Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Abstract

Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility. Metaregression and publication bias analyses were also conducted. All analyses were performed using the Stata 12.0 software. Results. Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis. A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs. ins: OR = 0:79, 95%CI = 0:72-0:86; del/del vs. ins/ins+del/ins: OR = 0:74, 95%CI = 0:59-0:91; del/ins vs. ins/ins: OR = 0:84, 95%CI = 0:67-1:05). For rs16901904, a decreased cancer risk was observed in three genetic models (C vs. T: OR = 0:79, 95%CI = 0:70-0:90; CC vs. CT+TT: OR = 0:49, 95%CI = 0:37-0:65; CC vs. TT: OR = 0:49, 95%CI = 0:37-0:66). No statistical significance was found in the metaregression analysis. For all of the included SNPs, no publication bias was found in all genotype models. Conclusions. The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.

Association of Long Non-Coding RNA Polymorphisms with Gastric Cancer and Atrophic Gastritis

“…The possible role of different genetic alterations in the development of gastric cancer has been studied [ 13 , 14 , 15 ]. Recent studies found that lncRNAs single-nucleotide polymorphisms (SNPs) may be involved in the carcinogenesis of gastric cancer [ 16 , 17 ]. An increasing amount of data demonstrate that gastric cancer patients have different lncRNA serum profiles compared with healthy controls [ 18 ].…”

Association between long non-coding RNA (lncRNA) GAS5 polymorphism rs145204276 and cancer risk

“…Although two studies have reported that the GAS5 ins/del polymorphism was associated with a predisposition to GC, the findings were not robust. 42,43 In the present study, we conducted meta-analyses, in addition to TSA analyses, FPRP tests, and single-tissue eQTLs. These results strongly demonstrated that GAS5 polymorphism rs145204276 is associated with the susceptibility to gastrointestinal cancer.…”

Identification and characterization of functional long noncoding RNAs in cancer

“…52 The ANRIL locus is another example of a hotspot harboring more than 10 cancer risk SNPs, some of which are correlated with ANRIL expression. 53,54 Other lncRNAs linked to cancer SNPs include HOTAIR (HOX Transcript Antisense RNA), 55 HOTTIP (HOXA Distal Transcript Antisense RNA), 52 MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1), 52 HULC (Highly Upregulated in Liver Cancer), 52 MEG3 (Maternally Expressed 3), 56 H19, 57 GAS5 (Growth Arrest-Specific 5), 56 and PTENP1 (Phosphatase And Tensin Homolog Pseudogene 1). 58 Mechanistic investigations of SNPs associated with ln-cRNAs have suggested that the risk variants may, in some cases, affect regulatory DNA sequences, thereby resulting in altered lncRNA expression.…”