Association between low lean mass and low bone mineral density in 653 women with hip fracture: does the definition of low lean mass matter?

Monaco, Marco Di; Castiglioni, Carlotta; Monaco, Roberto; Tappero, Rosa

doi:10.1007/s40520-017-0724-9

Cited by 19 publications

(10 citation statements)

References 31 publications

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“…Skeletal muscle is a significant but not the only component of lean body mass (LBM) or fat free mass (FFM). In a large number of clinical trials, lean mass (or FFM) is incorrectly referred to as muscle mass. We will discuss how the use of FFM as a surrogate for muscle mass has resulted in erroneous conclusions on the importance of skeletal muscle in development of late‐life dysfunction and risk of chronic disease.…”

Section: Introductionmentioning

confidence: 99%

D₃‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

Evans

Hellerstein

Orwoll

et al. 2019

J cachexia sarcopenia muscle

137

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Sarcopenia has been described as the age‐associated decrease in skeletal muscle mass. However, virtually every study of sarcopenia has measured lean body mass (LBM) or fat free mass (FFM) rather than muscle mass, specifically. In a number of published sarcopenia studies, LBM or FFM is referred to as muscle mass, leading to an incorrect assumption that measuring LBM or FFM is an accurate measure of muscle mass. As a result, the data on the effects of changes in LBM or FFM in older populations on outcomes such as functional capacity, disability, and risk of injurious falls have been inconsistent resulting in the conclusion that muscle mass is only weakly related to these outcomes. We review and describe the assumptions for the most commonly used measurements of body composition. Dual‐energy X‐ray absorptiometry (DXA) has become an increasingly common tool for the assessment of LBM or FFM and appendicular lean mass as a surrogate, but inaccurate, measurement of muscle mass. Other previously used methods (total body water, bioelectric impedance, and imaging) also have significant limitations. D 3 ‐Creatine (D 3 ‐Cr) dilution provides a direct and accurate measurement of creatine pool size and skeletal muscle mass. In a recent study in older men (MrOS cohort), D 3 ‐Cr muscle mass was associated with functional capacity and risk of injurious falls and disability, while assessments of LBM or appendicular lean mass by DXA were only weakly or not associated with these outcomes. Inaccurate measurements of muscle mass by DXA and other methods have led to inconsistent results and potentially erroneous conclusions about the importance of skeletal muscle mass in health and disease. The assessment of skeletal muscle mass using the D 3 ‐Cr dilution method in prospective cohort studies may reveal sarcopenia as a powerful risk factor for late life disability and chronic disease.

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Section: Introductionmentioning

confidence: 99%

D₃‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

Evans

Hellerstein

Orwoll

et al. 2019

J cachexia sarcopenia muscle

137

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show abstract

“…Our findings also seem to contradict the "bone-muscle unit" model, 23 suggesting that the crosstalk between bone and skeletal muscle may be impaired in late life. In a recent study by Di Monaco et al, 24 the association between sarcopenia and osteoporosis largely varied depending on the definition and index adopted to describe low LBM. The variability of the different indices of sarcopenia to capture concomitant disproportions in body compartments between groups needs to be further tested in larger cohorts.…”

Section: Discussionmentioning

confidence: 99%

Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia

Poggiogalle

Cherry

et al. 2019

Journal of the American Medical Directors Association

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“…У пациентов с нарушением обоих тканевых компонентов костно-мышечного аппарата, поступивших в реабилитационный центр с переломом бедра, диагностирована низкая МПК, которая положительно коррелирует с низкой безжировой массой конечностей (БМК). Как и ожидалось, у пациентов с переломом бедра распространены как саркопения, так и остеопороз [32][33][34]. В 2014 г. Ассоциация национальных институтов здравоохранения США (Foundation for the National Institutes of Health, FNIH) опубликовала новые пороговые значения клинически значимой низкой массы нежировых тканей [35].…”

Section: механическая среда и заживление дефектов субкритических размеровunclassified

Regenerative Rehabilitation for Bone Tissue Damage

Голота

Сергеевич²,

Makarenko

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

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The article is devoted to the analysis of the current state of regenerative and rehabilitative treatments in orthopedics, the possibilities of restoring of bone lost due to injuries or diseases. An overview of the main methods and approaches to enable effective regenerative and rehabilitation measures is given. The study of the molecular genetic basis of mechanotransduction and mechanotherapy will allow the identification of genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating of regeneration of bones. A special section is devoted to the study of the characteristics of cellular technologies in the treatment of injuries and diseases of these tissues. The focus of the article is on the choice of an individual approach, both when conducting basic scientific research and developing rehabilitation programs. All this will significantly improve patient outcomes.

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Association between low lean mass and low bone mineral density in 653 women with hip fracture: does the definition of low lean mass matter?

Abstract: The association between low aLM and low BMD in women with hip fracture dramatically depends on the adopted definition of low aLM. FNIH threshold for aLM (<15.02 kg) emerges as a useful tool to capture women with damage of the muscle-bone unit.

Cited by 19 publications

References 31 publications

D₃‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

D₃‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia

Regenerative Rehabilitation for Bone Tissue Damage

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Association between low lean mass and low bone mineral density in 653 women with hip fracture: does the definition of low lean mass matter?

Abstract: The association between low aLM and low BMD in women with hip fracture dramatically depends on the adopted definition of low aLM. FNIH threshold for aLM (<15.02 kg) emerges as a useful tool to capture women with damage of the muscle-bone unit.

Cited by 19 publications

References 31 publications

D3‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

D3‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia

Regenerative Rehabilitation for Bone Tissue Damage

Contact Info

Product

Resources

About

D₃‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass

D₃‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass