Association between maternal polycystic ovary syndrome and early childhood growth: a continuous observation from 3 months to 6 years of age

Zhang, Fangfang; Ying, Liying; Zhang, Qing; Wang, Fangfang; Qu, Fan

doi:10.1007/s10815-021-02378-9

Cited by 5 publications

(5 citation statements)

References 48 publications

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“…The babies born to PCOS mothers had a signi cantly higher risk of admission to a neonatal intensive care unit and a higher perinatal mortality, unrelated to multiple births [5]. A signi cantly higher prevalence of obesity, diabetes, cardiovascular disease was observed in offspring of women with PCOS, which could not be completely attributed to pregnancy complications, and seems to be more related to maternal PCOS condition [6][7][8][9], which our studies also lend support to [10][11][12]. Concerning neurobehavioral phenotypes, maternal PCOS has been reported to respectively increase the odds of offspring attention-de cit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) by 42% and 59% [13][14][15][16].…”

Section: Introductionsupporting

confidence: 63%

The neurodevelopment of neonates born to women with polycystic ovary syndrome: evidences from China

Shen

Dai

Yue

et al. 2023

Preprint

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Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Mothers with PCOS are at increased risk of various gestational complications and adverse outcomes of offspring. The health problems, including neurobehavioral phenotypes, of PCOS offspring has attracted wide attention and been associated with intrauterine environment changes due to maternal PCOS. Using neonatal behavioral neurological assessment (NBNA), we conducted measurement of neonate’s neurodevelopment on the third day after birth. Total score of NBNA and score of behavioral capacity, orientation response-animate visual and auditory, were significantly lower in PCOS group than those in control group. Concerning sex difference, we found significantly lower total score of NBNA and score of behavioral capacity, orientation response-inanimate visual, in male neonates of PCOS group compared to those of control group, while this did not exist in female neonates. In conclusion, our data indicated an association between maternal PCOS and offspring neurobehavior at the beginning of neonatal period in a sex-specific manner. Further evidence of intrauterine environment is required to clarify the potential mechanism underlying impacts of maternal PCOS on neurodevelopment.

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Section: Introductionsupporting

confidence: 63%

The neurodevelopment of neonates born to women with polycystic ovary syndrome: evidences from China

Shen

Dai

Yue

et al. 2023

Preprint

Self Cite

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“…According to Finland’s national birth cohort, maternal PCOS was significantly associated with a 1.58-fold increased risk of childhood obesity, a 1.37-fold increase in adolescent obesity, and a 2.06-fold increase in T2DM in early adulthood [ 51 ]. Zhang et al prospectively tracked the growth trajectory of the Ningbo birth cohort and obtained similar results [ 52 ]. In addition, Risal et al found that daughters of PCOS mothers had a five-fold increased risk of PCOS in a Swedish nationwide register-based cohort and a clinical case–control study from Chile [ 53 ].…”

Section: Challenges and Possible Solutions Of Pcosmentioning

confidence: 90%

Polycystic Ovary Syndrome: Challenges and Possible Solutions

Che

et al. 2023

JCM

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. This syndrome not only impairs female fertility but also increases the risk of obesity, diabetes, dyslipidemia, cardiovascular diseases, psychological diseases, and other health problems. Additionality, because of the high clinical heterogeneity, the current pathogenesis of PCOS is still unclear. There is still a large gap in precise diagnosis and individualized treatment. We summarize the present findings concerning the genetics, epigenetics, gut microbiota, corticolimbic brain responses, and metabolomics of the PCOS pathogenesis mechanism, highlight the remaining challenges in PCOS phenotyping and potential treatment approaches, and explain the vicious circle of intergenerational transmission of PCOS, which might provide more thoughts for better PCOS management in the future.

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“…It has been found that daughters of PCOS patients have a 5-fold higher risk of presenting PCOS than normal patients [29]. Moreover, it has been shown that daughters and sons of PCOS patients have an increased risk of metabolic and behavioral alterations, including lower APGAR scores in infants, delayed development and early growth, obesity, and T2D [14,15,30].…”

Section: Discussionmentioning

confidence: 99%

“…Children who gain weight rapidly during the first years of childhood are fatter and have more abdominal fat, increasing the risk of developing metabolic diseases in adulthood [47][48][49][50]. In addition, children of mothers with PCOS have a higher body mass index in early infancy and childhood [15,18]. The risk of developing metabolic diseases is increased in the presence of IR, and the concentration of insulin, triacylglycerols, and cholesterol is elevated before puberty and in adult life in the children of hyperandrogenic PCOS women [18,51,52].…”

Section: Discussionmentioning

confidence: 99%

“…In sheep, prenatal overexposure to androgens increases insulin production due to an excess of beta cells in females [13]. Studies on daughters of women with PCOS demonstrated its association with body weight and body mass index, which increases the risk of obesity and T2D [14,15]. Sons of women with PCOS showed higher weight during early infancy and developed IR and metabolic syndrome during adult life [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice

et al. 2022

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Polycystic ovary syndrome (PCOS) is an endocrine–metabolic disorder of unknown etiology. Hyperandrogenism (HA) is the main diagnostic criteria for PCOS, in addition to being a risk factor for developing several disorders throughout the patient’s life, including pregnancy. However, the impact on offspring is little known. Therefore, the aim of this work was to evaluate the effect of maternal HA on glucose metabolism and hepatic lipid accumulation in adult offspring. We used Balb/c mice treated with dehydroepiandrosterone (DHEA) for 20 consecutive days. The ovary of DHEA-treated mice showed hemorrhagic bodies, an increased number of atretic follicles, and greater expression of genes related to meiotic cell cycle and DNA repair. The DHEA offspring (O-DHEA) had low birth weight, and some pups showed malformations. However, O-DHEA individuals gained weight rapidly, and the differences between them and the control group became significantly greater in adulthood. Moreover, O-DHEA presented higher serum glucose after a 6 h fast and a larger area under glucose, insulin, and pyruvate tolerance test curves. Oil Red O staining showed a more significant accumulation of fat in the liver but no changes in serum cholesterol and triacylglycerol levels. In summary, our results show that HA, induced by DHEA, affects gene expression in oocyte, which in turn generates defects in embryonic development, insulin resistance, and alteration in hepatic gluconeogenesis and lipid metabolism in O-DHEA, thereby increasing the risk of developing metabolic diseases.

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Association between maternal polycystic ovary syndrome and early childhood growth: a continuous observation from 3 months to 6 years of age

Cited by 5 publications

References 48 publications

The neurodevelopment of neonates born to women with polycystic ovary syndrome: evidences from China

The neurodevelopment of neonates born to women with polycystic ovary syndrome: evidences from China

Polycystic Ovary Syndrome: Challenges and Possible Solutions

Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice

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