Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study

Ding, Changhai; Parameswaran, V.; Cicuttini, Flavia Maria; Burgess, John; Zhai, Guangju; Quinn, Stephen; Jones, Graeme

doi:10.1136/ard.2007.082651

Cited by 80 publications

(82 citation statements)

References 27 publications

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“…Should the individual be less affected by pain, there is less likelihood that a medical practitioner may determine a need for radiology services, reducing the likelihood of diagnosis. Obesity is the strongest modifiable predictor of arthritis onset and progression, especially knee osteoarthritis (13), and increases the likelihood of reduced cartilage volume (32), the hallmark characteristic of arthritis. Given that physical activity is an important predictor of obesity, this is worthy of discussion in the context of social determinants.…”

Section: Discussionmentioning

confidence: 99%

Neighborhood disadvantage, individual‐level socioeconomic position, and self‐reported chronic arthritis: A cross‐sectional multilevel study

Brennan¹,

Turrell²

2012

Arthritis Care & Research

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Objective. To examine the association between individual-and neighborhood-level disadvantage and self-reported arthritis. Methods. We used data from a population-based cross-sectional study conducted in 2007 among 10,757 men and women ages 40 -65 years, selected from 200 neighborhoods in Brisbane, Queensland, Australia using a stratified 2-stage cluster design. Data were collected using a mail survey (68.5% response). Neighborhood disadvantage was measured using a census-based composite index, and individual disadvantage was measured using self-reported education, household income, and occupation. Arthritis was indicated by self-report. Data were analyzed using multilevel modeling. Results. The overall rate of self-reported arthritis was 23% (95% confidence interval [95% CI] 22-24). After adjustment for sociodemographic factors, arthritis prevalence was greatest for women (odds ratio [OR] 1.5, 95% CI 1.4 -1.7) and in those ages 60 -65 years (OR 4.4, 95% CI 3.7-5.2), those with a diploma/associate diploma (OR 1.3, 95% CI 1.1-1.6), those who were permanently unable to work (OR 4.0, 95% CI 3.1-5.3), and those with a household income <$25,999 (OR 2.1, 95% CI 1.7-2.6). Independent of individual-level factors, residents of the most disadvantaged neighborhoods were 42% (OR 1.4, 95% CI 1.2-1.7) more likely than those in the least disadvantaged neighborhoods to self-report arthritis. Cross-level interactions between neighborhood disadvantage and education, occupation, and household income were not significant. Conclusion. Arthritis prevalence is greater in more socially disadvantaged neighborhoods. These are the first multilevel data to examine the relationship between individual-and neighborhood-level disadvantage upon arthritis and have important implications for policy, health promotion, and other intervention strategies designed to reduce the rates of arthritis, indicating that intervention efforts may need to focus on both people and places.

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Section: Discussionmentioning

confidence: 99%

Neighborhood disadvantage, individual‐level socioeconomic position, and self‐reported chronic arthritis: A cross‐sectional multilevel study

Brennan¹,

Turrell²

2012

Arthritis Care & Research

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“…Synovial fluid leptin levels were correlated with radiographic knee OA severity,35 and serum leptin levels were associated with higher odds of radiographic knee OA in the National Health and Nutrition Examination Survey III36 and among middle-aged women 37. Leptin has a demonstrated catabolic role on bovine cartilage through inflammatory mechanisms38 and greater cartilage degradation indices,13 and less cartilage volume25 have been associated with higher serum leptin levels in some but not all39 studies.…”

Section: Introductionmentioning

confidence: 99%

The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women

et al. 2013

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Background and Objective Serum leptin measures are associated with radiographic knee osteoarthritis but no studies have examined leptin levels with respect to different measures of knee joint damage from magnetic resonance imaging (MRI). Methods Participants in the Michigan Study of Women’s Health Across the Nation underwent bilateral knee MRIs at follow-up visit 11 for assessment of cartilage defects, bone marrow lesions, osteophytes, meniscal tears, synovitis and joint effusion. Serum leptin measures were available from baseline, follow-up visits 1 and 3–7. Results Baseline serum leptin levels were associated with greater odds of having more severe knee joint damage at follow-up visit 11 after adjustment for age, smoking status, menopause status and BMI residuals. The greatest effect was observed for osteophytes; a 5 ng/mL increase in baseline leptin was associated with 24% higher odds of having larger osteophytes (95% CI 1.17, 1.32). Correlations with baseline serum leptin were greatest for MRI-assessed osteophytes (r=0.41), followed by followed by effusion (r=0.32), synovitis (r=0.30), cartilage defects (r=0.28), bone marrow lesions (r=0.24) and meniscal abnormalities (r=0.21). Conclusions Leptin levels ten years prior to MRI assessment were associated with the presence of cartilage defects, bone marrow lesions, osteophytes, meniscal tears, synovitis and effusion among a population of mid-aged women. Understanding the role that leptin plays in the joint degradation process is critical for development of more targeted interventions for osteoarthritis.

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“…Using MRI, we have demonstrated that serum levels of leptin are associated with reduced knee cartilage volume, and the associations between obesity measures, female sex and cartilage volume are largely mediated by leptin. 9 In another study on hip OA, we have reported that positive associations between body composition and hip joint space narrowing ( JSN) are also mediated by leptin, particularly in women. 10 As causal inference cannot be obtained from cross-sectional studies, a prospective design is needed to test if leptin plays a role in cartilage degradation.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults

et al. 2013

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Objective To investigate cross-sectional and longitudinal associations between serum leptin levels and knee cartilage thickness in older adults. Methods A prospective cohort of 163 randomly selected subjects (mean 63 years, range 52-78, 46% women) was studied. Knee cartilage thickness at medial tibial, lateral tibial, femoral and patellar sites was determined using T1-weighted fat-suppressed MRI. Serum leptin levels were measured by radioimmunoassay. Radiographic osteoarthritis, body fat (%), trunk fat (%), weight and height were measured, and body mass index (BMI) was calculated. Results Cross-sectionally, serum levels of leptin were negatively associated with femoral (β: −0.013, 95% CI −0.022 to −0.003), medial tibial (β: −0.009, 95% CI −0.018 to −0.001), lateral tibial (β: −0.012, 95% CI −0.021 to −0.003) and patellar (β: −0.014, 95% CI −0.026 to −0.002) cartilage thickness after adjustment for covariates. Moreover, BMI, trunk fat and total body fat were negatively associated with cartilage thickness, and the significant associations disappeared after further adjustment for leptin. Longitudinally, both baseline leptin and change in leptin were associated with greater changes in medial tibial cartilage thickness (β: −0.004, 95% CI −0.007 to −0.001 and β: −0.009, 95% CI −0.018 to −0.001, respectively) in multivariable analyses. Conclusions Serum levels of leptin are independently and consistently associated with reduced cartilage thickness cross-sectionally and longitudinally. In addition, the associations between adiposity measures and cartilage thickness are mediated by leptin, suggesting leptin may play a key role in cartilage thinning.

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Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study

Cited by 80 publications

References 27 publications

Neighborhood disadvantage, individual‐level socioeconomic position, and self‐reported chronic arthritis: A cross‐sectional multilevel study

Neighborhood disadvantage, individual‐level socioeconomic position, and self‐reported chronic arthritis: A cross‐sectional multilevel study

The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women

Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults

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