Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan

Koda, Masahide; Iwasaki, Motoki; Yamano, Yuko; Lu, Xi; Katoh, Takahiko

doi:10.1186/s12199-017-0681-0

Cited by 22 publications

(15 citation statements)

References 48 publications

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“…These enzymes metabolize polycyclic aromatic hydrocarbons, arylamines, and N-heterocyclics that are found in grilled food or meat cooked at high temperatures. These molecules can be carcinogenic and toxic when accumulated in the organism [41, 42]. Three independent studies found evidence of positive selection in CYP1A2 gene.…”

Section: Introductionmentioning

confidence: 99%

Is there adaptation in the human genome for taste perception and phase I biotransformation?

et al. 2019

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BackgroundDuring the modern human expansion, new environmental pressures may have driven adaptation, especially in genes related to the perception of ingested substances and their detoxification. Consequently, positive (adaptive) selection may have occurred in genes related to taste, and in those related to the CYP450 system due to its role in biotransformation of potentially toxic compounds. A total of 91 genes (taste receptors and CYP450 superfamily) have been studied using Hierarchical Boosting, a powerful combination of different selection tests, to detect signatures of recent positive selection in three continental human populations: Northern Europeans (CEU), East Asians (CHB) and Africans (YRI). Analyses have been refined with selection analyses of the 26 populations of 1000 Genomes Project Phase 3.ResultsGenes related to taste perception have not been positively selected in the three continental human populations. This finding suggests that, contrary to results of previous studies, different allele frequencies among populations in genes such as TAS2R38 and TAS2R16 are not due to positive selection but to genetic drift. CYP1 and CYP2 genes, also previously considered to be under positive selection, did not show signatures of selective sweeps. However, three genes belonging to the CYP450 system have been identified by the Hierarchical Boosting as positively selected: CYP3A4 and CYP3A43 in CEU, and CYP27A1 in CHB.ConclusionsNo main adaptive differences are found in known taste receptor genes among the three continental human populations studied. However, there are important genetic adaptations in the cytochrome P450 system related to the Out of Africa expansion of modern humans. We confirmed that CYP3A4 and CYP3A43 are under selection in CEU, and we report for the first time CYP27A1 to be under positive selection in CHB.Electronic supplementary materialThe online version of this article (10.1186/s12862-019-1366-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Is there adaptation in the human genome for taste perception and phase I biotransformation?

et al. 2019

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“…The NAT2 acetylated genotype has a large influence on cancer predisposition and may induce susceptibility to tumors arising from industrial and environmental aryl amines (Mitchell, 2019). To date, a limited number of studies have been published in Sudan concerning inter-individual and inter-ethnic differences in NAT2 allele frequencies, (Ali et al, 2019;Al-Yahyaee et al, 2007) but this is the first investigation into its genetic variations (481 C→T, 590 G→A, 803 A→G and 857G→A) and their association with CML susceptibility and progression (Kotila et al, 2019).…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia

Tebien

Khalil

Mills

et al. 2020

Asian Pac J Cancer Prev

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Objectives: The N-Acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in xenobiotic metabolism, which contributes to the detoxification of numerous cancer therapy-induced products. However, the NAT2 genotype/phenotype is not fully understood and few studies have reported its relationship with CML. The aim of this study was to determine whether its polymorphisms ( C481T, G590A, 803A>G and 857G>A ) have a role in chronic myeloid leukemia susceptibility (CML) in Sudanese population. Methods: We performed a case- control study. DNA from 200 CML patients and 100 controls was analyzed for the NAT2 polymorphisms using PCR-RFLP assay. Results: The study showed NAT2 polymorphisms 803AG are associated with CML protection by a factor of 2.3, (OR = 0.044, 95% CI: 0.020-0.095, p = 0. 000). The study indicated that the heterozygous (GA) and mutant (AA) variants of the G857A genotype also offer protection, (OR = 0.002, 95% CI: 0.002-0.019, p = 0. 000) and (OR = 0.018, 95% CI: 0.002-0.133, p = 0. 000), respectively. Conclusion: There was no significant difference in CML diagnosis among Sudanese cases with the 481C→T and 590G→A polymorphisms. But patients with the compound NAT2 genotypes 481CT/803 AG, 590AG/ 803AG, 590AG/ 803GG, 590AA/ 803AG and 590GG/ 803AG were found to have a reduced risk. The current study demonstrates that polymorphisms of NAT2 A803G and G857A might also act as protective factors against developing the disease.

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“…Of the 50 known P450 isoenzymes catalyzing drug metabolism, more than 20 P450 genes are functionally polymorphic, such as CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP1B1, and CYP1A2. The polymorphic P450s catalyze about 40% of the drug metabolism [119,135]. In addition, P450 polymorphisms were reported to confer susceptibility to disease and disease protection or reduced risk (Table 3).…”

Section: Role Of P450s In Chemotherapymentioning

confidence: 99%

The Multifarious Link between Cytochrome P450s and Cancer

Alzahrani

2020

Oxidative Medicine and Cellular Longevity

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Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an important role in the metabolism of endogenous as well as exogenous substances, especially drugs. Moreover, many P450s can serve as targets for disease therapy. Increasing reports of epidemiological, diagnostic, and clinical research indicate that P450s are enzymes that play a major part in the formation of cancer, prevention, and metastasis. The purposes of this review are to shed light on the current state of knowledge about the cancer molecular mechanism involving P450s and to summarize the link between the cancer effects and the participation of P450s.

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Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan

Cited by 22 publications

References 48 publications

Is there adaptation in the human genome for taste perception and phase I biotransformation?

Is there adaptation in the human genome for taste perception and phase I biotransformation?

Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia

The Multifarious Link between Cytochrome P450s and Cancer

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