Association between &lt;i&gt;Helicobacter pylori&lt;/i&gt; infection and platelet count in mice

Fukuda, Teruko; Asou, Eri; Nogi, Kimiko; Yasuda, Masahiko; Goto, Kazuo

doi:10.1538/expanim.18-0004

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Thus, this experimental study incriminated the variability of the major histocompatibility complex as the most-likely factor responsible for thrombocytopenia and not the antibodies directed against H pylori. [ 33 ] Nevertheless, there are few data regarding a possible association between H pylori and thrombocytopenia in children. These studies involved a small number of patients, and described a partial or significant increase in platelet count only in selected cases after eradication of H pylori .…”

Section: Discussionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori ( H pylori ) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We performed a prospective, case–control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case. Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1— H pylori -induced gastritis (31 patients) and group 2—non- H pylori- induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis ( P < .01). No significant difference was found between either of the study groups and control group in terms of platelets, mean platelet volume, NLR and PLR ( P > .05). However, significantly higher values of lymphocytes were associated with non- H pylori -induced gastritis ( P < .01). Comparison of the two study groups did not reflect any significant differences in terms of hematological parameters. When assessing these constants in relation to gastritis severity, severe gastritis led to a compelling decrease in hemoglobin (Hb) and hematocrit (Htc) levels. The comparison of parameters between severe, moderate, and mild gastritis did not reveal any significant results. Childhood and adolescent gastritis does not produce a significant effect upon platelet counts, their mean volume, PLR or NLR, according to our study. An important increase in lymphocyte count might predict non- H pylori pediatric gastritis. Moreover, severe gastritis might result in an important decrease in Hb and Htc levels.

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Section: Discussionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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“…Another experiment was conducted on 9 mice type BALB, and after two months of infection of H. pylori, a decrease of platelet counts because of the interaction of the anti-H. pylori with the antigens which on the surface of the platelets (Fukuda et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

The effect of the presence of Helicobacter pylori bacteria to all kinds of blood components

Lateef¹

2022

CBERJ

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Helicobacter pylori is a gram-negative, micro-aerobic, spiral-shaped bacteria which is considered one of the main factors that lead to stomach disorders such as gastric atrophy, stomach cancer, chronic gastritis, and peptic ulcers. The present study was carried out in Nineveh Governorate, Iraq. The sample of the study included 325 participants. After conducting a series of tests to detect whether H. pylori infection is positive among the participants, it has been shown that the number of infected participants were150 (48 males and 102 females), then complete Blood Counts test have been done in order to investigate the relationship between the Component Blood Count and the infection of H. pylori.Based on the results, it is concluded that H. pylori infection is more prevalent in females. Also, the percentage of infection decreases in ages over 60 years and in children less than 15 years. Moreover, it is revealed that the incidence of H. pylori infection increases in people with blood type A. Finally, the study doesn't show any effect of smoking on the increased risk of infection with H. pylori. In this study, the infected patients with H. pylori recorded an increase in WBCs equal to 24%, while lymphocyte counts didn't record any changes, RBCs were increased by 12%, some infected patients had fluctuations of increase and decrease in the level of Hb, the figures were between 8% and 24%, respectively, the increase in the platelet count was 12%, and the decrease was 4%. Hence, there are significant differences in the relationship between infection with H. pylori and other factors such as; gender, age, WBCs, lymphocyte counts, RBCs, Hb, and platelet counts in the infected group at P ≤ 0.05.

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“…CagA is an immunogenic protein that stimulates the production of antibodies. Because of the molecular mimicry between CagA and GP IIb/IIIa on platelets, it is possible that antibodies against CagA cause increased destruction of antibody-coated platelets by the reticuloendothelial system in patients with chronic ITP [ 35 , 36 ]. Another aspect of this association is mediated by the vacuolating cytotoxin A gene (VacA), which is another important virulence factor of H. pylori .…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter Pylori eradication on patients with ITP: a meta-analysis of studies conducted in the Middle East

et al. 2021

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Immune thrombocytopenia (ITP) is a bleeding disorder. Helicobacter pylori is a Gram-negative bacterium that is presumed to be associated with ITP and therapeutic response of patients. To evaluate the effect of H. pylori eradication on the platelet count of patients with ITP. To this end, we analyzed studies conducted on the association between H. pylori infection and response to therapy in patients with ITP in Western Asia, with a particular focus on the Middle East region. A systematic search of databases (PubMed/Medline, ISI Web of Science, Cochrane Central) and Google Scholar search engine results was conducted up until January 2020. The keywords included in the search were Helicobacter pylori and/or H. pylori, ITP and/or immune thrombocytopenia. Seven studies comprising a total of 228 H. pyloriinfected patients (193 with successful eradication) were included in this study. The association between H. pylori eradication and ITP was expressed as odds ratios (ORs) and 95% confidence intervals (CI). The findings showed that patients who received eradication treatment for H. pylori infection had significantly higher ORs (OR, 8.83; 95% CI, 2.03-38.35; P=0.004) than those in the non-eradicated group. Our results indicate a significant therapeutic effect of H. pylori eradication on the platelet count of patients with chronic ITP. Given the inherent limitations of this study, including the small number of patients, further studies with more patients are recommended.

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Association between <i>Helicobacter pylori</i> infection and platelet count in mice

Cited by 5 publications

References 23 publications

Pediatric gastritis and its impact on hematologic parameters

Pediatric gastritis and its impact on hematologic parameters

The effect of the presence of Helicobacter pylori bacteria to all kinds of blood components

Effect of Helicobacter Pylori eradication on patients with ITP: a meta-analysis of studies conducted in the Middle East

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