Association between mean platelet volume and hypertension incidence

Li, Gang; Zhang, Yanyan; Zhu, Zhenggang; Du, Juan

doi:10.1038/hr.2017.30

Cited by 47 publications

(38 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study Diabetics hypertensive dyslipidemics and overweight (BMI>25) cases had significantly raised values of MPV and PDW. The findings were in line with studies conducted by Gang L et al, 16 Kodiatte TA 17 and Khemka R. 18 There was no significant difference in MPV, PDW according to gender, smoking and alcoholism. MPV & PDW were higher in patients aged more than 60 years of age compared to those less than 60 years of age.…”

Section: Mpv Pdw and Risk Factors For Strokesupporting

confidence: 90%

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

Narasimhamurthy¹,

Ramesh²,

Chaitanya³

2019

jebmh

View full text Add to dashboard Cite

BACKGROUND Stroke is a global health problem. Platelet activation & aggregation are critical in pathogenesis of acute ischemic stroke. The mean platelet volume (MPV) and platelet distribution width (PDW) are laboratory markers associated with platelet function and activity. Increased values in thromboembolic disease is reflected as an important risk factor. We wanted to assess the severity of acute ischemic stroke according to modified Rankin scale and determine the value of mean platelet volume and platelet distribution width. We also wanted to establish the correlation between mean platelet volume, platelet distribution width with the severity of acute ischemic stroke and correlate the value of mean platelet volume, platelet distribution width with other risk factors for stroke. METHODS A prospective study was undertaken among patients admitted in ESIC Medical College & PGIMSR from January 2017 to June 2018. Study comprised of around 150 cases of acute ischemic stroke without previous thrombotic events. Severity of ischemic stroke was assessed by the Modified Rankin Scale. Patients were divided into 2 groups based on Rankin score (Group 1: Score 0-2, and Group 2: Score 3 or more). Blood samples were taken to measure MPV and PDW. RESULTS MPV and PDW were significantly elevated in patients who suffered a severe stroke defined as modified Rankin score of 3 to 6. Patients with higher MPV had worse outcome at the end of one week. After controlling for the risk profile associated with ischemic stroke in the multivariate logistic regression model, the effect of MPV in ischemic stroke remained statistically significant. CONCLUSIONS MPV and PDW can be considered as laboratory markers for the risk of acute ischemic stroke. The MPV is associated with ischemic stroke severity and has a high value for discriminating severe from mild ischemic stroke.

show abstract

Section: Mpv Pdw and Risk Factors For Strokesupporting

confidence: 90%

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

Narasimhamurthy¹,

Ramesh²,

Chaitanya³

2019

jebmh

View full text Add to dashboard Cite

show abstract

“…Hypertension, diabetes mellitus, dyslipidemia, coronary artery disease, and smoking habits are among the most important medical pre-conditions and stroke-related comorbidities. Several lines of evidence from the literature suggest that a direct correlation exists between MPV and these traditional cerebrovascular risk factors [55][56][57][58][59][60]. MPV was significantly higher (0.65 fL) in individuals with coronary artery disease and patients with high MPV had 17% higher chance of having cardiovascular events compared to patients with low MPV [61].…”

Section: Discussionmentioning

confidence: 99%

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

View full text Add to dashboard Cite

Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD) = − 0.30, (95% CI: − 0.49 to − 0.11), N = 2492, P = .002] compared with controls (N = 3615). The MPV was significantly higher [SMD = 0.52 (95% CI: 0.28-0.76), N = 2739, P < .001] compared with controls (N = 3810). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD = −0.18, 95% CI: −0.35-0.01) and hemorrhagic stroke (−0.94, −1.62 to −0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (−0.36, −0.68 to −0.04). Ischemic stroke patients had higher MPV (0.57, 0.31-0.83), and samples by Ethylenediaminetetraacetic acid (EDTA) anticoagulant showed significantly higher result for patients compared to controls (0.86, 0.55--1.17). PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. These characteristics might be related to AS and associated with it. It is advisable to pay attention to elapsed time between phlebotomy and hematology analysis, anticoagulant and hemocytometer types in AS. Systematic review registration: This meta-analysis is registered on the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42017067864 (https:// www.crd.york.ac.uk/prospero/display_record.php?RecordID=67864).

show abstract

“…Mean platelet volume (MPV), an easily and inexpensive parameter derived from routine blood counts, is usually used to evaluate platelet morphology and can be used as an indicator of platelet activity [ 7 ]. Elevated MPV has been demonstrated to be related to cardiovascular diseases and its risk factors such as T2DM, hypertension, and nonalcoholic fatty liver disease (NAFLD) [ 8 – 11 ]. Recently, a substantial number of studies measured MPV levels in women with GDM to evaluate whether it can be used as an indicator to monitor and assess the development of GDM.…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Zhou

Chen

Sun

et al. 2018

Journal of Diabetes Research

View full text Add to dashboard Cite

Aim To evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM). Methods A systematic literature search was performed in PubMed, EMBASE, Web of Science, and The Cochrane Library up to 4 September 2017. Pooled standardized mean differences (SMD) and 95% confidence interval (CI) were calculated using a random-effect model. Results Nineteen studies comprising 1361 GDM patients and 1911 normal pregnant women were included. MPV was increased in GDM patients when compared with healthy pregnant women (SMD: 0.79; 95% CI: 0.43–1.16; P < 0.001). Subgroup analyses revealed that such trend was consistent in the third-trimester (SMD: 1.35; 95% CI: 0.72–1.98), Turkish (SMD: 0.81; 95% CI: 0.43–1.19), and Italian (SMD: 2.78; 95% CI: 2.22–3.34) patients with GDM and the patients diagnosed based on Carpenter and Coustan criteria (SMD: 1.04; 95% CI: 0.42–1.65). Significantly higher MPV also were observed within cross-sectional studies (SMD: 0.99; 95% CI: 0.49–1.49). Remarkable between-study heterogeneity and potential publication bias were observed in this meta-analysis; however, sensitivity analysis indicated that the results were not unduly influenced by any single study. Conclusions GDM patients are accompanied by increased MPV, strengthening the clinical evidence that MPV may be a predictive marker for GDM.

show abstract

Association between mean platelet volume and hypertension incidence

Cited by 47 publications

References 33 publications

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About