-analysis has been conducted in the association of KIR gene and susceptibility to rheumatoid arthritis and systemic lupus erythematosus. [38,39] To comprehensively analyze these associations between KIR gene polymorphisms and patients with T1DM in different ethnic groups, a meta-analysis was performed.…”

Effects of the killer immunoglobulin–like receptor (KIR) polymorphisms on HIV acquisition: A meta-analysis

“…To our knowledge, this is the first meta-analysis that examines KIR effects on HIV acquisition. By extension, associations of the KIR polymorphisms have been reported in a number of meta-analyses that included disease endpoints such as systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus and multiple sclerosis [54–57]. The only other meta-analysis for KIR polymorphisms with another infectious disease is that of Gauthiez et al’s examination of the Hepatitis C Virus (HCV) infection with HCV clearance [58].…”

Association of KIR gene polymorphisms with Type 1 Diabetes: a meta-analysis

“…Among them, six KIRs, including KIR2DS1-5, and 3DS1, which have a short cytoplasmic tail, are considered as activating KIRs. Nine KIRs, including KIR2DL1-4, 2DL5A, 2DL5B, and 3DL1-3, are inhibitory KIRs, which have long tails [7]. The KIR gene structure is flanked by KIR3DL3 and KIR3DL2 at the centromeric and at the telomeric end respectively, both of them exist on virtually all haplotypes [5].…”

“…There is a diversity in KIR genes content among populations [8]. Association of KIR gene polymorphisms was identified in several autoimmune diseases, such as psoriatic arthritis [9], psoriasis [10], rheumatoid arthritis [11], scleroderma [12], endometriosis [13], primary sclerosing cholangitis [14], Behcet's disease [15], and systemic lupus erythematosus [16]. Also, several studies have reflected an association between the KIR genes and infectious diseases [17,18], cancer [19,20], and disorders of the reproductive system [21,22].…”