Association between major depressive symptoms in heart failure and impaired regional cerebral blood flow in the medial temporal region: a study using  99m Tc-HMPAO single photon emission computerized tomography (SPECT)

Alves, Tania C. T. Ferraz; Rays, Jairo; Fráguas, Renério; Wajngarten, Maurı́cio; Telles, Renata M.S.; Duran, Fábio Luís de Souza; Meneghetti, José Cláudio; Robilotta, Cecil Chow; Prando, Silvana; Castro, Cláudio Campi de; Buchpiguel, Carlos Alberto; Busatto, Geraldo F.

doi:10.1017/s0033291706007148

Cited by 33 publications

(31 citation statements)

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“…Cerebral perfusion also likely plays a critical role, as hypoperfusion is commonly theorized to underlie cognitive deficits in HF patients (Jefferson, et al, 2007; Jefferson, Poppas, Paul, & Cohen, 2007) and this deficiency may be alleviated through improved physical fitness (Stanek, et al, 2011; Rogers, Meyer, & Mortel, 1990). Depressed HF patients appear to be a greater risk for reduced cerebral perfusion (Alves, et al, 2006) and prospective studies should examine whether exercise interventions in HF patients with depression improves cognitive function.…”

Section: Discussionmentioning

confidence: 99%

“…Recent work in this population links increased depressive symptomatology with deficits in attention, executive function, psychomotor speed, and language (Garcia, et al, 2011). Pathophysiological changes (i.e., reduced cerebral blood flow) have also been noted among HF patients with depression relative to their non-depressed counterparts (Alves, et al, 2006). …”

Section: Introductionmentioning

confidence: 99%

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Depressive Symptomatology, Exercise Adherence, and Fitness Are Associated With Reduced Cognitive Performance in Heart Failure

et al. 2013

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Objectives Depression is common in heart failure (HF) and associated with reduced cognitive function. The current study used Structrual Equation Modeling to examine whether depression adversely impacts cognitive function in HF through its adverse affects on exercise adherence and cardiovascular fitness. Methods 158 HF patients completed neuropsychological testing, physical fitness test, Beck Depression Inventory-II (BDI-II), and measures assessing exercise adherence, and physical exertion. Results The model demonstrated excellent model fit and increased scores on the BDI-II negatively affected exercise adherence and cardiovascular fitness. There was a strong inverse association between cardiovascular fitness and cognitive function. Sobel test showed a significant indirect pathway between the BDI-II and cognitive function through cardiovascular fitness. Discussion This study suggests depression in HF may adversely impact cognitive function through reduced cardiovascular fitness. Prospective studies are needed to determine whether treatment of depression can lead to better lifestyle behaviors and ultimately improve neurocognitive outcomes in HF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Depressive Symptomatology, Exercise Adherence, and Fitness Are Associated With Reduced Cognitive Performance in Heart Failure

et al. 2013

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“…Diversos aspectos associados à cardiopatia podem contribuir para que a depressão nesses pacientes possua características diversas daquela encontrada em pacientes sem cardiopatia. As anormalidades vasculares parecem estar subjacente ao desenvolvimento de transtornos de humor de início tardio 35,[37][38][39] .…”

Section: Cardiopatia Como Fator De Risco Para Depressãounclassified

“…Sujeitos com ICC apresentam diminuição da circulação sanguínea cerebral global e regional 39,40 , envolvendo regiões límbicas e paralímbicas na depressão na IC 39 .…”

Section: Cardiopatia Como Fator De Risco Para Depressãounclassified

Depressão e infarto agudo do miocárdio

Alves¹,

Fráguas²,

Wajngarten³

2009

Rev. psiquiatr. clín.

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ResumoA associação entre transtorno depressivo maior e doenças cardiovasculares, em particular infarto agudo do miocár-dio, é frequente, levando a pior prognóstico tanto da depressão como da doença cardiovascular, com maiores taxas de reinfarto e maior morbidade e mortalidade. Os autores discutem as evidências na literatura que demonstram essa associação entre infarto agudo do miocárdio e quadros depressivos, com enfoque nos avanços em fisiopatologia e terapêutica psiquiátrica. Vários estudos têm mostrado que o tratamento da depressão associada a quadros cardíacos é eficaz, melhora a qualidade de vida e pode ser feito com segurança. Embora o tratamento da depressão tenha sido associado à melhora de alguns parâmetros cardiovasculares, ainda não existem, entretanto, evidências de associação entre tratamento da depressão e melhora da morbidade e mortalidade cardiovascular.Alves TCTF, et al. / Rev Psiq Clín. 2009;36(3):88-92 Palavras-chave: Depressão, infarto agudo do miocárdio, fisiopatologia, prognóstico. AbstractThe association between major depressive disorder and cardiovascular diseases, particularly myocardial infarction, is frequently observed, leading to worse prognosis both on the depressive disorder as well as cardiovascular disease, with increased rates of re-infarction and both morbidity and mortality. The authors review and discuss the evidence in the literature that supports the relationship between depressive disorder and cardiovascular disease, with focus on the advances on the physiopathology and the psychiatric management. Various studies have shown that treatment of depression is efficacious, improves quality of life and can be safely conducted. Although, treatment of depression has been associated with improvement on some cardiovascular parameters, there is no evidence so far that treatment of depression is associated with decrease of cardiovascular morbidity and mortality.Alves TCTF, et al. / Rev Psiq Clín. 2009;36(3):88-92

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“…This may be due to decreased cerebral blood flow or the accumulative of central nervous system small vessel ischemic disease. Demonstration of decreased medial temporal blood flow associated with depressive symptoms is an alternative explanation [39].…”

Section: Chf Symptoms and Functional Abilitymentioning

confidence: 99%

Symptom perception in CHF: (why mind matters)

Skotzko

2007

Heart Fail Rev

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Symptoms utilized in the clinical care of heart failure as markers of disease severity include, dyspnea, insomnia, low energy, fatigue, poor appetite, and diminished memory. This is despite the fact that physiologic variables such as cardiac ejection fraction and oxygen consumption do not accurately predict functional state in individuals with congestive heart failure (CHF). Distress (anxiety and depression) may amplify symptom complaints without associated physiologic aberration. Personality traits and psychiatric illness, such as mood, anxiety, and psychotic illnesses may also alter perception of somatic symptoms that are associated with this chronic illness. The impact of distress and its treatment on functional performance and CHF symptom reporting deserve additional attention. The need to screen for distress in all with serious symptomatic heart failure is certain.

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Association between major depressive symptoms in heart failure and impaired regional cerebral blood flow in the medial temporal region: a study using 99m Tc-HMPAO single photon emission computerized tomography (SPECT)

Abstract: These findings are consistent with the notion that the medial temporal region is vulnerable to brain perfusion deficits associated with HF, and provide evidence that such functional deficits may be specifically implicated in the pathophysiology of MDD associated with HF.

Cited by 33 publications

References 40 publications

Depressive Symptomatology, Exercise Adherence, and Fitness Are Associated With Reduced Cognitive Performance in Heart Failure

Depressive Symptomatology, Exercise Adherence, and Fitness Are Associated With Reduced Cognitive Performance in Heart Failure

Depressão e infarto agudo do miocárdio

Symptom perception in CHF: (why mind matters)

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