Association between maternal iron supplementation and newborn birth weight: a quantile regression analysis

Shi, Guoshuai; Zhang, Zhuo; Ma, Lu; Zhang, Binyan; Dang, Shaonong; Yan, Hong

doi:10.1186/s13052-021-01084-7

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Our finding was consistent with some previous studies. A large cross-sectional study in China showed that iron supplementation was positively associated with birth weight after controlling some potential confounders 14 . National representative data from India also found that iron supplementation during pregnancy was inversely associated with LBW after adjusting for socioeconomic status.…”

Section: Discussionmentioning

confidence: 99%

Iron intake during pregnancy reduces low birth weight: A propensity score analysis

Saptarini,

Suparmi,

Rizkianti

2023

Sri Lanka J Child Health

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Background: Low birth weight (LBW) remains a significant public health problem. As nutritional problems, including anaemia, can cause LBW, iron supplementation is needed during pregnancy. Objectives: To assess the impact of iron supplementation during pregnancy on birth weight in Indonesia using data from the 2017 Indonesia Demographic Health Survey (IDHS). Method: Birth weight was categorized into two groups, LBW (<2500g) and normal birth weight (2500g or more). Iron supplementation was constructed into two groups, mothers who did not take or whose intake was less than 90 tablets during pregnancy and mothers who took ≥90 tablets during pregnancy. A sample of 10,518 children born within five years was matched using propensity scores. We used binary logistic regression and adjusted for 12 possible confounders after matching the data. Then, we performed logistic regression to assess the relationship between iron intake during pregnancy and birth weight. We built multistage multivariate logistic regression models using the backward elimination technique. We adjusted the model with some confounding factors, including socioeconomic and community-level factors, maternal and child characteristics, and maternal and child health services. Results: After adjusting for potential confounders, this study found that iron supplementation during pregnancy significantly reduced LBW (AOR: 0.75; 95% CI: 0.64 to 0.88). Conclusions: This study found that iron supplementation during pregnancy significantly reduced LBW Sri Lanka Journal of Child Health, 2023; 52(2): 136-141

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Section: Discussionmentioning

confidence: 99%

Iron intake during pregnancy reduces low birth weight: A propensity score analysis

Saptarini,

Suparmi,

Rizkianti

2023

Sri Lanka J Child Health

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“…In the present study, no association was found between Fe supplementation and neonatal morphometric parameters. However, Shi et al [51], in their study of women and newborns from singleton pregnancies, reported that Fe supplementation during pregnancy had an effect on increasing the birth weight of newborns, particularly in women with anemia. However, it is important that the supplementation is individually tailored, as the excessive intake of Fe may have negative effects on fetal development.…”

Section: Iron Concentration In Afterbirthmentioning

confidence: 98%

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies

et al. 2023

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The aim of this study was to evaluate the intensity of oxidative stress by measuring the concentrations of lipid peroxidation products (LPO) in fetal membrane, umbilical cord, and placenta samples obtained from women with multiple pregnancies. Additionally, the effectiveness of protection against oxidative stress was assessed by measuring the activity of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR). Due to the role of iron (Fe), copper (Cu), and zinc (Zn) as cofactors for antioxidant enzymes, the concentrations of these elements were also analyzed in the studied afterbirths. The obtained data were compared with newborn parameters, selected environmental factors, and the health status of women during pregnancy to determine the relationship between oxidative stress and the health of women and their offspring during pregnancy. The study involved women (n = 22) with multiple pregnancies and their newborns (n = 45). The Fe, Zn, and Cu levels in the placenta, umbilical cord, and fetal membrane were determined using inductively coupled plasma atomic emission spectroscopy (ICP-OES) using an ICAP 7400 Duo system. Commercial assays were used to determine SOD, GPx, GR, CAT, and LPO activity levels. The determinations were made spectrophotometrically. The present study also investigated the relationships between trace element concentrations in fetal membrane, placenta, and umbilical cord samples and various maternal and infant parameters in women. Notably, a strong positive correlation was observed between Cu and Zn concentrations in the fetal membrane (p = 0.66) and between Zn and Fe concentrations in the placenta (p = 0.61). The fetal membrane Zn concentration exhibited a negative correlation with shoulder width (p = −0.35), while the placenta Cu concentration was positively correlated with placenta weight (p = 0.46) and shoulder width (p = 0.36). The umbilical cord Cu level was positively correlated with head circumference (p = 0.36) and birth weight (p = 0.35), while the placenta Fe concentration was positively correlated with placenta weight (p = 0.33). Furthermore, correlations were determined between the parameters of antioxidative stress (GPx, GR, CAT, SOD) and oxidative stress (LPO) and the parameters of infants and maternal characteristics. A negative correlation was observed between Fe and LPO product concentrations in the fetal membrane (p = −0.50) and placenta (p = −0.58), while the Cu concentration positively correlated with SOD activity in the umbilical cord (p = 0.55). Given that multiple pregnancies are associated with various complications, such as preterm birth, gestational hypertension, gestational diabetes, and placental and umbilical cord abnormalities, research in this area is crucial for preventing obstetric failures. Our results could serve as comparative data for future studies. However, we advise caution when interpreting our results, despite achieving statistical significance.

