Association between leptin gene polymorphisms and growth traits in Limousin cattle

Kulig, H.; Kmiec, M.

doi:10.1134/s1022795409060131

Cited by 33 publications

(34 citation statements)

References 9 publications

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“…Buchanan et al (2002) studied an SNP in exon 2 of the leptin gene and demonstrated its association with carcass fat. In addition, a polymorphism in exon 3 of the leptin gene is related to body weight at 210 days of age and the average daily gain between 3 and 210 days of age in Limousin calves (Kulig and Kmieć, 2009). Guo et al (2008b) also reported an association between a polymorphism of the leptin receptor and growth traits in Nanyang cattle, in contrast to our results.…”

Section: Discussioncontrasting

confidence: 55%

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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ABSTRACT. Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal's life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which influence BFT and REA in Canchim cattle, a composite beef breed (5/8 Charolais + 3/8 Zebu). BFT and REA phenotypic records were obtained by ultrasound measurements from 18-month-old animals. All SNP markers were genotyped by restriction fragment length polymorphismpolymerase chain reaction. Restricted maximum likelihood analysis revealed that the non-synonymous SNP located in exon 2 of the FABP4 gene has an additive effect on BFT (P ≤ 0.05). Significant allele substitution 16668©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16667-16674 (2015) G. Veneroni-Gouveia et al. effects showed that the substitution of G by A may lead to a decrease of 0.1055 mm in mean BFT. This information can be used for inclusion of this trait-associated marker in commercial SNP panels.

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Section: Discussioncontrasting

confidence: 55%

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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“…SNP-1457 (AJ571671:g.-1457A>G) in the leptin gene promoter region has been associated with fertility and growth in the Holstein breed (Liefers et al, 2005;Clempson et al, 2011). The polymorphism A59V (AF536174.1:g. 321C>T) in exon 3 of the leptin gene has been associated with weight and average daily body weight gains in beef cattle (Kulig and Kmieć, 2009). Previous studies of the microsatellite BM1500 (located 3.9 kb downstream of the leptin gene) showed its association with carcass fat deposition in beef cattle (Fitzsimmons et al, 1998;Montoya et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…However, SNP A59 significantly affected the body weight of 210-day-old Limousin breed and the average daily gains between 3-and 210-day-old breed (Kulig and Kmieć, 2009). SNP -1457 was associated with the first luteal activity post-partum and weight during lactation in the Holstein-Friesian breed (Liefers et al, 2005).…”

Section: Association Analysismentioning

confidence: 99%

“…The single nucleotide polymorphisms (SNPs) detected in the leptin gene and its receptors have been associated with carcass traits and serum leptin concentrations in different species, particularly bovines (Nkrumah et al, 2005;Kulig and Kmieć, 2009;Orrù et al, 2011;da Silva et al, 2012). SNP-1457 (AJ571671:g.-1457A>G) in the leptin gene promoter region has been associated with fertility and growth in the Holstein breed (Liefers et al, 2005;Clempson et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Genetic variations in the leptin gene associated with growth and carcass traits in Nellore cattle

Silva¹,

Crispim²,

Silva³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The aim of the study was to detect polymorphisms in the leptin gene and to determine the association of these polymorphisms with growth and carcass traits in Nellore cattle. The single nucleotide polymorphisms (SNPs) -1457 (AJ571671:g.-1457A>G) and A59V (AF536174.1:g. 321C>T), as well as the microsatellite BM1500 (3.9 kb downstream), were genotyped. The measures of body weight and ultrasound examinations (rib eye area, back, and rump fat thickness) were performed in 3 different periods of animal management. During the first period, the animals were fed with grass and mineralized salt ad libitum. In the second period, they received grass and concentrate, and in the third, only concentrate. After the slaughter of animals, data were collected for classification and typification of carcasses. No significant association was found between the variables assessed and SNP -1457. Conversely, SNP A59V was associated with rump fat thickness and muscle color post-slaughter. BM1500 was associated with rump fat thickness in the first period (pre-slaughter), subcutaneous fat thickness 3003 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (2): 3002-3012 (2014) Leptin gene variations in Nellore cattle in the second, weight of the animals in the third, and length of the carcass after slaughter. These results suggest that SNP A59V and the microsatellite BM1500 might be useful for marker-assisted selection in Nellore cattle.

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“…Yang et al (2007) reported that leptin may be a candidate gene for growth traits such as height at hip cross and was applied to MAS in Chinese cattle breeds. Kulig and Kmieć (2009) showed that the average daily weight gain between 3 and 210 days of age was significantly higher in Limousin cattle possessing the CT/CT haplotype compared with those possessing the CC/CC and CC/CT haplotypes for the A59V polymorphism in exon 3 of the leptin gene. Clempson et al (2011) discovered that four leptin SNPs (A1457G, A59V, UASMS1, UASMS2) were associated with different types of growth performance in Holstein cows.…”

Section: Discussionmentioning

confidence: 99%

Association study between single nucleotide polymorphisms in leptin and growth traits in Cyprinus carpio var. Jian

Tang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Leptin is a hormone that affects the regulation of body weight, energy expenditure, fat metabolism, food intake, and appetite. In this study, we cloned the jlLEP-A1 and jlLEP-A2 genes in Jian carp (Cyprinus carpio var. Jian) and performed an association analysis between identified polymorphisms and growth traits. Three polymorphisms in exons of jlLEP-A1 (A1-T113C) and jlLEP-A2 (A2-G415A and A2-G427A) were identified, and genotyped by the polymerase chain reaction -restriction fragment length polymorphism method in 263 female and 294 male Jian carp. All three SNPs were missense mutations. Association analysis revealed that the three SNPs were significantly associated with growth traits in male Jian carp. Only SNP A1-T113C was significantly associated with growth traits in female Jian carp. Analysis of diplotypes derived from jlLEP-A2 SNPs revealed an association with growth traits in male but not female Jian 2 Y. Tang et al. Genetics and Molecular Research 15 (3): gmr.15037635 carp. These results demonstrate that polymorphisms in the leptin gene are associated with growth traits and may be used for marker-assisted selection programs in Jian carp breeding and production.

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Association between leptin gene polymorphisms and growth traits in Limousin cattle

Cited by 33 publications

References 9 publications

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Genetic variations in the leptin gene associated with growth and carcass traits in Nellore cattle

Association study between single nucleotide polymorphisms in leptin and growth traits in Cyprinus carpio var. Jian

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