Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults

Akbaraly, Tasnime; Kivimäki, Mika; Brunner, Eric J.; Chandola, Tarani; Marmot, Michael; Singh‐Manoux, Archana; Ferrie, Jane E.

doi:10.2337/dc08-1358

Cited by 137 publications

(148 citation statements)

References 23 publications

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“…These associations may in part explain why people with psychopathology are at high risk of developing a range of chronic illnesses 9. Metabolic syndrome has been defined as a discrete, binary entity; however, previous research indicates that some components are more strongly associated with psychopathology than others, particularly obesity and dyslipdemia 10, 11, 12. Given these discrepancies between components in the context of psychiatric illness, using a dichotomous definition of metabolic syndrome may not be the strongest way of identifying the nature of associations between psychopathology and metabolic dysregulation.…”

Section: Introductionmentioning

confidence: 99%

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

et al. 2016

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BackgroundMetabolic syndrome components—waist circumference, high‐density lipoprotein cholesterol (HDL‐C), triglycerides, systolic blood pressure and fasting glucose—are cross‐sectionally associated with depression and anxiety with differing strength. Few studies examine the relationships over time or whether antidepressants have independent effects.MethodsParticipants were from the Netherlands Study of Depression and Anxiety (NESDA; N = 2,776; 18–65 years; 66% female). At baseline, 2‐ and 6‐year follow‐up, participants completed diagnostic interviews, depression and anxiety symptom inventories, antidepressant use assessment, and measurements of the five metabolic syndrome components. Data were analyzed for the consistency of associations between psychopathology indicators and metabolic syndrome components across the three assessment waves, and whether psychopathology or antidepressant use at one assessment predicts metabolic dysregulation at the next and vice versa.ResultsConsistently across waves, psychopathology was associated with generally poorer values of metabolic syndrome components, particularly waist circumference and triglycerides. Stronger associations were observed for psychopathology symptom severity than diagnosis. Antidepressant use was independently associated with higher waist circumference, triglycerides and number of metabolic syndrome abnormalities, and lower HDL‐C. Symptom severity and antidepressant use were associated with subsequently increased number of abnormalities, waist circumference, and glucose after 2 but not 4 years. Conversely, there was little evidence that metabolic syndrome components were associated with subsequent psychopathology outcomes.ConclusionsSymptom severity and antidepressant use were independently associated with metabolic dysregulation consistently over time and also had negative consequences for short‐term metabolic health. This is of concern given the chronicity of depression and anxiety and prevalence of antidepressant treatment.

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Section: Introductionmentioning

confidence: 99%

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

et al. 2016

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“…It is associated with increased risk of subclinical atherosclerosis, cardiovascular disease (CVD), diabetes, and mortality. 1,2 In the past decades, several studies have reported a significant association between the MetS and depression among young 3,4 and older adults. [5][6][7][8][9][10][11] A recent meta-analysis indicates that the relationship between the MetS and depression is probably bidirectional.…”

Section: Introductionmentioning

confidence: 99%

Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study

Ruas

Diniz

Firmo

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To investigate the moderating effect of an increasing number of clustered metabolic syndrome (MetS) components on the association between MetS and depressive symptoms in a population-based cohort of older adults in Brazil.Methods: This analysis used data from the Bambuí Cohort Aging Study. Participants in this cross-sectional study comprised 1,469 community-dwelling older people aged X 60 years. Analyses were performed to assess both the association between depressive symptoms and each individual MetS component and the association between depressive symptoms and clustering of an increasing number of MetS components.

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“…28, 29 It has also been reported that metabolic syndrome, in particular obesity, is predictive of depressive symptoms. 30 Although BP measurements at physician check-up were well controlled in both groups, ABPM-measured nocturnal and early morning BP were significantly higher in the anxiety group than in the control group. Further, the relative risk of existing anxiety disorder was significantly higher in the risertype hypertension than that in the dipper-type hypertension.…”

Section: Discussionmentioning

confidence: 99%

Anxiety Disorder Is Associated With Nocturnal and Early Morning Hypertension With or Without Morning Surge

Kayano

Koba

Matsui

et al. 2012

Circ J

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Background: Nocturnal and early morning hypertension are both significant risk factors for cardiovascular events. It remains unclear whether anxiety disorder affects nocturnal blood pressure (BP), early morning BP, or BP pattern in hypertensive patients. Methods and Results:One hundred and twenty consecutive hypertensive outpatients (77 men and 43 women; mean age, 66±11 years) were divided into 2 groups based on Hospital Anxiety and Depression Scale (HADS) score: a control group (n=78; HADS ≤10) and an anxiety group (42 patients; HADS ≥11). Nocturnal BP, early morning BP, morning BP surge (defined as BP rise ≥50 mmHg), and BP pattern (extreme-dipper/dipper/non-dipper/riser) were measured on ambulatory BP monitoring. Clinical characteristics and BP were also evaluated at physician check-up. There was no significant difference between the 2 groups for BP check-up, but nocturnal and early morning BP were significantly higher in the anxiety group (142±16 mmHg and 152±21 mmHg) than in the control group (126±14 mmHg and 141±18 mmHg). With regard to patients with morning BP surge, nocturnal and early morning BP were also significantly higher in the anxiety group. The relative risk of existing anxiety disorders in riser-type hypertension was 4.48-fold higher (95% confidence interval: 1.58-12.74; P<0.005) than in dipper-type hypertension. Conclusions:Anxiety disorder is associated with nocturnal and early morning hypertension, and may be a risk factor for cardiovascular events. (Circ J 2012; 76: 1670 - 1677

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Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults

Cited by 137 publications

References 23 publications

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study

Anxiety Disorder Is Associated With Nocturnal and Early Morning Hypertension With or Without Morning Surge

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