Association Between Lipid Profiles and Left Ventricular Hypertrophy: New Evidence from a Retrospective Study

Huang, Xuewei; Deng, Ke‐Qiong; Qin, Jianghui; Lei, Fang; Zhang, Xingyuan; Wang, Wenxin; Lin, Lijin; Zheng, Yuming; Yao, Dongai; Lü, Hongyan; Liu, Feng; Lidong, Chen; Zhang, Guilan; Liu, Yueping; Yang, Qiong-Yu; Cai, Jingjing; She, Zhi‐Gang; Li, Hongliang

doi:10.24920/004066

Cited by 5 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, to our knowledge, a previous study only showed an association between Lp(a) and LVH assessed by echocardiography in patients with acute myocardial infarction ( 21 ), whereas the correlation between Lp(a) and LVH in the general population remains unclear, especially for LVH diagnosed by ECG. Recently, a large observational epidemiological study involving 309,400 participants showed that Lp(a) in the highest tertile was significantly associated with a higher prevalence of LVH diagnosed by echocardiography compared with Lp(a) in the lowest tertile, but not with a higher incidence of LVH during follow-up ( 36 ). Although this study demonstrated in the cross-sectional section that participants in the highest tertile of Lp(a) had a 1.3 times higher risk of developing LVH compared with those in the lowest tertile, because LVH in this study was defined by expensive and highly subjective echocardiography, the results may not be applicable to large epidemiological studies based on the general population.…”

Section: Discussionmentioning

confidence: 99%

Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study

Yan,

Gong,

Wang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Background and aimsIncreasing evidence supports a causal relationship between lipoprotein(a) [Lp(a)] and atherosclerotic cardiovascular disease, yet its association with left ventricular hypertrophy (LVH) assessed by electrocardiogram (ECG) remains unknown. The aim of this study was to explore the relationship between Lp(a) and LVH assessed by ECG in general population.Methods and resultsIn this cross-sectional study, we screened 4,052 adults from the participants of the third National Health and Nutrition Examination Survey for analysis. Lp(a) was regarded as an exposure variable. LVH defined by the left ventricular mass index estimated from ECG was considered as an outcome variable. Multivariate logistic regression and restricted cubic spline (RCS) were used to assess the relationship between Lp(a) and LVH. Individuals with LVH had higher Lp(a) compared to individuals without LVH (P< 0.001). In the fully adjusted model, Lp(a) was strongly associated with LVH when as a continuous variable (per 1-unit increment, OR: 1.366, 95% CI: 1.043-1.789, P = 0.024), and higher Lp(a) remained independently associated with a higher risk of LVH when participants were divided into four groups according to quartiles of Lp(a) (Q4 vs Q1, OR: 1.508, 95% CI: 1.185-1.918, P = 0.001). And in subgroup analysis, this association remained significant among participants< 60 years, ≥ 60 years, male, with body mass index< 30 kg/m2, with hypertension and without diabetes (P< 0.05). In addition, we did not observe a nonlinear and threshold effect of Lp(a) with LVH in the RCS analysis (P for nonlinearity = 0.113).ConclusionLp(a) was closely associated with LVH assessed by ECG in general population.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study

Yan,

Gong,

Wang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Association of lipoprotein(a) with left ventricular hypertrophy in patients with new-onset acute myocardial infarction: A large cross-sectional study

Wang

Xiao

Liu

2023

Clinica Chimica Acta

View full text Add to dashboard Cite

Colchicine effect on biomarkers of cardiac remodelling and atherosclerosis in ST‐elevation myocardial infarction: A randomized controlled trial

Hassanain,

El Wakeel,

Khorshid

et al. 2024

Brit J Clinical Pharma

View full text Add to dashboard Cite

AimsOwing to its underlying inflammatory nature, atherosclerotic cardiovascular disease remains the leading global cause of mortality, particularly post‐ST‐elevation myocardial infarction (STEMI), a condition with significant risk for further cardiovascular events and mortality. This study aimed to investigate colchicine's effect on inflammation, cardiac remodelling and atherosclerotic risk in STEMI patients.MethodsWe conducted a randomized controlled study on 88 STEMI patients undergoing percutaneous coronary intervention. Eligible patients were randomly assigned to 1 of 2 groups. The control group received the guideline‐directed medical therapy for STEMI, and the test group received guideline‐directed medical therapy and 0.5 mg colchicine twice daily for 3 months. The soluble suppressor of tumorigenicity (sST2), interleukin‐1β, lipid profile parameters, triglyceride (TG)/high‐density lipoprotein (HDL‐C) ratio levels and left ventricular ejection fraction were evaluated for patients at baseline and the end of the 3 months.ResultsNo significant effects were reported for colchicine on sST2, interleukin‐1β levels or left ventricular ejection fraction. Colchicine significantly lowered TG levels vs. controls, 134 (46–353) vs. 176 (72–825) respectively, P = .02, as well as TG/HDL‐C ratio levels, 4.16 (2.75–5.24) vs. 5.11 (3.51–8.33),` respectively, P = .024. sST2 levels of the studied cohort were positively correlated with their TG/HDL‐C ratio levels (R = .459, P < .001) at the end of follow‐up.ConclusionOur study highlights a promising impact of colchicine on atherosclerosis and cardiac remodelling factors in STEMI patients. Colchicine significantly reduced TG levels and TG/HDL‐C ratio and was safe and well tolerated. Larger long‐term studies powered to assess clinical outcomes of remodelling are necessary to confirm its beneficial effects in STEMI.Clinicaltrial.gov registration IDNCT06054100.

show abstract

Association Between Lipid Profiles and Left Ventricular Hypertrophy: New Evidence from a Retrospective Study

Cited by 5 publications

References 45 publications

Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study

Association of lipoprotein(a) with left ventricular hypertrophy assessed by electrocardiogram in adults: a large cross-sectional study

Association of lipoprotein(a) with left ventricular hypertrophy in patients with new-onset acute myocardial infarction: A large cross-sectional study

Colchicine effect on biomarkers of cardiac remodelling and atherosclerosis in ST‐elevation myocardial infarction: A randomized controlled trial

Contact Info

Product

Resources

About