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“…In a meta-analysis of 48 randomized controlled trials (RCTs) and 44 cohorts, it was found that prenatal iron supplementation was associated with higher birth weight and a lower risk of low birth weight (LBW) compared to no supplementation [6]. Several studies have found positive associations between iron supplementation [13], dietary iron intake [14][15][16], and iron concentration in blood [17], cord blood [18], and placenta [8], and neonatal anthropometric indicators such as body length [8,19,20], chest circumference [21], and head circumference [7,18]. Two systematic reviews [22,23] did not find any significant associations between iron supplementation (mostly combined with folic acid) and anthropometric indicators in infants, children, and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Associations of maternal serum concentration of iron-related indicators with birth outcomes in Chinese: a pilot prospective cohort study

Chen,

Li,

Zhou

et al. 2024

Ital J Pediatr

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Background Previous studies of maternal iron and birth outcomes have been limited to single indicators that do not reflect the comprehensive relationship with birth outcomes. We aimed to investigate the relationship between maternal iron metabolism and neonatal anthropometric indicators using comprehensive iron-related indicators. Methods A total of 914 Chinese mother-child dyads were enrolled in this prospective study. Subjects’ blood samples were collected at ≤ 14 weeks of gestation. Serum concentrations of iron-related indicators were measured by enzyme-linked immunosorbent assay (ELISA). Femur length was measured by B-ultrasound nearest delivery. Neonatal anthropometric indicators were collected from medical records. Results After adjustment for potential covariates, higher iron (per one standard deviation, SD increase) was detrimentally associated with − 0.22 mm lower femur length, whereas higher transferrin (per one SD increase) was associated with 0.20 mm higher femur length. Compared with normal subjects (10th-90th percentiles), subjects with extremely high (> 90th percentile) iron concentration were detrimentally associated with lower femur length, birth weight, and chest circumference, and a higher risk of low birth weight, LBW (HR: 3.92, 95%CI: 1.28, 12.0). Subjects with high concentration of soluble transferrin receptor, sTFR and transferrin (> 90th percentile) were associated with higher femur length. Subjects with low concentration of iron and ferritin concentrations (< 10th percentile) were associated with a higher risk of LBW (HR: 4.10, 95%CI: 1.17, 14.3) and macrosomia (HR: 2.79, 95%CI: 1.06, 7.35), respectively. Conclusions Maternal iron overload in early pregnancy may be detrimentally associated with neonatal anthropometric indicators and adverse birth outcomes.

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Association between maternal iron supplementation and newborn birth weight: a quantile regression analysis

Cited by 9 publications

References 36 publications

Iron intake during pregnancy reduces low birth weight: A propensity score analysis

Iron intake during pregnancy reduces low birth weight: A propensity score analysis

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies

Associations of maternal serum concentration of iron-related indicators with birth outcomes in Chinese: a pilot prospective cohort study

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