Association between metabolic syndrome and pelvic organ prolapse severity

Abstract

Introduction and hypothesisAs in the case of cardiovascular and metabolic diseases, the prevalence of pelvic organ prolapse (POP) has been rising with the increasing proportion of elderly women in the population. The purpose of the present cross-sectional study was to evaluate the components of metabolic syndrome (MS) in urogynecological patients with a variable POP severity.MethodsThe MS risk factors (elevated waist circumference, elevated triglycerides, decreased high-density lipoprotein cholesterol, elevated blood pressure, hyperglycemia) were assessed in 100 women who were referred to our urogynecological center with pelvic floor disorders (PFD). POP was evaluated with the Pelvic Organ Prolapse Quantification system (POP-Q).ResultsThe χ2 test revealed that the diagnosis of MS and the presence of elevated triglycerides increased with the overall POP-Q stage. The other MS risk factors were not significantly associated with the overall POP-Q stage. MS and elevated triglycerides were predictors of the POP-Q stage ≥III [odds ratio (OR) 3.5, 95 % confidence interval (CI) 1.5–8.2 for MS and OR 3.4, 95 % CI 1.4–8.2 for elevated triglycerides, p < 0.01].ConclusionsThe diagnosis of MS and the presence of elevated triglycerides may be associated with the severity of POP in urogynecological patients. Longitudinal studies are required to assess whether the MS risk factors might predict the progression of POP and whether elimination of the risk factors might improve the prognosis in POP patients.

Retrospective comparison between the Prolift and Elevate anterior vaginal mesh procedures: 18-month clinical outcome

“…Pelvic examination was performed with the patient in the dorsal lithotomy position. The POP-Q system was used to quantify the POP severity at a maximum Valsalva strain [12,15,16].…”

“…The patients with grade ≥1 or showing a positive cough stress test were considered to have SUI. The OAB symptoms were assessed using questions selected from the Pelvic Floor Distress Inventory [16,19] (BDo you usually experience frequent urination?B, BDo you usually experience a strong feeling of urgency to empty your bladder?^, BDo you usually experience urine leakage associated with a feeling of urgency, that is, a strong sensation of needing to go to the bathroom?^). The patients who answered Byes^to any of the questions were considered to have OAB [16].…”

Prevalence and risk factors for pelvic organ prolapse in female citizens of Baku

“…В настоящее время опублико-ваны многочисленные работы по разработке новых методов лечения ВЖПО, постоянно совершенствуются методы хирургическо-го лечения. Практически во всех развитых странах мира разработаны клинические про-токолы диагностики и лечения ВЖПО [1][2][3][4][5][6]. В то же время есть трудности раннего начала лечебно-профилактических мероприятий [7].…”

“…Установленный возрастной интервал для отбора единицы наблюдения обусловлен большей распространённостью ВЖПО по данным литературы в этих возрастных группах [1][2][3][4][5][6]. Наблюдение проведено про-спективно на базе женской консультации 7-го родильного дома в г. Баку.…”

Association of matrix metalloproteinase‐10 polymorphisms with susceptibility to pelvic organ prolapse

“…Epidemiological studies have revealed that the incidence of POP in women between 51 and 60 years old is 0.33%, whereas in women over 60 years old it is up to 0.71%. In addition, only 11% of POP patients undergo surgical treatment, and among them, 25% may relapse . POP manifests a number of clinical features.…”