Association between lipocalin-2 levels and diabetic retinopathy in patients with overweight/obese type 2 diabetes mellitus

Zhang, Yajuan; Song, Xiaojun; Gao, Shan; Sun, Chao; Yang, Jiaxuan; Zhou, Xinjie

doi:10.1007/s11845-023-03365-y

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Lipocalin-2 has been studied foremost in obese/overweight patients and type 2 diabetes showing association to retinopathy [ 15 , 16 ] but significantly correlation with a decreased glomerular filtration rate has been shown in young adults with typ1 1 diabetes [ 26 ]. MMP-9, as a marker of tissue damage, has been shown to increase in patients with longer diabetes duration [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lipocalin-2 is a novel adipokine which has been shown to relate to the level of inflammation in diseases and therefore linked to obesity and insulin resistance [ 14 ] Correlation between lipocalin-2 and vascular endothelial growth factor has been found in patients with proliferative diabetes retinopathy [ 15 ] and to retinopathy in patients with diabetes and overweight/obesity [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes

Nilsson,

Dereke

2024

J Diabetes Metab Disord

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Purpose Complications from diabetes mellitus can occur over time and although glycosylated hemoglobin (HbA1c) is a good biomarker for glycaemic control, other factors also contribute to the development of complications in type 1 diabetes. More markers able to identify the risk of complications are needed. This study aimed to investigate plasma levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 in children and adolescents with different duration of type 1 diabetes and possible correlation to HbA1c to identify potential biomarkers of future complication development. Methods Patients (n = 244, 0–18 years) with type 1 diabetes, at Helsingborg’s Hospital, Sweden, were included in this study. Circulating levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 were investigated in plasma using automated ELISA with the ELLA™ system and standardised controls. Results Cystatin C levels were elevated in patients with diabetes duration longer than 5 years (P < 0.001). HbA1c and Cystatin C levels were inversely correlated for all participants (rs = − 0.23, CI95: −0.35-−0.10; P < 0.001). A stepwise multiple regression analysis showed that HbA1c (P < 0.001) and Cystatin C (P = 0.03) were associated to the duration of diabetes at sampling while MMP-9, lipocalin-2, and FGF21 did not reach statistical significance. Conclusion In conclusion, Cystatin C levels were higher in patients with diabetes duration longer than 5 years, and inverse correlation was found between HbA1c and Cystatin C levels as well as duration of diabetes. Cystatin C may prove useful as an adjunct to HbA1c in predicting eventual development of diabetic complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes

Nilsson,

Dereke

2024

J Diabetes Metab Disord

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Molecular-Genetic Biomarkers of Diabetic Macular Edema

Andrés-Blasco,

Gallego-Martínez,

Casaroli-Marano

et al. 2024

JCM

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Background: Diabetic macular edema (DME) is a leading cause of vision impairment and blindness among diabetic patients, requiring effective diagnostic and monitoring strategies. This systematic review aims to synthesize current knowledge on molecular biomarkers associated with DME, focusing on their potential to improve diagnostic accuracy and disease management. Methods: A comprehensive search was conducted in PubMed, Embase, Medline, and the Cochrane Central Register of Controlled Trials, covering literature from 2004 to 2023. Out of 1074 articles initially identified, 48 relevant articles were included in this systematic review. Results: We found that molecules involved in several cellular processes, such as neuroinflammation, oxidative stress, vascular dysfunction, apoptosis, and cell-to-cell communication, exhibit differential expression profiles in various biological fluids when comparing diabetic individuals with or without macular edema. Conclusions: The study of these molecules could lead to the proper identification of specific biomarkers that may improve the diagnosis, prognosis, and therapeutic management of DME patients.

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Association between lipocalin-2 levels and diabetic retinopathy in patients with overweight/obese type 2 diabetes mellitus

Cited by 2 publications

References 38 publications

Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes

Cystatin C as an adjunct to HbA1c may prove useful in predicting the development of diabetic complications in children and adolescents with type 1 diabetes

Molecular-Genetic Biomarkers of Diabetic Macular Edema

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