Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skin

Gomez, Luis G.; DiMaio, S.; Silva, E G; Mackay, Bruce

doi:10.1097/00000478-198303000-00007

Cited by 129 publications

(58 citation statements)

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“…4 Small cell carcinomas in general are now believed to originate from totipotential stem cells that can differentiate into various cell types that are native to the tissues, eg, TTF-1-positive stem cell for pulmonary small cell carcinoma. 3 This hypothesis may explain occasional cases of small cell carcinoma with other components such as squamous cell carcinoma 17 and adenocarcinoma, 18 the findings described in a variety of organs including skin and lung. [17][18][19][20] Cutaneous metastasis of visceral carcinomas is usually an expression of the disseminated disease.…”

Section: Discussionmentioning

confidence: 92%

“…3 This hypothesis may explain occasional cases of small cell carcinoma with other components such as squamous cell carcinoma 17 and adenocarcinoma, 18 the findings described in a variety of organs including skin and lung. [17][18][19][20] Cutaneous metastasis of visceral carcinomas is usually an expression of the disseminated disease. 21,22 A skin metastasis, however, may be the presenting feature, and this phenomenon has been described most frequently in carcinomas of the lung, notably small cell carcinoma.…”

Section: Discussionmentioning

confidence: 92%

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MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma

2008

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Merkel cell carcinoma is the cutaneous counterpart of small cell carcinoma, and the most important differential diagnosis is cutaneous metastasis of small cell carcinoma of the lung. There have been a handful of studies reporting on the utility of a variety of immunohistochemical markers that distinguish between the two entities. Achaete-scute complex-like 1 (MASH1, ASCL1) is important in the development of the brain and the diffuse neuroendocrine system including pulmonary neuroendocrine cells. A recent study, using a cDNA array, identified Mash1 as one of the best classifier genes to differentiate pulmonary small cell carcinoma from Merkel cell carcinoma. We immunohistochemically applied this finding to the diagnostic setting. A total of 30 cases of Merkel cell carcinoma and 59 cases of small cell carcinoma of the lung were immunostained with anti-MASH1 and TTF-1 antibodies. Of 59 small cell carcinomas, 49 (83%) expressed MASH1 in nuclear staining whereas out of 59 small cell carcinomas, 43 (73%) expressed TTF-1 in nuclear staining. MASH1 was completely negative in all 30 Merkel cell carcinomas whereas TTF-1 expression was seen in 1 of the 30 Merkel cell carcinomas (3%). MASH1 is a useful adjunct marker for differentiating small cell carcinoma of the lung from Merkel cell carcinoma.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma

2008

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“…25 Still others explain the frequent association of MCC and squamous cell carcinoma as secondary to a common carcinogen effect on different progenitor cells. 2,14 The latter hypothesis, however, does not explain the existence of transitional cells.…”

Section: Discussionmentioning

confidence: 99%

“…10 MCC admixed with or adjacent to 1 squamous cell carcinoma (SCC) is a well-documented phenomenon, one that some believe is a testament to the epithelial stem cell origin of MCC. 2,3,8,[11][12][13][14][15][16][17] There is one recent report of MCC found in association with an actinic keratosis that, in successive local recurrences after radiotherapy, evolved into an atypical fibroxanthoma-like SCC. 18 Immunohistochemical features of the lesion were distinct from an atypical fibroxanthoma (data not presented).…”

Section: Sommairementioning

confidence: 99%

Combined Merkel Cell Carcinoma and Atypical Fibroxanthoma

Youker

Billingsley

2005

J Cutan Med Surg

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“…Our second case had typical chronic arsenicism with presentations of arsenic keratosis, multiple Bowen's disease, BCC, and SCC. The coexistence of MCC and SCC has been reported in the literature, but the relationship between these tumors has not been extensively elucidated 19,20) . MCC occurring in our patients, who had chronic arsenicism, indicates that arsenic is a carcinogen that may lead to MCC in addition to SCC, BCC, and Bowen's disease, by acting on different progenitor cells.…”

Section: Discussionmentioning

confidence: 99%

Merkel Cell Carcinoma in Patients with Long‐Term Ingestion of Arsenic

Tsai

Lee

et al. 2005

Journal of Occupational Health

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Merkel Cell Carcinoma in Patients withLong-Term Ingestion of Arsenic: Sheng-Yow HO, et al. Departments of Radiation Oncology, Sin-Lau Christian Hospital, Taiwan-Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin, mostly occurring late in life on sun-exposed body parts. Little is known about the specific etiological factors in the pathogenesis of MCC. A previous report indicated that arsenic exposure might cause MCC, which might be another specific type of skin cancer associated with arsenic exposure. On the southwest coast of Taiwan, high arsenic levels in artesian well water have been documented, and various diseases associated with arsenic exposure have been found to be prevalent in this area. We report two pathologically confirmed cases of MCC in patients who had histories of long-term ingestion of arsenic from drinking water. The tumors were on the anterior chest wall, an area less exposed to the sun, in both cases. The literature on the dose-response relationship between arsenic exposure and MCC is limited. We estimated that the total arsenic ingested by these two cases was around 14.7 and 2.6 gm, respectively. We also tried to assess the cancer risk on the basis of the estimated doses of arsenic exposure and the cancer risk model developed by the U.S. Environmental Protection Agency (EPA). The estimated lifetime target cancer risk was 1.3 × 10 -2 in Case 1 and 2.3 × 10 -3 in Case 2. Both are much higher than the 10 -6 upper limit on lifetime cancer risk put forth by the U.S. EPA health protection standard. We believe that arsenic intoxication played an important role in the carcinogenic process of MCC in our cases. (J Occup Health 2005; 47: 188-192) Field Study

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Association between neuroendocrine (Merkel cell) carcinoma and squamous carcinoma of the skin

Cited by 129 publications

References 0 publications

MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma

MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma

Combined Merkel Cell Carcinoma and Atypical Fibroxanthoma

Merkel Cell Carcinoma in Patients with Long‐Term Ingestion of Arsenic

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