Association between miR-124-1 rs531564 polymorphism and risk of cancer: an updated meta-analysis of case-control studies

Moazeni‐Roodi, Abdolkarim; Hashemi, Mohammad

doi:10.17179/excli2018-1419

Cited by 8 publications

(4 citation statements)

References 34 publications

(54 reference statements)

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“…Rs531564 (G > C) is a functional SNP in pri-miRNA-124, which affects the expression of the mature miRNA-124 [ 101 ]. Qi et al (2012) found that the presence of the G allele changed the formation of a ring-shaped structure in the secondary structure of the pri-miRNA, and the carriers of the G allele had an increased amount of tumor suppressor miRNA-124 [ 102 ].…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

“…However, they performed in silico prediction of SNP on miRNA secondary folding and stability, and no significant difference was found in the foldings and their free energies in pre-miR-124-1 carrying wild and mutant allele of rs531564. These different, in terms of their results, studies were included in a meta-analysis, which confirmed that rs531564 G allele was significantly associated with protection against CRC but only under the recessive model (GG vs. CG + CC) [ 101 ].…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

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Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.

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Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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“…Approximately 10%–20% of individuals with a persistent cervical HPV infection showed a higher risk of CIN2/3 lesion ( 40 ). The evasion mechanisms of HPV from the immune cell recognition and downregulation of innate and adaptive immune responses lead to the establishment and persistence of HPV infection ( 25 , 41 ). The oncoproteins E5, E6, and E7 play a crucial role in the malignant transformation of HPV-related lesions.…”

Section: Hpv and Etiology Of Human Cancersmentioning

confidence: 99%

An Update on Human Papilloma Virus Vaccines: History, Types, Protection, and Efficacy

et al. 2022

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Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. Early prevention with HPV vaccination is a safe and effective method against this disease. HPV vaccines provided more protection against several oncogenic HPV strains. Three prophylactic HPV vaccines have been approved to target high-risk HPV types and protect against HPV-related disorders. These existing vaccines are based on the recombinant DNA technology and purified L1 protein that is assembled to form HPV empty shells. The prophylactic vaccines are highly immunogenic and can induce production of specific neutralizing antibodies. However, therapeutic vaccines are different from these prophylactic vaccines. They induced cell-mediated immunity against transformed cells, instead of neutralizing antibodies. The second generation of prophylactic HPV vaccines, made from alternative viral components using cost-effective production strategies, is undergoing clinical evaluation. The purpose of this review is to provide a complete and up-to-date review of the types of HPV vaccines and the efficiency of each of them for readers.

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“…A reported tumor suppressor, miR-124, functions in the development of various malignancies such as gastric cancer, cervical cancer, hematological malignancies and hepatocellular carcinoma [ 4 ]. It has been confirmed that its SNP, rs531564, was associated with susceptibility of esophageal adenocarcinoma, bladder cancer and gastric cancer [ 5 ]. In this study, we hypothesized that rs531564 could be used as an indicator for the prognosis of SCI as it interferes with the singling pathway of miR-124 and BIM.…”

mentioning

confidence: 99%

A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)

Zhang

Sui

Xia³

2022

Arch Med Sci

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IntroductionIn this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways.Material and methodsFive hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression.ResultsBy luciferase assays, we validated Bcl-2-like protein 11 (BIM) as a target gene of miR-124 with a negative regulatory relationship between them. We also observed that miR-124 suppressed cell viability and accelerated cell apoptosis.Conclusionsrs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.

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Association between miR-124-1 rs531564 polymorphism and risk of cancer: an updated meta-analysis of case-control studies

Cited by 8 publications

References 34 publications

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

An Update on Human Papilloma Virus Vaccines: History, Types, Protection, and Efficacy

A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)

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