Association between miR-146a rs2910164 polymorphism and autoimmune diseases susceptibility: A meta-analysis

Chen, Hui Fang; Hu, Ting; Zheng, Xue; Li, Mei Qing; Luo, Min; Yao, Yue; Chen, Qing; Yu, Shou yi

doi:10.1016/j.gene.2013.03.073

Cited by 28 publications

(25 citation statements)

References 35 publications

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“…Several studies have examined the association between the miR-146a rs2910164 polymorphism and autoimmune diseases, including RA [8], SLE [8,9] and MS [19]. Although previous studies have suggested that many autoimmune diseases share common predisposing factors, the results are inconsistent [26]. In this hospital-based, case-control study, the allele and genotype frequencies of the miR-146a polymorphisms did not differ significantly between the MS patients and healthy controls; this result is consistent with Fenoglio's previous report [19].…”

Section: Discussionmentioning

confidence: 99%

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

Wang

et al. 2015

Cell Physiol Biochem

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Background: miR-146a polymorphisms have been involved in susceptibility to multiple diseases. The aim of the present study was to analyze the potential association between two functional miR-146a polymorphisms (rs2910164 and rs57095329) and multiple sclerosis (MS) in the Han Chinese population. Methods: A cohort of 525 patients and 568 healthy controls were genotyped to detect the two polymorphisms by SNaPshot. Results: No significant differences were detected in the distribution of the two miR-146a polymorphisms between the patients and controls (P > 0.05). However, stratification by gender showed a statistically significant difference in the frequency of the genotype rs2910164 between MS patients and control females (P=0.009). Further stratification analysis by subgroup revealed that the miR-146a rs2910164 C allele conferred a higher risk of developing relapsing-remitting MS (RRMS) (P=0.018). In addition, the rs2910164 C allele was significantly associated with increased expression of miR-146a in patients with RRMS (P=0.025). Moreover, patients with the rs2910164 C allele released more TNF-α and IFN-γ, but not IL-1β, compared with individuals carrying the homozygous GG genotype (P < 0.05). Conclusions: Our results provide evidence that rs2910164 may play a role in MS susceptibility in females. The rs2910164 G>C variation may affect the expression of miR-146a and the release of proinflammatory cytokines.

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Section: Discussionmentioning

confidence: 99%

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

Wang

et al. 2015

Cell Physiol Biochem

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“…The odds ratio (OR) and its 95% CI were used to assess the strength of the association between the analyzed polymorphisms and the disease. In meta-analyses, heterogeneity between all the analyses was determined by I 2 , and data with high heterogeneity ( I 2 >50%) were processed using a random-effects model or a fixed-effects model (24). All the statistical analyses were carried out using the GraphPad Prism 5 Software (www.graphpad.com), and the Review Manager 5.2 Software (Copenhagen, Denmark) was used for the meta-analyses.…”

Section: Methodsmentioning

confidence: 99%

Are pre-miR-146a and PTTG1 associated with papillary thyroid cancer?

Marino¹,

Cirello²,

Gnarini³

et al. 2013

Endocrine Connections

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Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with a steadily increasing incidence in the last few decades worldwide. The predisposition to developing this carcinoma by the heterozygous state of rs2910164 within the precursor of the miR-146a has been reported, but recently not confirmed. Interestingly, on the same chromosome, almost 50 kb separate the pre-miR-146a from the pituitary tumor-transforming gene 1 (PTTG1), a proto-oncogene involved in several tumors, including thyroid cancers. In this study, we analyzed, using a case–control design, the genetic association between PTC and the genomic region encompassing pre-miR-146a rs2910164 and PTTG1 rs1862391 and rs2910202. We enrolled 307 affected patients and 206 healthy controls. The possible presence of thyroid nodules in controls was excluded by ultrasonography. All the cases were submitted to single-nucleotide polymorphism (SNP) genotyping of pre-miR-146a and PTTG1, and risk association analyses were carried out. The genotypic and allelic frequencies of pre-miR-146a rs2910164 were not statistically different in the patients and controls, and this SNP was not in linkage disequilibrium with the investigated PTTG1 SNPs. Consistently, meta-analyses, the first including all the affected cases published to date, did not confirm the previously reported association of the heterozygous CG genotype with PTC. The PTTG1 SNPs exhibited the same allelic frequency in the patients and controls and were not associated with the disease. In conclusion, in a well-selected Italian population, neither pre-miR-146a rs2910164 nor PTTG1 rs1862391 and rs2910202 were found to be associated with the risk of developing PTC.

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“…In addition to the homozygosity of C allele's protective role, the dominant model (CC + CG vs. GG) also shows that having at least one C allele has a protective effect in BD. Confoundly, in some studies, the CG genotype (Chen et al, 2013) and combined CG + GG (Zhang et al, 2014) genotypes are shown to be risk factors for autoimmune diseases in Asians and for psoriasis, respectively. When we evaluated rs28362491 and rs2910164 polymorphisms together, we did not find any significant differences between BD patients and the control groups.…”

Section: Discussionmentioning

confidence: 99%

Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

Oner

Yenmiş

Tombultürk

et al. 2015

Genetic Testing and Molecular Biomarkers

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MiRNAs and NFKB1 are well-known immune response and inflammation regulators. MiRNA gene polymorphisms may affect miRNA biogenesis and function and, may thus, lead to changes in the expression of hundreds of genes such as NFKB1. The aim of this study was to investigate the association of Behcet's disease (BD) with NFKB1 rs28362491, pre-miRNA-146a rs2910164, and pre-miRNA-499 rs3746444 polymorphisms, as well as the analysis of their single and combined effects on its susceptibility in a Turkish population. These polymorphisms were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism method in 100 BD patients and 145 healthy control subjects. The results were analyzed statistically using Pearson chi-square (χ(2)) test and Fisher's exact test (two sided). According to genotype analysis, the frequencies of ins/ins genotype and ins allele of rs28362491 were considerably higher in BD patients. Also, miRNA-499 rs3746444 homozygous (TT) genotypes exibited a significantly higher risk in patients with BD (odds ratios [OR]=3.0, 95% confidence intervals [95% CI]=1.284-7.007, p=0.017). Moreover, the frequency of T allele of rs3746444 was a risk factor for BD (OR=1.562, 95% CI=1.087-2.24, p=0.015). In addition, significant differences were found between the groups concerning miRNA-146a rs2910164 polymorphism. Homozygous CC genotype and C allele of rs2910164 polymorphism were found to be protective factors against BD. The results of the combined genotype analysis showed no notable differences between the multiple comparisons of rs28362491-rs2910164 and of rs28362491-rs3746444 in patients and control groups. Our data demonstrate that homozygous CC genotype and C allele of rs2910164 polymorphism are protective factors against BD, but rs3746444 and rs28362491 polymorphisms in miRNA-499 and in NFKB1 promoter are involved in the genetic susceptibility of BD. In addition, TT and ins/ins genotypes may influence certain proinflammatory cytokines and, may thus, play a role in the pathogenesis of BD.

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Association between miR-146a rs2910164 polymorphism and autoimmune diseases susceptibility: A meta-analysis

Cited by 28 publications

References 35 publications

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population

Are pre-miR-146a and PTTG1 associated with papillary thyroid cancer?

Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

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