Association between low C-peptide and fragility fractures in postmenopausal women without diabetes

Ferro, Yvelise; Russo, Cristina; Russo, Diego; Gazzaruso, Carmine; Coppola, Adriana; Gallotti, Pietro; Zambianchi, V.; Fodaro, Mariangela; Romeo, Stefano; Galliera, Emanuela; Marazzi, Monica Gioia; Romanelli, Massimiliano Marco Corsi; Giannini, Sandro; Pujia, Arturo; Montalcini, Tiziana

doi:10.1007/s40618-017-0672-4

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…The management of these patients is, thus, largely empirical. Recently, two crosssectional studies suggested a pathogenic role of C-peptide deficiency in T1DM-related osteoporosis [21,22] and one in vitro study demonstrated that C-peptide might modulate the synthesis of key proteins for bone metabolism in human osteoblast-like cells [23].…”

Section: Introductionmentioning

confidence: 99%

Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats

et al. 2020

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C-peptide therapy protects against diabetic micro-and macrovascular damages and neuropatic complications. However, to date, the role of C-peptide in preventing diabetes-related bone loss has not been investigated. Our aim was to evaluate if C-peptide infusion improves bone quality in diabetic rats. Twenty-three male Wistar rats were randomly divided into three groups: normal control group; sham diabetic control group; diabetic plus C-peptide group. Diabetes was induced by streptozotocin injection and C-peptide was delivered subcutaneously for 6 weeks. We performed micro-CT and histological testing to assess several trabecular microarchitectural parameters. At the end, diabetic plus C-peptide rats had a higher serum C-peptide (p = 0.02) and calcium (p = 0.04) levels and tibia weight (p = 0.02) than the diabetic control group. The diabetic plus C-peptide group showed a higher trabecular thickness and cross-sectional thickness than the diabetic control group (p = 0.01 and p = 0.03). Both the normal control and diabetic plus C-peptide groups had more Runx-2 and PLIN1 positive cells in comparison with the diabetic control group (p = 0.045 and p = 0.034). Diabetic rats receiving C-peptide had higher quality of trabecular bone than diabetic rats not receiving this treatment. If confirmed, C-peptide could have a role in improving bone quality in diabetes. Keywords c-peptide • Bone microarchitectural parameters • Type 1 diabetes mellitus • Osteoporosis • Diabetic rat model Electronic supplementary material The online version of this article (

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Section: Introductionmentioning

confidence: 99%

Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats

et al. 2020

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“…Recently, two cross-sectional studies suggested a pathogenic role of C-peptide deficiency in T1DMrelated osteoporosis [26,27].…”

Section: Introductionmentioning

confidence: 99%

Effects of C-peptide replacement therapy on bone microarchitecture parameters in streptozotocin-diabetic rats

Maurotti

Russo

Musolino

et al. 2020

Preprint

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Pathological pathways involved in the development of diabetic complications are still unclear.Several studies suggested a pathogenic role of C-peptide deficiency in vascular and neuropathic complications. However, to date, the role of C-peptide on diabetes-related bone loss has not been investigated. The objective of this study was to test the effects of a 6-week regimen of rat C-peptide infusion on bone by combining micro-CT imaging with histological testing.Twenty-three, four-month-old male Wistar rats were randomly divided into three groups: Normal control group; Sham diabetic control group; Diabetic plus C-peptide group. Diabetes was induced by injection of streptozotocin. Rat C-peptide was delivered via subcutaneously osmopumps. We assessed several trabecular microarchitectural parameters and cellular and matrix proteins in bone tissue sections.At the end of the study, both the normal control and diabetic plus C-peptide groups had a higher tibia weight than the diabetic control group (p = 0.05 and p = 0.02, respectively). C-peptide levels significantly and positively correlated with the trabecular thickness (r= 0.45, p=0.08) and negatively with structure model index (r= -0.40, p=0.09). Furthermore, it positively correlated with one of the histological assessments (i.e. PLIN1 score; p=0.02). Micro-CT evaluation showed significant intergroup differences in trabecular thickness (p=0.02), trabecular space (p = 0.05) and cross-sectional thickness (p=0.05). Diabetic plus C-peptide group showed a higher trabecular thickness (p<0.001), cross-sectional thickness (p=0.03) and a lower trabecular space (p=0.05) than the normal control group. Both the normal control and diabetic plus C-peptide groups had more Runx-2 and PLIN1 positive cells in comparison to the diabetic control group (p = 0.045 and p = 0.034).For the first time we demonstrated that the diabetic rats receiving rat C-peptide had higher quality of trabecular bone, than diabetic rats not receiving it. C-peptide could have a role in the prevention of diabetes-related bone loss.

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Association of C-peptide level with bone mineral density in type 2 diabetes mellitus

Bai

Yang

et al. 2023

Osteoporos Int

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Association between low C-peptide and fragility fractures in postmenopausal women without diabetes

Cited by 6 publications

References 34 publications

Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats

Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats

Effects of C-peptide replacement therapy on bone microarchitecture parameters in streptozotocin-diabetic rats

Association of C-peptide level with bone mineral density in type 2 diabetes mellitus

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