Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer

Ding, Ding; Stokes, William A.; Eguchi, Megan; Hararah, Mohammad K.; Sumner, Whitney; Amini, Arya; Goddard, Julie; Somerset, Hilary; Bradley, Cathy J.; McDermott, Jessica D.; Raben, David; Karam, Sana D.

doi:10.1001/jamaoto.2018.2974

Cited by 67 publications

(59 citation statements)

References 34 publications

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“…Lymph node ratio is an established risk factor for recurrence and survival in oral cavity malignancies. 6 In our study there was no difference in the lymph node ratio between the intermediate and deep tumour groups.…”

Section: Discussioncontrasting

confidence: 51%

A prospective study to evaluate the impact and independency of depth of invasion in comparison with other clinicopathologic prognostic variables in oral cavity malignancy

Shanmugam

Govindasamy

Raja

2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Depth of invasion is included in the staging of oral cavity malignancies in the recent 8 th edition of American Joint Committee on Cancer or tumour, node and metastasis staging system. This study analyses the impact of diffuse optical imaging (DOI) on incidence of lymph node involvement, stage migration, postoperative margin and independency. Methods: Postoperative HPE of fifty patients with oral cavity malignancy operated in our institute from January 2018 were collected. Depth of invasion and other pathological parameters were documented. DOI divided into three groups and statistical analysis done. Results: No lymph node metastasis is found in superficial tumours, 43% of intermediate thickness and 76% of deep tumours had lymph node involvement. Positive margin is seen only in patients with tumour DOI more than 0.5 cm, more than 50% of deep tumours had close margins while 75% of superficial tumours had adequate margin. Out of the 24 T3 tumours in this study 13 were upstaged due to inclusion of DOI, which would have been T2 according to the previous staging system. There is 54.1% (13 out of 24) upstaging in T3 tumours (T2 to T3), 23% (3 out of 13) in T2 (T1 to T2). There is no significant correlation between DOI and anatomical site, tumour size, tumour thickness, lymphovascular invasion and grade. Conclusions: Depth of invasion in oral cavity malignancies impacts adversely lymph node metastasis and margin status. It is an independent prognostic factor in oral cavity malignancy.

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Section: Discussioncontrasting

confidence: 51%

A prospective study to evaluate the impact and independency of depth of invasion in comparison with other clinicopathologic prognostic variables in oral cavity malignancy

Shanmugam

Govindasamy

Raja

2020

Int J Otorhinolaryngol Head Neck Surg

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“…Although surgery, chemotherapy, and radiotherapy could cure the majority of cases of early‐stage OSCC, the outcome of most patients with advanced‐stage OSCC has not improved during the last three decades. Cancer metastasis, neoplasm recurrence, and drug resistance are the foremost confounders accountable for the poor 5‐year survival rate that usually <50% . Therefore, as an alternative strategy for advanced stage OSCC treatment, cancer research target has been directed at interfering with key mediators of metastasis in the past few decades.…”

Section: Introductionmentioning

confidence: 99%

CCL2 promotes cell migration by inducing epithelial‐mesenchymal transition in oral squamous cell carcinoma

