Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis

Li, Li; Yu, Hao; Zhang, Huan; Wang, Jiangjun; Hu, Wei

doi:10.1007/s00059-021-05087-2

Cited by 4 publications

(8 citation statements)

References 31 publications

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“…The MTHFR rs1801133 polymorphism was risk factor for carotid artery arteriosclerosis [ 32 ]. The MTHFR rs1801133 polymorphism was associated with increased risk of CAD in different populations [ 42 – 46 ]. In mechanism, vascular 5-methyl-tetrahydrofolate (5-MTHF) is a key regulator of human vascular endothelial nitric oxide synthase coupling and nitric oxide bioavailability, and MTHFR rs1801133 polymorphism plays an important role in the regulation of vascular redox status by affecting the expression of vascular 5-MTHF [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

ALDH2 rs671 and MTHFR rs1801133 polymorphisms are risk factors for arteriosclerosis in multiple arteries

Cai

et al. 2023

BMC Cardiovasc Disord

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Background Arteriosclerosis in multiple arteries has long been associated with heightened cardiovascular risk. Acetaldehyde dehydrogenase 2 (ALDH2) and methylenetetrahydrofolate reductase (MTHFR) play an important role in the pathogenesis of arteriosclerosis by participating in the oxidation and reduction reactions in vascular endothelial cells. The purpose was to investigate the relationship of ALDH2 and MTHFR gene polymorphisms with arteriosclerosis in multiple arteries. Methods 410 patients with arteriosclerosis in single artery and 472 patients with arteriosclerosis in multiple arteries were included. The relationship between ALDH2 rs671 and MTHFR rs1801133 polymorphisms and arteriosclerosis in single artery and arteriosclerosis in multiple arteries was analyzed. Results The proportion of ALDH2 rs671 A allele (35.6% vs. 30.9%, P = 0.038) and MTHFR rs1801133 T allele (32.6% vs. 27.1%, P = 0.012) in patients with arteriosclerosis in multiple arteries was significantly higher than that in arteriosclerosis in single artery, respectively. The proportion of history of alcohol consumption in patients with ALDH2 rs671 G/G genotype was higher than those in ALDH2 rs671 G/A genotype and A/A genotype (P < 0.001). The results of logistic regression analysis indicated that ALDH2 rs671 A/A genotype (A/A vs. G/G: OR 1.996, 95% CI: 1.258–3.166, P = 0.003) and MTHFR rs1801133 T/T genotype (T/T vs. C/C: OR 1.943, 95% CI: 1.179–3.203, P = 0.009) may be independent risk factors for arteriosclerosis in multiple arteries (adjusted for age, sex, smoking, drinking, hypertension, and diabetes). Conclusions ALDH2 rs671 A/A and MTHFR rs1801133 T/T genotypes may be independent risk factors for arteriosclerosis in multiple arteries.

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Section: Discussionmentioning

confidence: 99%

ALDH2 rs671 and MTHFR rs1801133 polymorphisms are risk factors for arteriosclerosis in multiple arteries

Cai

et al. 2023

BMC Cardiovasc Disord

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“… 23 included 156,000 individuals and did not detect a positive correlation between rs1801133 and CAD, consistent with a large‐scale clinical trial conducted by Lewis et al.. 24 Since the present results were controversial, 22 , 23 , 24 Li et al. 25 performed a meta‐analysis (6117 patients with CAD and 5984 controls) to clarify or confirm whether rs1801133 affected the risk of CAD in Chinese individuals in the light of evidence‐based medicine. Their results showed that rs1801133 T allele (odds ratios [OR] = 1.65, 95% confidence intervals [CI] = 1.43–1.89, p < 0.0001) and TT genotype (OR = 1.48, 95% CI = 1.29–1.70, p < 0.0001) significantly increased the risk of CAD in Chinese individuals.…”

Section: Introductionmentioning

confidence: 93%

“…Their results showed that rs1801133 T allele (odds ratios [OR] = 1.65, 95% confidence intervals [CI] = 1.43–1.89, p < 0.0001) and TT genotype (OR = 1.48, 95% CI = 1.29–1.70, p < 0.0001) significantly increased the risk of CAD in Chinese individuals. 25 However, the specific mechanism is not clear. Here, this study is conducted to investigate the impacts of rs1801133 on cardiometabolic parameters, to provide some clues or references for the clarification of underlying mechanism involved.…”

