Association between menstrual cycle irregularity and tinnitus: a nationwide population-based study

Abstract

This population-based cross-sectional study investigated the association between menstrual cycle irregularity and tinnitus in premenopausal Korean women. We used data from the 5th Korea National Health and Nutrition Examination Survey (2010–2012). A total of 4633 premenopausal women were included. Hierarchical multivariable logistic regression analysis was performed. Individuals with tinnitus accounted for 21.6%. Women with tinnitus or menstrual irregularity had significantly higher rates of stress, depressive mood, and suicidal ideation than those without. The proportion of individuals with irregular menstrual cycles with duration of longer than 3 months increased as the severity of tinnitus increased (P = 0.01). After adjusting for confounding variables, the odds of tinnitus increased in individuals with irregular menstrual cycles compared to those with regular menstrual cycles. The odds ratios (ORs) of tinnitus tended to increase as the duration of menstrual irregularity became longer (1.37, 95% confidence interval: 1.06–1.78 for duration of up to 3 months; 1.71, 1.03–2.85 for duration of longer than 3 months, P for trend = 0.002). Our study found a positive association between menstrual cycle irregularity and tinnitus. Menstrual cycle irregularity may be a related factor of tinnitus in women with childbearing age.

Menstrual irregularities and vaginal bleeding after COVID-19 vaccination reported to v-safe active surveillance, USA in December, 2020–January, 2022: an observational cohort study

“…Manual review of v-safe responses suggested some reports of breast tenderness, mood changes, and tinnitus; these symptoms could be related to hormonal changes, which could disrupt normal menstruation, menopause, or pre-existing amenorrhea secondary to medications or other medical conditions. 24 Menstrual cycle prolongation has been associated with receiving two COVID-19 vaccine doses within the same cycle, 12 supporting the hypothesis that immune response to vaccination can affect the hypothalamic–pituitary–ovarian axis. Temporary menstrual irregularities have been reported after SARS-CoV-2 infection.…”

Tinnitus, Suicide, and Suicidal Ideation: A Scoping Review of Primary Research

“…Included records were published across 1992-2023. We found notable variation in the use of terms to describe suicidal ideation and behaviours (e.g., "suicide wishes" [41], "unsuccessful suicide attempts… successful suicide attempts" [8], "committed suicide" [42] "committing suicide" [43][44][45]. In reporting on the primary studies catalogued, terminology used by authors was retained to present their findings accurately.…”

Mood swing during menstruation: Confounding factors and drug use

“…Manifestations of PMS include mood swing, irritability, depression, anger, anxiety, insomnia, breast tenderness, change in appetite, food craving, muscle pain, tinnitus, fatigue, oedema, bloating, social withdrawal, absenteeism from work/school, and poor work/academic performance ( 9 , 13 , 14 , 15 , 16 ). PMS management include administration of antidepressants like selective serotonin reabsorption inhibitors (SSRIs); others include non-steroidal anti-inflammatory drugs (NSAIDs) and OCPs, while non-drug management include intake of mineral supplements such as calcium and magnesium, intake of vitamins A, E and B 6 , exercising, yoga, and stress reduction programs ( 2 , 4 , 17 ).…”