Association between long-term occupational manganese exposure and bone quality among retired workers

Li, Defu; Ge, Xiaoting; Liu, Zhenfang; Huang, Lulu; Zhou, Yanting; Liu, Peng; Qin, Lian; Lin, Suzhen; Liu, Chaoqun; Hou, Qingzhi; Li, Longman; Cheng, Hong; Ou, Songfeng; Fu, Wei; Shen, Yongchun; Zou, Yue; Yang, Xiaobo

doi:10.1007/s11356-019-06694-7

Cited by 20 publications

(11 citation statements)

References 38 publications

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“…On the contrary, a 2020 cross-sectional study by Li Defu highlighted how retired workers who were exposed to high doses of manganese during work may have a higher risk of developing osteoporosis than the female control sample population and compared to male workers exposed to the same doses of manganese [ 237 ]. This study involved 304 subjects exposed to high doses of manganese for more than 10 years (161 men and 143 women) and 277 control subjects who were retired workers, including 65 men and 212 women.…”

Section: Discussionmentioning

confidence: 99%

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

et al. 2021

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Bone is a nutritionally modulated tissue. Given this background, aim of this review is to evaluate the latest data regarding ideal dietary approach in order to reduce bone mineral density loss and to construct a food pyramid that allows osteopenia/osteoporosis patients to easily figure out what to eat. The pyramid shows that carbohydrates should be consumed every day (3 portions of whole grains), together with fruits and vegetables (5 portions; orange-colored fruits and vegetables and green leafy vegetables are to be preferred), light yogurt (125 mL), skim milk (200 mL,) extra virgin olive oil (almost 20 mg/day), and calcium water (almost 1 l/day); weekly portions should include fish (4 portions), white meat (3 portions), legumes (2 portions), eggs (2 portions), cheeses (2 portions), and red or processed meats (once/week). At the top of the pyramid, there are two pennants: one green means that osteopenia/osteoporosis subjects need some personalized supplementation (if daily requirements cannot be satisfied through diet, calcium, vitamin D, boron, omega 3, and isoflavones supplementation could be an effective strategy with a great benefit/cost ratio), and one red means that there are some foods that are banned (salt, sugar, inorganic phosphate additives). Finally, three to four times per week of 30–40 min of aerobic and resistance exercises must be performed.

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Section: Discussionmentioning

confidence: 99%

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

et al. 2021

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“…However, in a cross-sectional study of 304 retired workers with occupational manganese exposure, aiming to investigate the relationship between long-term occupational manganese exposure and bone quality, female participants in the highest manganese exposure group were significantly lower than the female control group in terms of stiffness index (SI) and T-score levels. This suggests that women with occupational manganese exposure may have a higher risk of osteoporosis [14]. Different sample sizes, inclusion and exclusion criteria, duration of follow-up, and different levels of manganese exposure may lead to different results between studies.…”

Section: Plos Onementioning

confidence: 99%

“…Evidence from animal study suggested that Mn accumulated in rat bones with an average elimination half-life of 143 days, equivalent to approximately 8.5 years in human bones [21]. Thus, bone may also be an ideal organ exploring toxicity which caused by long-term manganese exposure [14]. It has been previously reported that excessive manganese may be neurotoxic to humans, affecting specific areas of the central nervous system and producing irreversible neurological symptoms [26].…”

Section: Plos Onementioning

confidence: 99%

“…Significantly higher blood Mn levels have been revealed in women of US residents, Canadians, Koreans, Chinese general population, and Italians [14,[38][39][40][41][42]. Mining and iron as well as steel production are considered as occupational sources of manganese exposure.…”

Section: Plos Onementioning

confidence: 99%

“…Some previous studies have shown that women with osteoporosis have lower serum manganese levels than women with normal bone mineral density [13]. While a previous case-control study suggested that retired female workers in the highest manganese exposure model (tertile 3 of Mn-CEI) may be at higher risk of osteoporosis [14]. Besides, the European Food Safety Agency (EFSA) in 2013, judged that the available data to date are insufficient to establish an average requirement (Average Requirement, AR), as well as a reference intake for the population (Population Reference Intake, PRI) for Mn, and a tolerable upper intake level of manganese has not been established yet [15].…”

Section: Introductionmentioning

confidence: 98%

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Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study

Wang

Zhu²,

Long³

et al. 2022

PLoS ONE

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Purpose It has been reported that bone is the primary organ for manganese (Mn) accumulation, but the association between manganese and bone loss remains debatable. Therefore, this study aimed to evaluate the relationship between blood manganese and bone mineral density/bone mineral content (BMD/BMC) by using a representative sample from the National Health and Nutrition Examination Survey (NHANES). Methods A total of 9732 subjects over the age of 18 with available data were enrolled in this study. The relationship between blood manganese and BMD/BMC of the total body, spine and femoral regions was evaluated using multivariate linear regression models. Subgroup analyses were also performed. Results We observed a negative association between blood manganese and BMD/BMC in the femoral neck and total body in the fully adjusted model, especially femoral neck BMD in women aged 50–70 years. Conclusion In brief, people exposed to manganese should be aware of the increased risk of osteopenia or osteoporosis. Besides, due to the lack of available data, there are no definite values for the tolerable upper intake level (UL), average requirement (AR) and population reference intake (PRI) of manganese. The results of our study may provide some references for the establishment of AR, PRI and UL of Mn.

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HIF-1α upregulation exerts the antagonistic effect against angiogenesis inhibition in manganese deficiency-induced tibial dyschondroplasia of broiler chicks

Jin

Dong

et al. 2022

Vet Res Commun

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Manganese (Mn) is an essential microelement for broiler breeding and its de ciency causes tibial dyschondroplasia (TD). Tibial growth plate (TGP) development and metaphyseal vascularization are crucial for tibia growth in fast-growing broiler chickens, but their roles in Mn de ciency-induced TD in chicks remains unclear. This study was designed to clarify this issue. A total of 36 one-day-old broilers were divided into the control group and Mn-de ciency (Mn-D) group, which were fed with a standard diet (60 mg Mn/kg) and Mn de ciency diet (22 mg Mn/kg) for 42 days, respectively. TGP and proximal tibial metaphysis were collected to perform the related assays. First, Mn de ciency decreased the tibia length and TGP thickness in TD model. Mn de ciency reduced the number of blood vessels in proximal tibial metaphysis by histological analysis. Also, Mn de ciency decreased the mRNA and protein expression levels of vascular endothelial growth factor (VEGF) and macrophage migration inhibitory factor (MIF) in TGP. Moreover, up-regulation of hypoxia-inducible factor-1 alpha (HIF-1α) at both mRNA and protein levels was found in TGP of Mn-D group, suggesting the antagonistic role of HIF-1α against angiogenesis inhibition. Additionally, Mn de ciency enhanced the autophagy related 5 (ATG5) and microtubule associated protein 1 light chain 3 beta (LC3-II) expression levels, but decreased the SQSTM1 (p62) expression levels in TGP, suggesting autophagy activation in this process. Collectively, these data indicate that HIF-1α up-regulation and concurrent autophagy activation exert the protective effect against Mn de ciency-induced angiogenesis inhibition, which may provide a useful guidance to prevent TD in broilers.

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Association between long-term occupational manganese exposure and bone quality among retired workers

Cited by 20 publications

References 38 publications

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid

Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study

HIF-1α upregulation exerts the antagonistic effect against angiogenesis inhibition in manganese deficiency-induced tibial dyschondroplasia of broiler chicks

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