Association between lipid ratio and depression: a cross-sectional study

Abstract

Depression is associated with total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol levels in the blood. However, evidence is limited on the relationship between depression and lipid ratios. Therefore, this study aimed to investigate the correlation between depression and different lipid ratios. This study was conducted using data from the Korea National Health and Nutrition Examination Survey. A total of 11,648 adult men and women aged ≥ 19 years, without missing data, were included in this study. Depression was diagnosed using the Patient Health Questionnaire-9. The associations between depression and total cholesterol/high-density lipoprotein cholesterol, low-density cholesterol/high-density lipoprotein cholesterol, and triglyceride/high-density lipoprotein cholesterol ratio were analyzed. A complex sample logistic regression test was used for the analysis of the odds ratios of depression. Among men, the total cholesterol/high-density lipoprotein cholesterol and low-density cholesterol/high-density lipoprotein cholesterol ratios were not associated with depression. Additionally, an increase in triglyceride/high-density lipoprotein cholesterol ratio by 1 was associated with a 1.041-fold higher probability of depression in men. Among women, the three lipid ratios were not associated with depression. Triglyceride/high-density lipoprotein cholesterol ratio is associated with depression among men. Future studies should cross-validate, explore the biological mechanism, and identify the clinical implication of this correlation.

Identification of Potential Protein Biomarkers in a Depressed Chinese Malaysian University Student Using Liquid Chromatography-Tandem Mass Spectrometry

“…Past studies showed that low-density lipoprotein (LDL) cholesterol levels are associated with depression [23][24][25]. LDL cholesterol can reduce the availability of serotonin and increase depression risk [26] by directly impairing the function of the serotonin 1A receptor in the brain. Activation of this receptor is associated with many other neurotransmitters related to the recovery and repair of neurons, as well as depression [27].…”

Association between Physical Activity Level with Depression, Anxiety, and Stress in Dyslipidaemia Patients

“…Dyslipidaemia is a significant risk factor for cardiovascular diseases (CVD), which is a leading cause of death globally, resulting in 17.9 million deaths annually (WHO, 2023). Dyslipidemia increases inflammatory markers in the body, resulting in an increased risk of depression and other mental health issues (Chuang et al, 2014;Han, 2022). The prevalence of mental health issues such as depression, anxiety, and stress are on the rise in the world, and Malaysia is witnessing the same trend.…”

MRASin coronary artery disease—Unchartered territory

“…It has been shown that cardiac risk factor prevalence (e.g., hyperlipidemia, hypertension, and diabetes) significantly increases with increasing body mass index (BMI) [62][63][64] and a BMI above 30 is a risk factor for early development of CAD. 62 Several noncoding SNVs in the MRAS locus were identified to be significantly associated with obesity-related traits, including BMI, body fat percentage, or waist-to-hip ratio (Table 1).…”

“…50 In addition, rs6782181 was reported to be associated with dyslipidemia in Chinese Han and Mulao populations in an ethnic-and sex-specific manner. 54,63,64 Another SNV, rs253662, is also implicated in patients with reduced HDL levels. Interestingly, both rs253662 and rs6782181 are protective against acquiring high lowdensity lipoproteins and are associated with CAD.…”

“…The rs6782181 SNV was also identified as common to CAD, obesity, and dyslipidemia trait when analyzed independently, as well as following correction for confounding factors 50 . In addition, rs6782181 was reported to be associated with dyslipidemia in Chinese Han and Mulao populations in an ethnic‐ and sex‐specific manner 54,63,64 …”