Association between monocyte to high-density lipoprotein ratio and coronary heart disease in US adults in the National Health and Nutrition Examination Surveys 2009–2018

Abstract

Background Monocyte to high-density lipoprotein ratio (MHR) is associated with coronary heart disease (CHD) events. The purpose of this study was to analyze the correlation between MHR and CHD in American adults from 2009 to 2018 in the National Health and Nutrition Examination Surveys (NHANES) database. Methods A total of 25 862 persons in the NHANES from 2009 to 2018 were included in the cross-sectional analysis. The independent variable was MHR and the outcome variable was CHD. MHR was obtained by dividing the number of monocytes by the high-density lipoprotein concentration, and whether it is CHD is obtained through a questionnaire. Univariate analysis, stratified analysis, and a multivariate linear regression model were used to study the correlation between MHR and CHD. Results In each multivariate linear regression model, MHR was positively correlated with CHD, and this positive correlation was stable in both men and women [man odds ratio (OR): 1.54; 95% confidence interval (CI), 1.17–2.03; woman OR: 2.21; 95% CI, 1.40–3.50]. Our results show that the association between MHR and CHD was significant until MHR was less than 0.6 (OR: 7.2; 95% CI, 4.0–13.0); however, in cases where MHR was greater than 0.6, the results were negative but not significantly different (OR: 0.6; 95% CI, 0.3–1.2). Conclusion MHR has a clear association with CHD. Our prediction model and validation model show that MHR is highly predictive and robust as a predictor of CHD, therefore it can play an important role in the prediction of CHD.

Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009–2018

“…Our subgroup analysis showed significant gender differences in the relationship between inflammatory markers and hypertension risk. For example, sedentary women had the highest risk of hypertension from the MHR marker (OR = 2.50), aligning with similar gender disparities seen with MHR in coronary heart disease 30 . Analysis of 105,239 participants indicated that prolonged sitting elevates metabolic syndrome risk more in women, 28 suggesting gender‐specific physiological differences.…”

“…For example, sedentary women had the highest risk of hypertension from the MHR marker (OR = 2.50), aligning with similar gender disparities seen with MHR in coronary heart disease. 30 Analysis of 105,239 participants indicated that prolonged sitting elevates metabolic syndrome risk more in women, 28 suggesting gender-specific physiological differences. The obese population exhibited the highest risk of hypertension, as shown by inflammatory markers (MHR's OR = 2.8, SIRI's OR = 1.53, lnSII's OR = 1.22), aligning with previous studies linking higher BMI to increased hypertension risk.…”

Association between monocyte-to-high-density lipoprotein-cholesterol ratio and gallstones in U.S. adults: findings from the National Health and Nutrition Examination Survey 2017–2020

“…For example, a study that included over 30,000 participants demonstrated that MHR was substantially associated with cardiovascular mortality in the American population [27]. Another study investigated the association between MHR and coronary heart disease and found a positive association between MHR and the prevalence of coronary heart disease at an MHR < 0.6 [28]. Moreover, numerous studies have demonstrated that MHR is not only linked to cardiovascular disease, but may also be associated with several other diseases.…”

Which Biomarker(s) Augment the Diagnostic Value of the Positive Exercise Electrocardiography Test: Systemic Inflammatory Index, Plasma Atherogenic Index, or Monocyte/HDL-C Ratio?

“…In one previous study, it was shown that a high MHR value was a risk factor for atherosclerosis and could be evaluated as a predictor of atherosclerosis development [34]. According to the National Health and Nutrition Examination Survey (NHANES) data, a positive correlation and clear relationship were determined between MHR and CAD in a study of 25,862 American adults between 2009 and 2018 [35]. Together with studies showing the presence of atherosclerosis, there are also studies related to disease severity.…”