Association between medication adherence and health-related quality of life of patients with diabetes

Abstract

Purpose The purpose was to evaluate the association between medication adherence and health-related quality of life (HRQoL) of patients with diabetes. Methods In this cross-sectional study, a total of 518 patients were recruited from the outpatient departments of different general public and private hospitals in Greece during the COVID-19 pandemic using a consecutive sampling method. HRQoL was assessed with the EQ-5D-5L instrument and medication adherence with the corresponding subscale of the Adherence Starts with Knowledge 20 questionnaire. The relationship between HRQoL and adherence was explored by employing Spearman’s correlations and multiple binary logistic and linear stepwise regressions using robust standard errors. Results A total of 15.1 and 1.9% of the patients reported that they had taken a medicine either more or less often than prescribed in the last month and week, respectively. Statistically significant but modest correlations of medication non-adherence with the EQ-5D index (rho = − 0.223), EQ-VAS (rho = − 0.230), and all the HRQoL domains (rho ranging from 0.211, for pain/discomfort, to 0.136, for mobility issues) were found. These significant associations persisted even after controlling for several other known potential factors of HRQoL in the multivariable analyses, except for the mobility and anxiety/depression dimensions. Conclusion Medication non-adherence appears to be independently associated with lower HRQoL and health levels in patients with diabetes. It is crucial to plan interventions to enhance medication adherence not only to obtain greater value from the available resources, but also to improve HRQoL of patients with diabetes.

Predicting Factors of Health-Related Quality of Life Among Adults With Type 2 Diabetes: A Systematic Review

“…In 18 primary studies, gender was determined as a significant predictor of HRQoL. Females were shown to have significantly poorer HRQoL and the most statistically significant in the physical and psychological domain ( Al Hayek et al, 2014 ; Alsayed Hassan et al, 2022 ; Alshayban & Joseph, 2020 ; Barua et al, 2021 ; Bourdel-Marchasson et al, 2013 ; Chantzaras & Yfantopoulos, 2022 ; Chew et al, 2015 ; Gebremedhin et al, 2019 ; Hamady et al, 2022 ; Natarajan & Mokoboto-Zwane, 2022 ; Nguyen et al, 2018 ; Saleh et al, 2015 ; Shamshirgaran et al, 2016 ; Tran Kien et al, 2021 ; Wan et al, 2016 ; Wonde et al, 2022 ; Zare et al, 2020 ) in particular, on the dimensions of physical functioning, emotional role, energy, emotion, social functioning, and pain ( Al Hayek et al, 2014 ).…”

“…One of the factors that affected HRQoL was age. The majority of studies revealed that patients with older age have lower HRQoL ( Alsayed Hassan et al, 2022 ; Bourdel-Marchasson et al, 2013 ; Chantzaras & Yfantopoulos, 2022 ; Gebremariam et al, 2022 ; Kalayou Haftu et al, 2022 ; Kang et al, 2021 ; Saleh et al, 2015 ; Tran Kien et al, 2021 ; Wan et al, 2016 ; Zare et al, 2020 ).…”

“…Monthly household income or economic status as a strong predictor of HRQoL was analyzed in nine studies with 2,466 enrolling participants ( Al Hayek et al, 2014 ; Alshayban & Joseph, 2020 ; Barua et al, 2021 ; Bourdel-Marchasson et al, 2013 ; Chantzaras & Yfantopoulos, 2022 ; Gebremariam et al, 2022 ; Kalayou Haftu et al, 2022 ; Natarajan & Mokoboto-Zwane, 2022 ; Shamshirgaran et al, 2016 ). Poor economic status was significantly associated with poor HRQoL.…”

How Does Dietary Intake Relate to Dispositional Optimism and Health-Related Quality of Life in Germline BRCA1/2 Mutation Carriers?

“…HRQoL is defined as the impact a disease and its treatment have on a patient’s physical, functional, psychological, social, and financial well-being [ 2 , 3 , 4 ]. In cancer care, there is a growing recognition of the significance of HRQoL, as reduced HRQoL may result in lower treatment adherence [ 5 ] and an increased risk of mortality [ 6 ]. A more comprehensive definition of HRQoL could encompass dispositional optimism, which is a psychological attribute associated with health advantages [ 7 ].…”

COVID-19, diabetes mellitus type 2, endocrine genetics, and pituitary and adrenal diseases

“…Although not a diabetes journal per se, Hormones publishes a fair amount of data and findings on diabetes research. The most recent publication by Chantzaras et al [9] and studies by a number of other authors previously underscore our abiding interest in the causes and pathophysiology, genetics, and treatment, as well as clinical complications of the various types of diabetes. In this issue, there are two excellent studies on BNP levels and erectile dysfunction in type 2 diabetes mellitus [10,11], one focusing on continuous insulin infusion treatment [12], as well as an animal study of diabetic peripheral neuropathy [13].…”