Association Between Migraine and the G1246A Polymorphism in the Hypocretin Receptor 2 Gene

Schürks, Markus; Limmroth, Volker; Geissler, Ingrid; Tessmann, Grietje; Savidou, Irini; Engelbergs, Jörg; Kurth, Tobias; Diener, Hans‐Christoph; Rosskopf, Dieter

doi:10.1111/j.1526-4610.2007.00863.x

Cited by 17 publications

(9 citation statements)

References 29 publications

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“…This association was confirmed by a large study performed in Germany, showing that homozygous carriers of the G allele had a twofold increase in risk for the disease [15], but was not replicated in a complex dataset of CH patients of Danish, Swedish, and British origin [16]. Conversely, analyzing the same polymorphism in migraine, no statistical difference was found between cases and controls [17] and the same results were obtained by an independent group [18]. Thereby, in order to deepen the analysis of hypocretin system in migraine pathogenesis, we hypothesized that HCRTR1 gene polymorphisms would modify the occurrence and the clinical features of migraine patients.…”

Section: Introductionmentioning

confidence: 82%

Evidence for an association between migraine and the hypocretin receptor 1 gene

et al. 2011

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The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case–control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypic and allelic frequencies of the rs2271933 non-synonymous polymorphism resulted different (χ2 = 9.872, p = 0.007; χ2 = 8.108, p = 0.004) between migraineurs and controls. The carriage of the A allele was associated with an increased migraine risk (OR 1.42, 95% CI 1.11–1.81). When we divided the migraine patients into different subgroups, the difference reached the level of statistical significance only in migraine without aura. The different genotypes had no significant effect on the examined clinical characteristics of the disease. In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine.

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Section: Introductionmentioning

confidence: 82%

Evidence for an association between migraine and the hypocretin receptor 1 gene

et al. 2011

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“…Some polymorphisms, including the well‐known G1246A, of the orexin2‐receptor have been linked to cluster headache in the majority of studies 15‐17 but not in all studies 18 and not to treatment response in cluster headache 19 . Studies on the same polymorphism in migraine did not reveal a significant association 20,21 . Another gene involved in circadian rhythmicity, the CLOCK gene with its T3111C polymorphism, has also not been linked to cluster headache 22 …”

Section: The Anatomy Of the Sleeping And Of The Headache Brainmentioning

confidence: 99%

Sleep and Headache: The Biological Basis

Evers

2010

Headache

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Sleep and trigeminal pain processing share several common pathways with respect to neurotransmission and functions of distinct brain areas. In this review, the role of the most important brain stem and midbrain regions for this link is discussed. The central structure involved in both headache and sleep is the hypothalamus in which the orexinergic neurons originate. These neurons project to the periaqueductal grey and are probably the anatomic and physiological link between headache and sleep. Another relevant system for this interrelationship is the melatonin metabolism. However, basic research in this field is still very preliminary and a holistic hypothesis on how sleep physiology impacts headache and vice versa is still missing.

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“…Studies in CH patients prompted two independent research groups to evaluate the association of the G1246A polymorphisms in the HCRTR2 gene with migraine. Both studies found no association between this polymorphism and migraine or its clinical subtypes [88,89]. Recently, we performed a genetic case–control study to investigate whether genetic variants in the HCRTR1 gene could modify the occurrence and the clinical features of migraine.…”

Section: Reviewmentioning

confidence: 99%

Genes and primary headaches: discovering new potential therapeutic targets

et al. 2013

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Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors. Genetic association studies have highlighted a potential role in the etiopathogenesis of these disorders for several genes related to vascular, neuronal and neuroendocrine functions. A potential role as a therapeutic target is now emerging for some of these genes. The main purpose of this review is to describe new advances in our knowledge regarding the role of MTHFR, KCNK18, TRPV1, TRPV3 and HCRTR genes in primary headache disorders. Involvement of these genes in primary headaches, as well as their potential role in the therapy of these disorders, will be discussed.

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Association Between Migraine and the G1246A Polymorphism in the Hypocretin Receptor 2 Gene

Abstract: Our study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache.

Cited by 17 publications

References 29 publications

Evidence for an association between migraine and the hypocretin receptor 1 gene

Evidence for an association between migraine and the hypocretin receptor 1 gene

Sleep and Headache: The Biological Basis

Genes and primary headaches: discovering new potential therapeutic targets

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