2023
DOI: 10.1101/2023.11.21.23298814
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Association Between Major Depressive Disorder and the Development of Cerebral Small Vessel Disease: A Mendelian Randomization Study

Ting Lu,
Lijun Luo,
Jie Yang
et al.

Abstract: BackgroundAlthough observational studies indicate a complex, bidirectional association between major depressive disorder (MDD) and cerebral small vessel disease (CSVD), the results are frequently inconsistent. This study investigated the potential correlation of MDD with both CSVD clinical outcomes and imaging markers, utilizing a bidirectional Mendelian randomization (MR) study design.MethodsInstrumental variables for both MDD and CSVD were extracted from the latest or most extensive genome-wide association s… Show more

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