Association between multiple sclerosis and prostate cancer risk: A systematic review and meta‑analysis

Hu, Zhiya; Fu, Yongxin; Wang, Jiawu; Li, Yisen; Jiang, Qing

doi:10.3892/ol.2023.13669

Cited by 3 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For central system immune diseases, studies on systemic sclerosis and prostate cancer are ambiguous. However, a newly published meta-analysis that pooled the results of all studies showed no association between systemic sclerosis and prostate cancer [39]. But it is important to note that testosterone levels are signi cantly reduced in people with MS, which may have implications for the development of prostate cancer [40].…”

Section: Discussionmentioning

confidence: 99%

Association between autoimmune disorders and prostate cancer: a Mendelian Randomization Study

Chen,

Xiong,

Luo

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Although many epidemiological studies or meta-analyses have reported an association between autoimmune disorders and prostate cancer, no studies have reported a clear causal relationship and the direction of the association. The purpose of our research was to explore the potential causal relationship between autoimmune disorders and prostate cancer through mendelian randomization study(MR). Method: We retrieve literature through the pubmed using key words of "Autoimmune disorder" AND "cancer", and find that more than ten autoimmune disorders and cancer are potentially related. We continue to use the keywords of “autoimmune disorder” AND “prostate cancer” to find more clues on the correlation between prostate cancer and autoimmune disease. According to the above literature support, we selected 16 common autoimmune disorders that may be associated with prostate cancer. We extracted and selected disease-related single nucleotide polymorphisms (SNPs) from the largest and public genome-wide association study (GWAS) summary data. Inverse variance weighted (IVW) method was applied as our primary analyses for the two-sample Mendelian randomization and multivariate mendelian randomization analysis to estimate the OR value and 95% confidence interval. In addition, we conducted other two analyses to verify the reliability of the conclusion: weighted median method and MR-Egger method. We further verified the robustness of the conclusions by a series of sensitivity analyses. Results: The autoimmune diseases we selected included rheumatoid arthritis, ankylosing spondylitis, coxarthrosis, gonarthrosis, Crohn's disease, ulcerative colitis, irritable bowel syndrome, celiac disease, primary sclerosing cholangitis, asthma, type I diabetes, systemic lupus erythematosus, multiple sclerosis, autoimmune hyperthyroidism, psoriatic arthritis, and polymyalgia rheumatica. The results of IVW methods suggest that six immune diseases have been associated with the development of prostate cancer. Three diseases that may be significantly associated with higher risk of prostate cancer are rheumatoid arthritis (OR: 1.03, 95%CI,1.01-1.05, p=0.001), coxarthrosis (OR: 1.17, 95%CI,1.08-1.26, p < 0.001), and gonarthrosis (OR: 1.17, 95%CI,1.05-1.3, p=0.008). Three possible protective factors for prostate cancer are primary sclerosing cholangitis (OR: 0.97, 95%CI,0.95-0.99, p=0.001), autoimmune hyperthyroidism (OR: 0.97, 95%CI,0.94-0.99, p=0.011), and psoriatic arthritis (OR: 0.97, 95%CI,0.95-0.99, p=0.001). Multivariate Mendelian randomization found no association between Crohn's disease or ulcerative colitis and prostate cancer. Horizontal pleiotropy was not found in MR-Egger intercepts. Conclusion: Our findings provide genetic predictive evidence of an association between autoimmune disorders and prostate cancer, and these findings have important implications for screening and management in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between autoimmune disorders and prostate cancer: a Mendelian Randomization Study

Chen,

Xiong,

Luo

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Association between autoimmunity-related disorders and prostate cancer: A Mendelian randomization study

Chen,

Wang,

Xiong

et al. 2024

Cancer Pathogenesis and Therapy

View full text Add to dashboard Cite

Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses

Cui,

Zhang,

Zhang

et al. 2024

PLoS Med

View full text Add to dashboard Cite

Background The incidence of prostate cancer is increasing in older males globally. Age, ethnicity, and family history are identified as the well-known risk factors for prostate cancer, but few modifiable factors have been firmly established. The objective of this study was to identify and evaluate various factors modifying the risk of prostate cancer reported in meta-analyses of prospective observational studies and mendelian randomization (MR) analyses. Methods and findings We searched PubMed, Embase, and Web of Science from the inception to January 10, 2022, updated on September 9, 2023, to identify meta-analyses and MR studies on prostate cancer. Eligibility criteria for meta-analyses were (1) meta-analyses including prospective observational studies or studies that declared outcome-free at baseline; (2) evaluating the factors of any category associated with prostate cancer incidence; and (3) providing effect estimates for further data synthesis. Similar criteria were applied to MR studies. Meta-analysis was repeated using the random-effects inverse-variance model with DerSimonian—Laird method. Quality assessment was then conducted for included meta-analyses using AMSTAR-2 tool and for MR studies using STROBE-MR and assumption evaluation. Subsequent evidence grading criteria for significant associations in meta-analyses contained sample size, P values and 95% confidence intervals, 95% prediction intervals, heterogeneity, and publication bias, assigning 4 evidence grades (convincing, highly suggestive, suggestive, or weak). Significant associations in MR studies were graded as robust, probable, suggestive, or insufficient considering P values and concordance of effect directions. Finally, 92 selected from 411 meta-analyses and 64 selected from 118 MR studies were included after excluding the overlapping and outdated studies which were published earlier and contained fewer participants or fewer instrument variables for the same exposure. In total, 123 observational associations (45 significant and 78 null) and 145 causal associations (55 significant and 90 null) were categorized into lifestyle; diet and nutrition; anthropometric indices; biomarkers; clinical variables, diseases, and treatments; and environmental factors. Concerning evidence grading on significant associations, there were 5 highly suggestive, 36 suggestive, and 4 weak associations in meta-analyses, and 10 robust, 24 probable, 4 suggestive, and 17 insufficient causal associations in MR studies. Twenty-six overlapping factors between meta-analyses and MR studies were identified, with consistent significant effects found for physical activity (PA) (occupational PA in meta: OR = 0.87, 95% CI: 0.80, 0.94; accelerator-measured PA in MR: OR = 0.49, 95% CI: 0.33, 0.72), height (meta: OR = 1.09, 95% CI: 1.06, 1.12; MR: OR = 1.07, 95% CI: 1.01, 1.15, for aggressive prostate cancer), and smoking (current smoking in meta: OR = 0.74, 95% CI: 0.68, 0.80; smoking initiation in MR: OR = 0.91, 95% CI: 0.86, 0.97). Methodological limitation is that the evidence grading criteria could be expanded by considering more indices. Conclusions In this large-scale study, we summarized the associations of various factors with prostate cancer risk and provided comparisons between observational associations by meta-analysis and genetically estimated causality by MR analyses. In the absence of convincing overlapping evidence based on the existing literature, no robust associations were identified, but some effects were observed for height, physical activity, and smoking.

show abstract

Association between multiple sclerosis and prostate cancer risk: A systematic review and meta‑analysis

Cited by 3 publications

References 36 publications

Association between autoimmune disorders and prostate cancer: a Mendelian Randomization Study

Association between autoimmune disorders and prostate cancer: a Mendelian Randomization Study

Association between autoimmunity-related disorders and prostate cancer: A Mendelian randomization study

Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses

Contact Info

Product

Resources

About