Ling

Yang

Chen

et al. 2019

J Oral Pathology Medicine

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Background Although a few studies suggested that the chemokine CCL2 might be involved in the development of oral squamous cell carcinoma (OSCC), the exact mechanism remains unclear. In this study, we aimed to determine the resource of CCL2 in lesions and explored a potential mechanism that CCL2 promotes tumor progression. The study was an effort to provide new insights into the pathological role of CCL2 in OSCC. Methods Specimens of OSCC and normal oral mucosa were stained using immunohistochemistry (IHC) to assess the CCL2 expression. Enzyme‐linked immunosorbent assay (ELISA) was used to detect the difference of CCL2 between OSCC and normal oral mucosa cell lines. In addition, we treated OSCC cells with exogenous rCCL2 combined with or without CCL2 neutralizing antibody and then determined the changes of in epithelial‐mesenchymal transition (EMT) markers and cell migration capacity using immunofluorescence, Western blotting, transwell migration, and wound healing assays. Results We have found that CCL2 expression was upregulated significantly in both lesions and cell culture supernatant of OSCC compared with controls. IHC staining demonstrated that CCL2 expression was primarily located in the cytoplasm and cell membrane of cells. We have also found that rCCL2 could effectively induce EMT through upregulating Snail in OSCC cells, which was demonstrated by the decrease of E‐cadherin and the increase of vimentin. In addition, we have found that CCL2 neutralizing antibody could block EMT induced by CCL2 in OSCC. Conclusions CCL2 secreted by cancer cells can promote cell migration by inducing EMT via paracrine or autocrine in OSCC.

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“…20 Secondly, the decreased lymphocyte count plays important roles in inflammatory reaction to tumor. 8 This can explain why increased NLR acts as an independent prognostic factor. There were evidence that showed an early diminution in NLR may be associated with more favorable outcomes and higher response rates, whereas an increase in NLR in the first weeks of treatment had the opposite effect.…”

Section: Discussionmentioning

confidence: 99%

“…There were evidence that showed an early diminution in NLR may be associated with more favorable outcomes and higher response rates, whereas an increase in NLR in the first weeks of treatment had the opposite effect. 8 Thirdly, platelets direct tumor cell growth, vascular invasion, hematogenous dissemination, immune system evasion and establishment of a metastatic niche. Fourthly, nutrition parameters must be taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

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<p>Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma</p>

Ye¹,

Liao²,

Jiang³

et al. 2020

CMAR

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Background: Peripheral blood inflammation factor neutrophil-lymphocyte ratio (NLR), platelet count (PLT) and nutritional factor serum albumin (ALB) have been proposed as prognostic markers of head and neck squamous carcinoma cancer (HNSCC) in recent years. In the current study, nomogram predict models based on pre-treatment hematological parameters and a modified risk-stratified score system have been built. Methods: A total of 197 patients with oropharyngeal, hypopharyngeal and laryngeal cancers receiving multimodality treatment between 2012 and 2014 were included. The pre-treatment ALB, neutrophil, lymphocyte and platelet count (PLT) were detected. Cancer-specific survival and locoregional recurrence (LRC) by 5 years' follow-up in the cases were obtained. To integrate clinical characteristics, we propose a modified risk-stratified score system. Kaplan-Meier method, proportional hazards COX model, logistic models were used to establish nomograms within external validation. Results: Five-year LRC was decreased (p=0.004) for 140 patients with pre-treatment NLR <2.77. Five-year LRC and 5-year cancer-specific survival were decreased (p=0.031, p=0.021) with pre-treatment PLT ≥248×10 9 /L. Comparison of univariate parametric models demonstrated that pre-treatment NLR evaluation and PLT>248×10 9 /L were better among tested models. On Bayesian information criteria (BIC) analysis, the optimal prognostic model was then used to develop nomograms predicting 3-and 5-year LRC. The external validation of this predictive model was confirmed in 57 patients from another hospital. Conclusion: Pre-treatment NLR elevation and PLT>248×10 9 /L are promising predictors of prognosis in patients with operable HNSCC. Nomograms based on the pre-treatment hematological markers and modified risk-stratified score system provide distinct risk stratifications. There results provided the feasibility of anti-inflammatory and antiplatelet treatments for HNSCC patients.

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Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer

Cited by 67 publications

References 34 publications

A prospective study to evaluate the impact and independency of depth of invasion in comparison with other clinicopathologic prognostic variables in oral cavity malignancy

A prospective study to evaluate the impact and independency of depth of invasion in comparison with other clinicopathologic prognostic variables in oral cavity malignancy

CCL2 promotes cell migration by inducing epithelial‐mesenchymal transition in oral squamous cell carcinoma

<p>Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma</p>

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