Background: Postpartum depression is a mood disorder that occurs in the first year after childbirth, which affects mothers, babies and their families. The prevalence of postpartum depression is estimated to be 10-15% worldwide. Postpartum women who have weak social support are at risk for postpartum depression. This study aimd to estimate the strength of the relationship between social support and postpartum depression based on the results of previous similar studies. Subjects and Method: This research is a systematic review and meta-analysis. Meta analysis is carried out by systematically reviewing articles published from 2010 to 2020 from the Pubmed, Google Scholar, Science Direct, and Spinger Link databases using search keywords, namely "social support" OR "family support" OR "partner support" AND" postpartum depression "OR" postnatal depression "AND" cross sectional "AND" multivariate. Article searches were carried out using PICO. The study population was postpartum women, intervention/ exposure was weak social support with comparison was strong social support and the outcome was postpartum depression. The search for articles was carried out for one month. The articles included in this study were full text articles with cross sectional design. Articles were reviewed using the PRISMA flow diagram guidelines. Articles analyzed using Revman 5.3 Software. Results: 12 articles were reviewed in this study. This study shows that weak social support increased the risk of postpartum depression (aOR = 2.64; 95% CI: 2.08 - 3.35; p <0.001). Conclusion: Weak social support increases the risk of postpartum depression. Conclusion: Weak social support increases the risk of postpartum depression. Keywords: social support, postpartum depression Correspondence: Ardiani. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: dhiniardiani@gmail.com. Telepon: 085337742831.