Section: Introductionmentioning

confidence: 99%

Homocysteine concentration in coronary artery disease and severity of coronary lesions

Luo,

Tang,

Huang

et al. 2024

J Cellular Molecular Medi

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Our previous study reckons that the impact of the rs1801133 variant of 5,10‐methylenetetrahydrofolate reductase (MTHFR) on coronary artery disease (CAD) is possibly mediated by cardiometabolic disorder. This study is performed to verify this hypothesis. Four hundred and thirty CAD patients and 216 CAD‐free individuals were enrolled in this case–control study. The rs1801133 variant was genotyped by PCR‐RFLP. Severity of coronary lesions was evaluated by number of stenotic coronary vessels and extent of coronary stenosis. The rs1801133 T allele significantly increased homocysteine levels in patients with CAD and CAD‐free individuals. Individuals with the T allele of rs1801133 had an increased risk of developing CAD. In contrast, individuals with the TT genotype of rs1801133 were at high risk of multiple vessel lesions. The carriers of CT genotype had higher levels of systolic blood pressure (SBP), low‐density lipoprotein cholesterol (LDL‐C), and high‐sensitivity C‐reactive protein (hs‐CRP), and lower levels of apolipoprotein A1 (APOA1) than those with CC genotype in male patients with CAD. The receiver operating characteristic (ROC) curve and precision‐recall (PR) curve indicated that hyperhomocysteinemia was sensitive to predict the severity of CAD. Multivariate logistic regression revealed that homocysteine, rs1801133, age, smoking, weight, body mass index (BMI), lipoprotein(a) [Lp(a)], and hs‐CRP were independent risk factors for CAD. The increased risk of CAD and severity of coronary lesions associated with rs1801133 in the Chinese Han population were attributed, at least partly, to high homocysteine levels. Hyperhomocysteinemia had a high predictive value for severe CAD or multiple vessel lesions.

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“…High homocysteine levels are associated with an increased risk of myocardial infarction. A clear association between the MTHFR C677T polymorphism and the risk of CAD has been demonstrated in the Chinese population 8 . It is also expressed that homozygous TT variant of MTHFR gene in Eastern Black Sea Turks is a risk factor for MI patients 9 .…”

Section: Introductionmentioning

confidence: 97%

Thrombophilic gene variants in patients with coronary artery disease and myocardial infarction

YILDIRIM

2023

CMJ

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Background and aim: Coronary artery disease (CAD) and myocardial infarction (MI) are cardiovascular diseases that occur due to atherosclerosis (plaque formation) or atherosclerotic obstruction of the coronary arteries. Their genetic basis has been under investigation for a long time, and common variant studies link different genetic loci with these diseases. In this study, we investigated the possible association of coronary artery disease and myocardial infarction with thrombophilic gene variants, including MTHFR C677T and A1298C, Beta fibrinogen -455G/A, Factor XIIIV34L and PAI-1 4G/5G single nucleotide polymorphisms (SNPs). Methods: A total of 128 people (64 patients and 64 controls) were included in the study. Genomic DNA was isolated using the EZ1 blood mini kit. The DNA was amplified and PCR was performed using the PyroMark PCR Kit (Qiagen, Germany). Pyrosequencing reaction was completed by processing with PyroMark Q24 instrument. Results: We found that the PAI-1 4G/5G polymorphism and the 4G allele were significantly associated with coronary artery disease and myocardial infarction (P= 0.01). Although mutant variants were higher in patients, no statistically significant difference was observed between the patient and control groups in terms of FXIII, Beta-fibrinogen and MTHFR variants. Conclusions: It is clear that the PAI-1 4G allele and the 4G/4G genotype have a significant contribution to the development of coronary artery disease and ultimately myocardial infarction. Prophylactic treatment should be considered in patients with this variant.

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Association between MTHFR C677T polymorphism and risk of coronary artery disease in the Chinese population: meta-analysis

Cited by 4 publications

References 31 publications

ALDH2 rs671 and MTHFR rs1801133 polymorphisms are risk factors for arteriosclerosis in multiple arteries

ALDH2 rs671 and MTHFR rs1801133 polymorphisms are risk factors for arteriosclerosis in multiple arteries

Homocysteine concentration in coronary artery disease and severity of coronary lesions

Thrombophilic gene variants in patients with coronary artery disease and myocardial infarction

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