Association between Lower Intake of Minerals and Depressive Symptoms among Elderly Japanese Women but Not Men: Findings from Shika Study

Nguyen, Thao Thi Thu; Miyagi, Sakae; Tsujiguchi, Hiromasa; Kambayashi, Yasuhiro; Hara, Akinori; Nakamura, Haruki; Suzuki, Keita; Yamada, Yasuaki; Shimizu, Yukari; Nakamura, Hiroyuki

doi:10.3390/nu11020389

Cited by 46 publications

(43 citation statements)

References 59 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thi Thu Nguyen et al (2019) stated that a strong statistically inverse relation between depressive symptoms and serum Ca level (18). Also, the study by Miki et al2015 suggested that a higher dietary intake of Ca was associated with a lower prevalence of depressive symptoms (35).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies tackled the association of depression with CLD (15,16) while other studies search the relationship between trace elements and depression (17,18) but data about the association between depression in CLD and macroelements and TEs are limited. So the aim of our study is to detect the relationship between TEs, macro-minerals, and depression among older patients with CLD.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

et al. 2020

View full text Add to dashboard Cite

The prevalence of Chronic Liver Disease (CLD) is rising in the older population, older patients with CLD had a Poor Quality of Life (QOL) as they may present with emotional reactions reaching to depression with a deleterious effect on their life. Trace Elements (TEs) and macro-minerals levels may be varied in CLD. They are linked with depression. Objective: Our aim is to detect the association between TEs, macro-minerals, and depression among older patients with CLD. Materials and Methods: A cross-sectional study was conducted among 147 older patients with CLD. Depression was confirmed by the Patient Health Questionnaire (PHQ-9). Liver function tests, electrolytes and TEs (zinc (Zn) and copper (Cu)) were measured. Results: The prevalence of depression was 53.7%. Low serum sodium (Na) and calcium (Ca) levels were statistically significantly related to depression (P-value: 0.020 and 0.000 respectively) with lower serum Magnesium(Mg), serum Phosphorous(P) compared to higher serum Cu levels among depressed than nondepressed CLD, however no difference regarding serum Potassium (K) and Zn levels.By using univariate logistic regression, lower serum Na and Ca levels, malnutrition and diuretics were related to depression among CLD patients (P-value: 0.023, 0.001,0.000, 0.013 respectively). While by using multivariate logistic regression, malnutrition and low serum Ca levels were significantly associated with depression among older CLD patients (Pvalue: 0.001 and 0.014 respectively) Conclusion: Using diuretics and malnutrition are associated with depression through their effect on serum TEs and macro-minerals. Treating malnutrition and adjusting the dose of diuretics may decrease the risk of depression.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hostile male medical students seem to prefer salt (127) , and low dietary Na contributes to depression in Japanese men and marginally in American women, who may self-medicate with salt to improve their mood (39,101) . Other research has failed to relate the two or indicated cultural and dietary dependence, and yet other studies suggested salt may increase anxiety and even panic (127)(128)(129)(130)(131)(132) .…”

Section: Conditioning Salt Preference Through Exertion Mood Health mentioning

confidence: 99%

Salt need needs investigation

Leshem

2020

Br J Nutr

View full text Add to dashboard Cite

AbstractExpensive and extensive studies on the epidemiology of excessive Na intake and its pathology have been conducted over four decades. The resultant consensus that dietary Na is toxic, as well as the contention that it is less so, ignores the root cause of the attractiveness of salted food. The extant hypotheses are that most Na is infiltrated into our bodies via heavily salted industrialised food without our knowledge and that mere exposure early in life determines lifelong intake. However, these hypotheses are poorly evidenced and are meagre explanations for the comparable salt intake of people worldwide despite their markedly different diets. The love of salt begins at birth for some, vacillates in infancy, climaxes during adolescent growth, settles into separate patterns for men and women in adulthood and, with age, fades for some and persists for others. Salt adds flavour to food. It sustains and protects humans in exertion, may modulate their mood and contributes to their ailments. It may have as yet unknown benefits that may promote its delectability, and it generates controversy. An understanding of the predilection for salt should allow a more evidence-based and effective reduction of the health risks associated with Na surfeit and deficiency. The purpose of this brief review is to show the need for research into the determinants of salt intake by summarising the little we know.

show abstract

“…In addition, the hormone also inhibits the 5-hydroxytryptamine 3 (5-HT3) receptor, which is responsible for the serotonin uptake in the synaptic cleft, thereby reducing the stimulation of the target cell [12]. Antidepressants from the selective serotonin reuptake inhibitor (SSRIs) group have a similar effect.When analyzing the pathophysiology of depression symptoms, we should note the changes in concentrations of bioelements, as they may underlie the mechanisms leading to emotional disorders as well as clinical depression [13][14][15][16]. In suffering patients, magnesium supplementation has been used, as it affects several biochemical pathways in the brain responsible for apathy [17].…”

mentioning

confidence: 99%

“…When analyzing the pathophysiology of depression symptoms, we should note the changes in concentrations of bioelements, as they may underlie the mechanisms leading to emotional disorders as well as clinical depression [13][14][15][16]. In suffering patients, magnesium supplementation has been used, as it affects several biochemical pathways in the brain responsible for apathy [17].…”

mentioning

confidence: 99%

The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Aging Men

et al. 2020

View full text Add to dashboard Cite

Background and Objectives: Abnormal concentrations of bioelements (magnesium, manganese, chromium, copper, zinc) have been associated with physical and emotional dysfunctions, including depression. This association, however, has not been analyzed in testosterone deficiency syndrome (TDS) or patients with depressiveness, i.e., when individual symptoms do not form the picture of a full-syndrome depressive disorder. This study aimed to assess the relationship between concentrations of selected bioelements and the incidence of depressive symptoms in men aged 50 years and older with a concurrent testosterone deficiency syndrome. Material and Methods: Blood samples were taken from 314 men; the mean age of the population was 61.36 ± 6.38 years. Spectrophotometric method for biochemical analysis of magnesium (Mg), manganese (Mn), chromium (Cr), copper (Cu), and zinc (Zn) was used. The diagnosis of testosterone deficiency syndrome (TDS) was based on the total testosterone (TT), free testosterone (FT), estradiol (E2), and dehydroepiandrosterone sulfate (DHEAS) levels by ELISA. Each participant completed the Androgen Deficiency in Aging Male (ADAM) questionnaire, as well as the Beck Depression Inventory (BDI-Ia) measuring the severity of depressive symptoms. Results: Emotional disturbances manifested as depressive symptoms were diagnosed in 28.7% of all participants and testosterone deficiency syndrome in 49.3%. In the TDS group, the analysis showed a significant correlation between the level of manganese (R = 0.225, p = 0.005) and chromium (R = 0.185, p = 0.021) with the incidence of depression. Conclusions: The results of our study demonstrated a relationship between manganese and chromium concentrations with the incidence of depression in men aged 50 years and older with a concurrent testosterone deficiency syndrome. This may indicate that there is a correlation between these bioelements, as well as emotional disorders manifested as depressive symptoms in aging men with a diagnosed testosterone deficiency.

show abstract

Association between Lower Intake of Minerals and Depressive Symptoms among Elderly Japanese Women but Not Men: Findings from Shika Study

Cited by 46 publications

References 59 publications

The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

Salt need needs investigation

The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Aging Men

Contact Info

Product

Resources

About