Association between metabolic abnormalities and hepatitis C-related hepatocellular carcinoma

Khattab, Mahmoud A.; Eslam, Mohammed; Mousa, Yousef; Ela-adawy, Nosa; Fathy, Shimaa; Shatat, Mohammed; Abd-Aalhalim, Hesham; Kamal, Amal; Sharawe, Mohammed A.

doi:10.1016/s1665-2681(19)31462-0

Cited by 46 publications

(31 citation statements)

References 24 publications

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“…This suggestion was strongly supported by the significant negative correlations which were found between serum adiponectin levels and both the number of hepatic tumor foci and the overall size of the tumor. These significant negative correlations were also reported by Khattab et al [31] who found that adiponectin and adiporeceptor 1 expression rates were significantly lower in HCC than non-neoplastic hepatic tissues.…”

Section: Discussionsupporting

confidence: 84%

Assessment of serum adiponectin in Egyptian patients with HCV-related cirrhosis and hepatocellular carcinoma

Hamdy

Swaff

Hussein

et al. 2015

J Endocrinol Invest

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Section: Discussionsupporting

confidence: 84%

Assessment of serum adiponectin in Egyptian patients with HCV-related cirrhosis and hepatocellular carcinoma

Hamdy

Swaff

Hussein

et al. 2015

J Endocrinol Invest

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“…Although several studies have found clues to the relationships between HDL and hepatitis or HCC [5, 23–25], we are the first to predict prognoses of HCC patients by their HDL PO levels in both training and validation groups, and to extend this predictive value to low-recurrent-risk subgroups, thereby strengthening the clinical utility of this commonly accessible test to predict HCC recurrence. As serum HDL is analyzed routinely in clinical laboratories, detection of HDL PO can easily be standardized for early decision-making to tailor the most effective therapy for each HCC patients.…”

Section: Discussionmentioning

confidence: 80%

A new use for an old index: preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections

et al. 2017

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BackgroundHepatocellular carcinoma has high incidence and mortality worldwide. Liver is the site of most metabolic biotransformation, which could reflect the status of cells. Most plasma apolipoproteins, endogenous lipids and lipoproteins are synthesized in the liver. Therefore, the effects of lipid metabolites on prognosis of HCC deserved to be explored.MethodsWe prospectively included 58 healthy donors (HD), 50 chronic hepatitis (CH) patients and a training cohort of 189 patients with HCC who underwent curative resections at Zhongshan Hospital from January 2012 to August 2012. We identified the optimal HDLPO cutoff value at 0.98 mmol/L and used it to stratify patients into low- or high-HDLPO groups for the entire cohort and four low-recurrent-risk subgroups. We also included an independent validation group of 182 HCC patients to validate this cutoff value. Prognostic values of HDLPO and other factors were determined by Kaplan–Meier curves and the Cox proportional hazards model.ResultsThe low-HDLPO group had a higher median tumor grade (P = 0.020) and a higher recurrence rate (P = 0.032). Results of multivariate analysis showed that preoperative γ-glutamyl transpeptidase (GGT) and HDLPO were independent predictors of recurrence. Moreover, the predictive value of HDLPO was retained in four low-recurrent-risk subgroups. As expected, clinicopathologic characteristics and predictive values were similar in the validation and training cohorts.ConclusionsHDLPO is an accessible predictor of HCC recurrence after liver resections that can help identify patients who need more careful monitoring and follow-up care.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0509-3) contains supplementary material, which is available to authorized users.

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“…There is a significant inverse correlation between serum HDL-C level and the risk of cancer, which is independent of age, sex, BMI, diabetes, LDL-C, and smoking history [26]. On the other hand, HCC patients show lower levels of serum TC, HDL-C, LDL-C, and triglycerides compared to patients with CHC and controls [27,28]. Low serum level of LDL-C even serves as a significant and independent predictor of HCC in patients with CHB or CHC [29-31].…”

Section: Discussionmentioning

confidence: 99%

High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma

et al. 2014

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BackgroundNonalcoholic fatty liver disease (NAFLD) is a risk factor for hepatocellular carcinoma (HCC), but the association between a high-fat diet (HFD) and HCC is not fully understood. In this study, we investigated whether a high-saturate-fat diet affects hepatocarcinogenesis induced by administration of diethylnitrosamine (DEN).MethodsAdult SD rats were randomized into the following groups: normal chow diet (NCD), HFD, NCD + DEN, and HFD + DEN. The HFD contains 2% cholesterol and 10% lard oil. In mice with DEN treatment, the carcinogen was given via gavage. Mice were sacrificed at the end of 10, 12, and 14 weeks, respectively. The effects of HFD on hepatic carcinogenesis were assessed by HCC incidence, tumor differentiation, and the number and size of tumor nodules. Western blot and immunohistochemistry for proliferating cell nuclear antigen (PCNA), enzyme-linked immunosorbent assay (ELISA) for caspase-3, and real-time PCR for TNF-α and IL-6 further uncovered the proliferative and apoptotic properties of liver.ResultsIn contrast to the NCD group, DEN treatment (NCD + DEN group) led to hepatitis, cirrhosis, hepatic tumor, and decreased body weight. Interestingly, HFD, which induced hyperlipidemia and hepatic steatosis, attenuated DEN-related malnutrition and fibrosis progression in HFD + DEN group during 10–14 weeks. Moreover, the HFD + DEN group exhibited that the proportion of well differentiated HCC was much higher than that of NCD + DEN group. The number and average volume of HCC node were also significantly lowered in HFD + DEN group (P < 0.01-0.05). When compared to that of NCD + DEN group, there was an inhibited expression of PCNA, TNF-α, and IL-6, and activation of caspase-3 in the liver of HFD + DEN group at week 10 and 12.ConclusionsHFD restores malnutrition in the DEN-treated rats, which in turn inhibits the initiation of hepatic carcinogenesis and malignancy.

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Association between metabolic abnormalities and hepatitis C-related hepatocellular carcinoma

Cited by 46 publications

References 24 publications

Assessment of serum adiponectin in Egyptian patients with HCV-related cirrhosis and hepatocellular carcinoma

Assessment of serum adiponectin in Egyptian patients with HCV-related cirrhosis and hepatocellular carcinoma

A new use for an old index: preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections

High-saturate-fat diet delays initiation of diethylnitrosamine-induced hepatocellular carcinoma

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