Association Between Metabolic Syndrome and Atopic Dermatitis in Korean Adults

Lee, Ji Hyun; Jung, Han Mi; Han, Kyung Do; Lee, Seung Hwan; Lee, Jun Young; Park, Yong Gyu; Park, Young Min

doi:10.2340/00015555-2441

Cited by 31 publications

(54 citation statements)

References 31 publications

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“…). A total of 16 publications were included in the qualitative analysis and further details about the publications are presented online and below (Tables S1–S6; see Supporting Information) …”

Section: Resultsmentioning

confidence: 99%

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

et al. 2018

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Section: Resultsmentioning

confidence: 99%

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

et al. 2018

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“…A positive association between AD and hypertension was observed in 6 out of 11 studies [1,2,15,18,22,24], 3 studies [12,17,23] found an inverse association, and 2 studies [19,32] did not find any association. The study by Uehara et al [12] with physician's diagnosed AD and measured blood pressure found no association.…”

Section: Discussionmentioning

confidence: 96%

“…Lee et al [18] found that women with AD were more likely to have hypertriglyceridemia than women without AD. It has been suggested that AD might influence lipid metabolism and trigger the accumulation of triglycerides resulting in metabolic syndrome [11].…”

Section: Discussionmentioning

confidence: 99%

“…In a nationally representative Korean cross-sectional survey, the Korea National Health and Nutrition Examination Survey (KNHANES study), Lee et al [18] investigated whether metabolic syndrome and its components were risk factors for AD. The KNHANES study is organized by the Korean Ministry of Health and Welfare and has been conducted annually since 1998.…”

Section: Ad and Metabolic Syndromementioning

confidence: 99%

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Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

et al. 2018

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Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardiovascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A total of 14 studies, investigating the association between AD and the metabolic syndrome or AD and components of metabolic syndrome fulfilled the inclusion criteria and were included. It seems unlikely that the association between AD and metabolic syndrome is causal. However, women with AD tended to have components of metabolic syndrome more often than women without AD. There was a positive association between AD and central obesity measured as waist circumference, and this association was stronger for women than men. Despite conflicting results regarding hypertension, the association between hypertension and AD also appeared stronger for women. On the other hand, the association between AD and hyperglycemia appears unlikely, and the association between AD and cholesterol levels was inconsistent. In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men.

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“…Recent observational studies have reported an association between AD, the metabolic syndrome, and its components and complications. A national Korean cross‐sectional study of 5007 adults aged 19–40 found that AD was associated with the metabolic syndrome and some of its components in females (OR = 2.92, 95% CI: 1.49–5.73, P = 0.02) . In a case–control study of 132 children with active moderate‐to‐severe AD, an association with central obesity and increased systolic blood pressure was reported .…”

Section: Discussionmentioning

confidence: 99%

Atopic dermatitis and the metabolic syndrome: a cross‐sectional study of 116 816 patients

Shalom

Dreiher

Kridin

et al. 2019

Acad Dermatol Venereol

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Background Data regarding the association between atopic dermatitis (AD) and the metabolic syndrome are controversial. Objective To evaluate the prevalence of the metabolic syndrome and its components in a large group of patients with AD compared to a matched reference group. Methods A cross‐sectional study of AD patients diagnosed by a dermatologist between 1998 and 2016, and a matched comparison group was performed. We analysed the association between AD and metabolic syndrome, its components and possible complications for the entire study population, adults (age > 18) and adults with moderate‐to‐severe AD. Results The study included 116 816 patients with AD and 116 812 comparison enrollees. AD in the entire group of patients and in the adult patients was associated with a higher prevalence of dyslipidaemia and a lower prevalence of diabetes and metabolic syndrome. Moderate and severe AD were associated, respectively, with higher prevalence rates of the metabolic syndrome (17.0% vs. 9.4%), its components (obesity: 22.2% vs. 18.6%; diabetes: 15.9% vs. 9.2%; hypertension 27.9% vs. 15.3%; dyslipidaemia 47.1% vs. 28.5%, all P values < 0.001) and cardiovascular morbidity (all P values < 0.001). Multivariate analysis demonstrated a significant overrepresentation of the metabolic syndrome in moderate‐to‐severe AD (P = 0.04). Conclusions Severely affected patients with AD may have one or more undiagnosed components of metabolic syndrome.

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Association Between Metabolic Syndrome and Atopic Dermatitis in Korean Adults

Cited by 31 publications

References 31 publications

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review

Atopic dermatitis and the metabolic syndrome: a cross‐sectional study of 116 816 patients

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