Association between metformin prescription and growth rates of abdominal aortic aneurysms

Golledge, Jonathan; Moxon, Joseph V.; Pinchbeck, Jenna; Anderson, G.; Rowbotham, Sophie E.; Jenkins, Jason; Bourke, Michael; Bourke, Bernie; Dear, Anthony E.; Buckenham, T.M.; Jones, Rhondda; Norman, Paul

doi:10.1002/bjs.10587

Cited by 103 publications

(55 citation statements)

References 36 publications

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“… 114 The negative association between metformin use and AAA enlargement and growth was confirmed in other studies. 115 , 116 No significant association was found between metformin use and the risk of rupture. 117 …”

Section: Effects Of Antidiabetic Treatmentsmentioning

confidence: 99%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

135

102

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Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only curative treatment available relies on surgical approaches; drug-based therapies are lacking, highlighting an unmet need for clinical practice. Abdominal aortic aneurysm (AAA) is frequently associated with atherosclerosis and cardiovascular risk factors including male sex, age, smoking, hypertension, and dyslipidaemia. Thoracic aortic aneurysm (TAA) is more often linked to genetic disorders of the extracellular matrix and the contractile apparatus but also share similar cardiovascular risk factors. Intriguingly, a large body of evidence points to an inverse association between diabetes and both AAA and TAA. A better understanding of the mechanisms underlying the negative association between diabetes and aortic aneurysm could help the development of innovative diagnostic and therapeutic approaches to tackle the disease. Here, we summarize current knowledge on the relationship between glycaemic parameters, diabetes, and the development of aortic aneurysm. Cellular and molecular pathways that underlie the protective effect of diabetes itself and its treatment are reviewed and discussed, along with their potential implications for clinical translation.

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Section: Effects Of Antidiabetic Treatmentsmentioning

confidence: 99%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

135

102

View full text Add to dashboard Cite

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“…Review of large surveillance cohorts also suggest a lower expansion rate in patients with diabetes, 8 most recently implicating the role of metformin. 9 Studies continue to be performed on experimental animal models of AAA, and multiple reviews to date continue…”

mentioning

confidence: 99%

Abdominal aortic aneurysm: An update

Chuen¹,

Theivendran²

2018

Aust J Gen Pract

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THE TREATMENT OF abdominal aortic aneurysm (AAA) has progressed significantly from the early days of open aneurysmorrhaphy and cellophane wrapping. The experiences of Albert Einstein and Rudolph Nissen now exist only in the annals of history, and the staple management of AAA disease includes targeted screening studies, patient education on detection, risk factor and medical management, screening for associated conditions, monitoring and surveillance until surgical treatment is warranted, and open repair or endovascular surgery followed by targeted postoperative surveillance. This article outlines current medical and surgical treatment strategies, for the appreciation of practitioners managing patients with AAA. It is assumed that readers are familiar with the basic concepts described in our previous papers on aortic and non-aortic aneurysms. 1,2

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“…This study demonstrates additionally, for the first time in a population-based study, that metformin prescription is associated with an additional reduction in AAA enlargement rate beyond that associated with the presence of diabetes itself. 5,6…”

Section: Discussionmentioning

confidence: 99%