Association between lactic acid sting test scores, self‐assessed sensitive skin scores and biophysical properties in Chinese females

Ding, Daixin; Tu, Ying; Man, Mao‐Qiang; Wu, Wenjuan; Lu, Fengyan; Li, X.; Li, Y.; Yang, Jianting; Yuan, Jing; Yang, Cheng

doi:10.1111/ics.12550

Cited by 22 publications

(35 citation statements)

References 37 publications

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“…Tests based on provocation with chemical irritants are invasive and may be unpleasant for some people. On the other hand, the available self‐reported perceptions or scales do not appear particularly suitable for diagnosis 20‐22 …”

Section: Discussionmentioning

confidence: 99%

Proposal of a self‐assessment questionnaire for the diagnosis of sensitive skin

Corazza

Guarneri

Montesi

et al. 2021

J of Cosmetic Dermatology

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Background Sensitive skin is very common and distressing. Its diagnosis may be difficult with the tools/methods available at the moment. Aims To assess the reliability of a self‐assessment questionnaire for the diagnosis of sensitive skin, using the results of lactic acid stinging test (LAST) as a reference for the identification of subjects suffering from this condition. A further objective was to identify the questionnaire cutoff score that better discriminates between subjects with or without sensitive skin. Patients/methods Among the adult volunteers included in this observational, cross‐sectional study, both LAST‐positive subjects, who were considered as having sensitive skin (“patients”), and negative ones (“controls”) completed the questionnaire. It consisted of a part for self‐assessing and quantifying (0–10) sensitive skin and another one that included 10 items, each referring to a specific, potentially triggering stimulus. A cumulative score (questionnaire‐based skin sensitivity score, 0–10) was calculated from the sum of all items considered capable of triggering unpleasant skin sensations in real‐life experience. Results One hundred and sixty‐two subjects were enrolled, 102 patients and 60 controls; 98 subjects thought they had sensitive skin. The mean questionnaire‐based skin sensitivity score was significantly higher among patients than controls and correlated with skin sensitivity self‐assessments. A cutoff value of 3 was set for the identification of LAST‐positive subjects, with 79% accuracy. Conclusions The study self‐assessment questionnaire seems to be a reliable tool for diagnosing sensitive skin in clinical practice. These results led us to identify a numerical cutoff for detecting propensity to experience sensitive skin.

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Section: Discussionmentioning

confidence: 99%

Proposal of a self‐assessment questionnaire for the diagnosis of sensitive skin

Corazza

Guarneri

Montesi

et al. 2021

J of Cosmetic Dermatology

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“… 45 The positive correlation between LAST stinging scores and TEWL was also observed in the previous studies of healthy Asian females 27 , 45 and Chinese women with sensitive skin. 14 Lactic acid is a small molecule chemical irritant that triggers neurosensory perceptions of stinging, burning, itching, or even pain when contact is made with the skin. The increased penetration of lactic acid caused a higher LAST score to predict sensitive skin.…”

Section: Discussionmentioning

confidence: 99%

“… 13 In addition, some researchers investigated the correlation of skin parameters and LAST only in sensitive population. 14 , 15 Thus, we aimed to elucidate the different biophysical properties of questionnaire- and LAST-assessed sensitive skin by noninvasive instruments, and the relationship between questionnaire and LAST scores with the biophysical parameters on both the healthy and sensitive populations.…”

Section: Introductionmentioning

confidence: 99%

Questionnaire and Lactic Acid Sting Test Play Different Role on the Assessment of Sensitive Skin: A Cross-sectional Study

