Association between Lipoprotein Lipase Polymorphism and the Risk of Stroke: A Meta-analysis

He, Tao; Wang, Jie; Deng, Wenshuai; Sun, Peng

doi:10.1016/j.jstrokecerebrovasdis.2017.06.003

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…[48] Huang et al [27] firstly investigated the genetic association between HindIII (+/−) variant and stroke, and obtained negative results. This result was followed by Song et al, [30] Velásquez Pereira et al, [22] and Xu et al [28] Although negative results were observed in individual study, our study confirmed this variant in allelic and dominant models were associated with a significant reduction of the IS risk especially in Asian population, which was similar with the results reported in latest publication by He et al [51] Notable, we included 2 more studies [30,37] and found that the recessive model of HindIII (+/−) might not be the susceptible factor of IS, which was partly different from that reported by He et al [51] In addition, we excluded 3 studies [52–54] that included in study conducted by He et al on the association between the HindIII (+/−) and hemorrhagic stroke (HS) risk for the present meta-analysis mainly focused on the association between HindIII (+/−) and IS risk. Recent studies suggested that HS and IS were 2 different subtype of stroke.…”

Section: Discussionsupporting

confidence: 92%

The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS)

Cao

Li²,

Xu³

2018

Medicine

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Section: Discussionsupporting

confidence: 92%

The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS)

Cao

Li²,

Xu³

2018

Medicine

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“…reported a lower risk of stroke among patients with HindIII polymorphisms with allele G (G vs T; OR=0.78, CI95%=0.70-0.87, p<0.001). This pattern was observed in patients with ischemic stroke (G vs T. OR=0.84, CI95%=074-0.95, p=0.005) and hemorrhagic stroke (G vs. T; OR=0.60, CI95%=0.48-0.74, p<0.001) 80 .…”

Section: Hindiii (Rs320) Polymorphismmentioning

confidence: 70%

Dyslipidemia: Genetics, lipoprotein lipase and HindIII polymorphism

et al. 2018

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The direct link between lipid metabolism alterations and the increase of cardiovascular risk are well documented. Dyslipidemias, including isolated high LDL-c or mixed dyslipidemia, such as those seen in diabetes (hypertriglyceridemia, high LDL-c or low HDL-c), correlate with a significant risk of cardiovascular and cerebrovascular disease worldwide. This review analyzes the current knowledge concerning the genetic basis of lipid metabolism alterations, emphasizing lipoprotein lipase gene mutations and the HindIII polymorphism, which are associated with decreased levels of triglycerides and LDL-c, as well as higher levels of HDL-c. These patterns would be associated with decreased global morbidity and mortality, providing protection against cardiovascular and cerebrovascular diseases.

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“…The presence of the HindIII polymorphism variant in the Asian population showed a decreased ischemic stroke risk, while the non-Asian population showed an increase in ischemic stroke risk [106].…”

Section: Discussionmentioning

confidence: 88%

The Role of Biomarkers in Atherothrombotic Stroke—A Systematic Review

Andone

Bajkó

Moţăţăianu

et al. 2021

IJMS

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Stroke represents the primary debilitating disease in adults and is the second-highest cause of death worldwide. Atherosclerosis, the most prevalent etiology for vascular conditions, is a continuous process that gradually creates and develops endothelial lesions known as atherosclerotic plaques. These lesions lead to the appearance of atherothrombotic stroke. In the last decades, the role of biological biomarkers has emerged as either diagnostic, prognostic, or therapeutic targets. This article aims to create a list of potential biomarkers related to atherothrombotic stroke by reviewing the currently available literature. We identified 23 biomarkers and assessed their roles as risk factors, detection markers, prognostic predictors, and therapeutic targets. The central aspect of these biomarkers is related to risk stratification, especially for patients who have not yet suffered a stroke. Other valuable data are focused on the predictive capabilities for stroke patients regarding short-term and long-term prognosis, including their influence over the acute phase treatment, such as rt-PA thrombolysis. Although the role of biomarkers is anticipated to be of extreme value in the future, they cannot yet compete with traditional stroke neuroimaging markers but could be used as additional tools for etiological diagnosis.

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Association between Lipoprotein Lipase Polymorphism and the Risk of Stroke: A Meta-analysis

Cited by 12 publications

References 39 publications

The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS)

The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS)

Dyslipidemia: Genetics, lipoprotein lipase and HindIII polymorphism

The Role of Biomarkers in Atherothrombotic Stroke—A Systematic Review

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