Association between maternal depression and neonatal outcomes: Evidence from a survey of nationally representative longitudinal studies

Abstract

Background and aimsMaternal depression before and after delivery has dramatically increased in China. Therefore, this study aimed to examine the association between antepartum and postpartum depression and neonatal outcomes.DesignA population-based retrospective cohort study.SettingChina.ParticipantsData were obtained from China Family Panel Studies (CFPS). Different mother-child/infant samples were included in this study. Mother in CFPS2012 and CFPS2016 were linked with 1–2-year-old children in CFPS2014 and CFPS2018, respectively. Besides, and mothers in CFPS2012, CFPS2016, and CFPS2018 were linked with 0–1-year-old infants in CFPS2012, CFPS2016, and CFPS2018, respectively.MethodsMaternal depression was measured using the Center for Epidemiologic Studies Depression Scale. The neonatal outcomes included duration of gestational days, preterm birth, birth weight, birth weight z-score, weight, weight z-score, illness in the past month, and hospitalization in the past year. Propensity score matching was used to balance maternal, family, and infant/child characteristics between the maternal depression and non-maternal depression groups.ResultsMultivariable regression analysis of matched samples estimated that antepartum depression was associated with a shorter duration of gestation by 3.99 days (95% confidence interval [CI] = −7.21, −0.78). The association between antepartum depression and preterm birth, birth weight and birth weight z-score were not statistically significant. Postpartum depression was associated with more episodes of illness in the last month by 0.23 times (95% CI = 0.11, 0.36) and a higher odd of hospitalization in the previous year (OR = 1.59, 95% CI = 1.15, 2.20). The association between postpartum depression and weight or the weight z-score was not significant.ConclusionMaternal depression appears to be associated with worse neonatal outcomes.

Trajectories of antepartum depressive symptoms and birthweight: a multicenter and prospective cohort study

“…18 Previous findings regarding the relationship between antepartum depression and LBW were inconsistent. Some studies [12][13][14][15] identified a significant risk of LBW due to antepartum depression, while others 19,20 found no association. Most of these studies had crosssectional designs and measured the symptoms of antepartum depression only once during pregnancy rather than measuring the trajectories of depressive symptoms during gestation.…”

Comparative analysis of the use of selective serotonin reuptake inhibitors during pregnancy and the postpartum period. Safety of sertraline

“…Послеродовой психоз и тяжелая послеродовая депрессия ассоциируются с высоким риском осложнений, включая суицид, инфантицид и отказ от грудного вскармливания, полезного для здоровья матери и ребенка и способствующего установлению тесного контакта между ними на всю последующую жизнь [10,11]. Послеродовую депрессию переносят до 14% женщин, частота послеродовых психозов составляет один-два случая на 1000 родов [10].…”