Association between maternal lipid levels during pregnancy and delivery of small for gestational age: A systematic review and meta-analysis

Wang, Yuan; Chen, Zhifang; Zhang, Feng

doi:10.3389/fped.2022.934505

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…The aforementioned studies provide support for our ndings regarding the causal associations between genetically predicted rheumatoid arthritis and gestational hypertension, pre-eclampsia, fetal growth restriction, and preterm delivery. There was certainly a good deal of evidence that rheumatoid arthritis was the risk factor for small for gestational age infants (5,13,32) . However, due to the limited number of GWAS studies, we have been unable to nd a suitable database.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Adverse Pregnancy Outcomes: A Bidirectional Two-Sample Mendelian Randomization Study

Chang,

Zhao,

Liu

et al. 2024

Preprint

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Background There is growing evidence of bidirectional associations between rheumatoid arthritis and adverse pregnancy outcomes (APOs) in observational studies, but little is known about the causal direction of these associations. Therefore, we explored the potential causal relationships between rheumatoid arthritis and APOs using a bidirectional two-sample Mendelian randomization (MR). Methods We conducted a bidirectional two-sample Mendelian randomization analysis using available summary statistics from released genome-wide association studies. Summary statistics for instrument–outcome associations were retrieved from two separate databases for rheumatoid arthritis and adverse pregnancy outcomes, respectively. The inverse-variance weighted method was used as the primary MR analysis. MR-Egger, MR pleiotropy residual sum and outlier (MR-PRESSO), and Cochran Q statistic method were implemented as sensitivity analyses approach to ensure the robustness of the results. Results Our study showed that a higher risk of genetically predicted rheumatoid arthritis was associated with gestational hypertension (OR: 1.04, 95%CI: 1.02–1.06), pre-eclampsia (OR: 1.06, 95%CI: 1.01–1.11), fetal growth restriction (OR: 1.08, 95%CI: 1.04–1.12), preterm delivery (OR:1.04, 95%CI: 1.01–1.07). Furthermore, we found no evidence that APOs had causal effects on rheumatoid arthritis in the reverse MR analysis. There was no heterogeneity or horizontal pleiotropy. Conclusions This MR analysis provides evidence of a positive causal association between rheumatoid arthritis and gestational hypertension, pre-eclampsia, fetal growth restriction and preterm delivery genetically. It highlights the importance of more intensive prenatal care and early intervention among pregnant women with rheumatoid arthritis to prevent potential adverse obstetric outcomes.

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Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Adverse Pregnancy Outcomes: A Bidirectional Two-Sample Mendelian Randomization Study

Chang,

Zhao,

Liu

et al. 2024

Preprint

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“…They monitored the values of total cholesterol, triglycerides, LDL-C, and HDL-C. A total of eight studies (over 14,000 pregnant women) were included in the analysis. The result of the research indicated that reduced values of total cholesterol, triglycerides, and LDL-C were risk factors for SGA (small for gestational age) fetuses (20).…”

Section: The Effect Of Dyslipidemia On the Fetusmentioning

confidence: 98%

The relevance of cholesterol and triglycerides in pregnancy

Milinčić¹,

Dugalić²,

Dugalić³

2023

Medicinska istraživanja

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Cholesterol participates in the construction of all body cells, steroid hormones, and bile acids. Its role in pregnancy is of key importance in the form of the synthesis of hormones without which conception and pregnancy would not be possible, and later in developing the physiological functions of the fetus as well. Triglycerides as the main energy substrate serve in the normal growth and development of the fetus. Normal reference values for lipid status in pregnancy have not been established yet. It has been proven that elevated, as well as reduced values of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) participate in pathological conditions of pregnancy - gestational diabetes mellitus, preeclampsia, macrosomia, restricted fetal growth, etc. The treatment of dyslipidemia is limited due to the lack of pharmacological studies on pregnant women, as well as the teratogenic effect of anti-lipid drugs. This review article deals with the effect of cholesterol and triglycerides on pregnancy, pregnancy outcomes, prenatal and postnatal effects on the fetus, as well as current and future treatment options.

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Effects of Physical Activity on Blood Lipids and Hemoglobin A1c in Healthy Pregnant Women: The FitMum Randomized Controlled Trial

Jensen,

Roland,

Knudsen

et al. 2024

Endocrine Practice

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Association between maternal lipid levels during pregnancy and delivery of small for gestational age: A systematic review and meta-analysis

Cited by 4 publications

References 44 publications

Rheumatoid Arthritis and Adverse Pregnancy Outcomes: A Bidirectional Two-Sample Mendelian Randomization Study

Rheumatoid Arthritis and Adverse Pregnancy Outcomes: A Bidirectional Two-Sample Mendelian Randomization Study

The relevance of cholesterol and triglycerides in pregnancy

Effects of Physical Activity on Blood Lipids and Hemoglobin A1c in Healthy Pregnant Women: The FitMum Randomized Controlled Trial

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