Association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a Korean population

Yim, Jae Joon; Kim, Hee Jung; Kwon, O Jung; Koh, Won Jung

doi:10.1016/j.humimm.2008.06.003

Cited by 47 publications

(28 citation statements)

References 33 publications

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“…We found information on clinical signs for 689 patients and radiographic data for 1,044 patients (10,12,(14)(15)(16)20,21,(23)(24)(25)(27)(28)(29)(30)33). Most patients with pulmonary NTM infections were male (543/689).…”

Section: Clinical Signs and Radiographic Featuresmentioning

confidence: 99%

Nontuberculous Mycobacteria in Respiratory Tract Infections, Eastern Asia

Simons¹,

Ingen²,

Hsueh³

et al. 2011

Emerg. Infect. Dis.

115

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Section: Clinical Signs and Radiographic Featuresmentioning

confidence: 99%

Nontuberculous Mycobacteria in Respiratory Tract Infections, Eastern Asia

Simons¹,

Ingen²,

Hsueh³

et al. 2011

Emerg. Infect. Dis.

115

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“…However, host genetic factors for MAC infection have not been extensively studied, and only a few reports have demonstrated an association with genetic polymorphisms within HLA [7][8][9], SLC11A1 [10,11], MICA [12], and TLR2 [13].…”

Section: Introductionmentioning

confidence: 99%

Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex infection

et al. 2012

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“…A single nucleotide polymorphism in TLR2 has been linked to NTM lung diseases [2], and IFN-γ and IL-10 secretions have been reported to be suppressed among patients with NTM lung disease [3]. Furthermore, patients with NTM lung disease tend to be taller and leaner on average, with relatively high frequencies of scoliosis, pectus excavatum, and mitral valve prolapse [4].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea

Lee

Choi

et al. 2013

BMC Infect Dis

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BackgroundThis study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients.MethodsWe prospectively recruited patients between 20 and 80 years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients.ResultsA total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients.ConclusionsSignificant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE.Trial registration informationClinicalTrials.gov Registration number; NCT01616745

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Association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a Korean population

Cited by 47 publications

References 33 publications

Nontuberculous Mycobacteria in Respiratory Tract Infections, Eastern Asia

Nontuberculous Mycobacteria in Respiratory Tract Infections, Eastern Asia

Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex infection

Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea

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