Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis

Nucci, Daniele; Sommariva, Andrea; Degoni, Luca Mario; Gallo, Giulia; Mancarella, Matteo; Natarelli, Federica; Savoia, Antonella; Catalini, Alessandro; Ferranti, Roberta; Pregliasco, Fabrizio Ernesto; Castaldi, Silvana; Gianfredi, Vincenza

doi:10.1007/s40520-024-02718-6

Cited by 11 publications

(2 citation statements)

References 87 publications

(182 reference statements)

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“…As presented in Table 1 , considering only the most recent years, there are a number of reliable systematic reviews showing its protective effect. A high adherence to the Mediterranean diet had been associated with a reduced risk of all-cause mortality, cardiovascular disease risk, type 2 diabetes, cancer risk and mortality from all causes in cancer survivors [ 17 , 33 , 34 , 35 , 36 , 37 , 38 ]. Table 1 show a summary of the systematic reviews related to the relationship between adherence to the Mediterranean diet and the risk of developing different non-communicable chronic diseases and cognitive decline with updated data from over the last few years and incorporating relevant new evidence.…”

Section: Mediterranean Diet Non-communicable Chronic Diseases and Mor...mentioning

confidence: 99%

Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach

Dobroslavska,

Silva,

Vicente

et al. 2024

Nutrients

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The global population is on a trajectory of continuous growth, with estimates projecting an increase from 7.7 billion in 2019 to approximately 9.7 billion by 2050. Longevity is also expected to rise rapidly, with advancements in healthcare contributing to increased life expectancies and an increase in the maximum lifespan. The aging process is accompanied by different changes, often leading to a decline in daily life activities and an increased susceptibility to disease. Age-related changes can cause cellular damage and subsequent cellular death. Oxidative stress and inflammation play significant roles in this process contributing to molecular damage and mitochondrial dysfunction. Active aging has been associated with improved quality of life and a reduced risk of morbidity and premature mortality. In this context, the Mediterranean diet has emerged as a promising approach to promoting healthy aging and sustainability. The phytochemical compounds within the Mediterranean diet have been linked to a lower risk of developing cardiovascular disease, type 2 diabetes, obesity, cancer and neurodegenerative diseases. The findings of peer-reviewed articles regarding the use of the Mediterranean diet as a healthy and sustainable dietary pattern written in Portuguese, Spanish or English were included in this narrative literature review. This dietary pattern’s emphasis on the consumption of fresh and local food aligns with both health and environmental sustainability goals. This work provides a comprehensive review of the benefits of the Mediterranean diet and its components in a healthy aging process and highlights the importance of this dietary pattern as a sustainable approach.

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Section: Mediterranean Diet Non-communicable Chronic Diseases and Mor...mentioning

confidence: 99%

Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach

Dobroslavska,

Silva,

Vicente

et al. 2024

Nutrients

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“…As such, it has already been linked to a number of favorable health outcomes, first and foremost in the prevention of cardiovascular disease [20]. More recently, research has explored its role in the neuropsychological domain, such as in the prevention of Alzheimer's disease or the treatment of depression [21,22].…”

Section: Introductionmentioning

confidence: 99%

Study Protocol for the Residents’ Mental Health Investigation, a Dynamic Longitudinal Study in Italy (ReMInDIt)

Caminiti,

Mercogliano,

Cussotto

et al. 2024

Healthcare

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Medical residents constitute a vulnerable population susceptible to mental health disorders. In Italy, this was evident during the COVID-19 pandemic, when medical residents served on the front line and provided significant support to healthcare services. Therefore, the working group on “Public Mental Health” of the Medical Residents’ Council of the Italian Society of Hygiene, Preventive Medicine, and Public Health (S.It.I.) designed the “Residents’ mental health investigation, a dynamic longitudinal study in Italy” (ReMInDIt). This longitudinal study aims to assess the mental status of medical residents and to explore potential cause–effect relationships between risk/protective factors (identified among sociodemographic, residency program, and lifestyle characteristics) and mental health outcomes (anxiety and depressive symptoms). Data will be collected from a study population of 3615 residents enrolled in Italian residency programs in public health, occupational medicine, and forensic medicine through an online questionnaire that includes validated tools, requires 10 min for completion, and is disseminated by the residents’ Councils. It will be followed by a follow-up administration after 12 months. The ReMInDIt study will play a significant role in generating evidence crucial for enhancing mental health services and promoting protective factors for the mental well-being of this important segment of healthcare professionals.

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Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer’s Disease

Dziewa,

Złotek,

Herbet

et al. 2024

Cell Mol Neurobiol

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Alzheimer’s disease (AD) is a condition characterized by the gradual degeneration of the nervous system that poses significant challenges to cognitive function and overall mental health. Given the increasing global life expectancy, there is an urgent need for effective strategies to prevent and manage Alzheimer’s disease, with a particular focus on anti-aging interventions. Recent scientific advancements have unveiled several promising strategies for combating Alzheimer’s disease (AD), ranging from lifestyle interventions to cutting-edge pharmacological treatments and therapies targeting the underlying biological processes of aging and AD. Regular physical exercise, cognitive engagement, a balanced diet, and social interaction serve as key pillars in maintaining brain health. At the same time, therapies target key pathological mechanisms of AD, such as amyloid-beta accumulation, tau abnormalities, neuroinflammation, mitochondrial dysfunction, and synaptic loss, offering potential breakthroughs in treatment. Moreover, cutting-edge innovations such as gene therapy, stem cell transplantation, and novel drug delivery systems are emerging as potential game-changers in the fight against AD. This review critically evaluates the latest research on anti-aging interventions and their potential in preventing and treating Alzheimer’s disease (AD) by exploring the connections between aging mechanisms and AD pathogenesis. It provides a comprehensive analysis of both well-established and emerging strategies, while also identifying key gaps in current knowledge to guide future research efforts.

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Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis

Cited by 11 publications

References 87 publications

Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach

Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach

Study Protocol for the Residents’ Mental Health Investigation, a Dynamic Longitudinal Study in Italy (ReMInDIt)

Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer’s Disease

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