Pan¹,

Ma²,

Song³

et al. 2021

CCID

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Background Questionnaires and lactic acid sting test (LAST) are two widely used methods to identify sensitive skin. However, the self-perceived sensitive skin by questionnaires was not consistent with the determination of LAST. Objective The aim of the study was to measure the biophysical properties noninvasively of sensitive skin evaluated by questionnaire and LAST and to investigate their correlations with the scores of questionnaire and LAST. Methods A total of 209 healthy Chinese females completed the study. Self-assessment questionnaire and LAST were both performed to identify sensitive skin. Epidermal biophysical properties, including skin hydration, transepidermal water loss (TEWL), sebum content, erythema index (EI), a* value, L* value, skin elasticity, and skin pH, were measured with noninvasive instruments. Results The frequency of sensitive skin was 50.2% and 66.0% by questionnaire and LAST, respectively. Subjects with self-assessed sensitive skin had a slightly higher LAST positive rate. Skin hydration, sebum content, a* and EI values were significantly higher in the self-assessed sensitive skin group, while TEWL, a* and EI values increased but L* value decreased with significance in the LAST positive group. The LAST stingers among sensitive skin subjects had higher EI but not in the healthy skin subjects. In addition, questionnaire scores positively correlated with skin hydration, sebum content, a* and EI values, while a positive relationship of LAST scores with TEWL, a* and EI values was observed. The scores of questionnaire and LAST both negatively related to L* value. Conclusion Self-assessed questionnaire is associated with sensitive skin featured by oily and red face without impaired barrier function, whereas LAST is suitable to identify fragile skin barrier and enhanced blood flow on the face. Combination of both methods to diagnose sensitive skin might be more reliable.

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“…Calming efficacy was evaluated in 30 volunteers aged 21 to 67 years with dry and reactive skin and known positivity to the lactic acid stinging test [12]. Stinging was induced on D0, D7 and D28 by rubbing a cotton pad impregnated with 10% lactic acid onto one half of the nasolabial fold (randomized for each subject).…”

Section: Skin Calming Effectmentioning

confidence: 99%

Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies

Granger

Brown²,

Aladren

et al. 2020

Dermatol Ther (Heidelb)

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Introduction: Extrinsic factors, such as solar radiation and urban pollution, cause damage that alters the structure, function and appearance of skin. The aim of this study was to determine the ability of a night cream containing melatonin, carnosine and Helichrysum italicum extract (referred to here as Night Cream) to reduce extrinsic skin damage, and to evaluate the efficacy of this Night Cream to reduce clinical signs of age and photodamage under normal conditions of use. Methods: Recovery from extrinsic damage was assessed by exposing human skin explants to ultraviolet (UV) A, infrared light, blue light or pollution and then treating the stress-exposed explants with Night Cream. Markers of oxidative stress were examined by immunohistochemistry. Anti-aging and calming properties were determined in four single-center, open-label trials involving 117 individuals. Subjects applied Night Cream to their face once nightly for up to 12 weeks. Improvements in clinical signs of age and photodamage, and reduction of lactic acid-induced stinging were evaluated by investigator assessment and subject selfassessment. Results: Night Cream significantly reduced oxidative stress in human skin ex vivo. Clinically, hydration (? 64.4%; p \ 0.05) and transepidermal water loss (TEWL) values (-10.0%; p \ 0.05) were improved within 1 h of use. Wrinkle counts were reduced by up to 18.9% (p \ 0.05), and brown and UV spot numbers by 5.5% (p \ 0.05) and 13.2% (p \ 0.05), respectively. Lactic acid-induced stinging was significantly reduced within 7 days of use, with 86.7% of subjects reporting that their skin felt calmer. Conclusion: These findings suggest that Night Cream reduces skin damage caused by environmental factors and that its nightly use can improve clinical signs of aging with additional skin calming benefits.

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Association between lactic acid sting test scores, self‐assessed sensitive skin scores and biophysical properties in Chinese females

Cited by 22 publications

References 37 publications

Proposal of a self‐assessment questionnaire for the diagnosis of sensitive skin

Proposal of a self‐assessment questionnaire for the diagnosis of sensitive skin

Questionnaire and Lactic Acid Sting Test Play Different Role on the Assessment of Sensitive Skin: A Cross-sectional Study

Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies

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